New insights in the mode of action of (+)-erythravine and (+)-11α-hydroxy-erythravine alkaloids

Erythrinian alkaloids ((+)-erythravine and (+)-11-α-hydroxy-erythravine) have been pointed as the main responsible agents for the anticonvulsant and anxiolytic properties of Erythrina mulungu Mart ex Benth. The present work provides a new set of information about the mode of action of these alkaloid...

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Veröffentlicht in:	European journal of pharmacology 2020-10, Vol.885, p.173390, Article 173390
Hauptverfasser:	Gelfuso, Erica A., Reis, Suelen L., Aguiar, Daiane S.R., Faggion, Silmara A., Gomes, Flávia M.M., Galan, Diogo T., Peigneur, Steve, Pereira, Ana M.S., Mortari, Márcia R., Cunha, Alexandra O.S., Tytgat, Jan, Beleboni, Renê O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - pharmacology Anticonvulsants - pharmacology Cerebral Cortex - drug effects Cerebral Cortex - metabolism E. mulungu Electrophysiology Erythrina - chemistry Erythrinian alkaloids GABA gamma-Aminobutyric Acid - metabolism Glutamate Glutamic Acid - metabolism Heterocyclic Compounds, 4 or More Rings - pharmacology Ion channels Life Sciences Neurobiology Neurons and Cognition Nicotinic Antagonists - pharmacology Oocytes Patch-Clamp Techniques Pharmaceutical sciences Pharmacology Potassium - metabolism Receptors, Nicotinic - drug effects Sodium Channels - metabolism Synaptosomes - drug effects Synaptosomes - metabolism Xenopus laevis
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