Portraying infective endocarditis: results of multinational ID-IRI study
Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between Ja...
Gespeichert in:
| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2019-09, Vol.38 (9), p.1753-1763 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1763 |
|---|---|
| container_issue | 9 |
| container_start_page | 1753 |
| container_title | European journal of clinical microbiology & infectious diseases |
| container_volume | 38 |
| creator | Erdem, Hakan Puca, Edmond Ruch, Yvon Santos, Lurdes Ghanem-Zoubi, Nesrin Argemi, Xavier Hansmann, Yves Guner, Rahmet Tonziello, Gilda Mazzucotelli, Jean-Philippe Como, Najada Kose, Sukran Batirel, Ayse Inan, Asuman Tulek, Necla Pekok, Abdullah Umut Khan, Ejaz Ahmed Iyisoy, Atilla Meric-Koc, Meliha Kaya-Kalem, Ayse Martins, Pedro Palma Hasanoglu, Imran Silva-Pinto, André Oztoprak, Nefise Duro, Raquel Almajid, Fahad Dogan, Mustafa Dauby, Nicolas Gunst, Jesper Damsgaard Tekin, Recep Konopnicki, Deborah Petrosillo, Nicola Bozkurt, Ilkay Wadi, Jamal Popescu, Corneliu Balkan, Ilker Inanc Ozer-Balin, Safak Zupanc, Tatjana Lejko Cascio, Antonio Dumitru, Irina Magdalena Erdem, Aysegul Ersoz, Gulden Tasbakan, Meltem Ajamieh, Oday Abu Sirmatel, Fatma Florescu, Simin Gulsun, Serda Ozkaya, Hacer Deniz Sari, Sema Tosun, Selma Avci, Meltem Cag, Yasemin Celebi, Guven Sagmak-Tartar, Ayse Karakus, Sumeyra Sener, Alper Dedej, Arjeta Oncu, Serkan Del Vecchio, Rosa Fontana Ozturk-Engin, Derya Agalar, Canan |
| description | Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (
n
= 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (
Staphylococcus aureus
(
n
= 267, 33.6%),
Streptococcus viridans
(
n
= 149, 18.7%), enterococci (
n
= 128, 16.1%), coagulase-negative staphylococci (
n
= 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (
n
= 394, 45.4%) and mitral valves (
n
= 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (
n
= 101, 16%), PVE (
n
= 49, 22.9%),
p
= 0.042). |
| doi_str_mv | 10.1007/s10096-019-03607-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02921185v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2275257222</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-2da88a7930ac035f39387a11fbbd6562cdc83ee0ce3f40203b5e77113484a97e3</originalsourceid><addsrcrecordid>eNp9kUFPGzEQha0KVAL0D_SAVuJSDi5jz25s94YoNJEiUSE4W47XG4w2a2rvIvLv63RpkDhwGY_s773x6BHylcF3BiDOU65qSoEpCjgFQV8-kQkrsaIlCtwjE1BYUiU4HpDDlB4hi6QQn8kBMiYFgpiQ2e8Q-2g2vlsVvmuc7f2zK1xXB2ti7XuffhTRpaHtUxGaYp0b35neh860xfwnnd_Oi9QP9eaY7DemTe7L63lE7q-v7i5ndHHza355saC2BNVTXhspjVAIxgJWDSqUwjDWLJf1tJpyW1uJzoF12JTAAZeVE4IxLGVplHB4RM5G3wfT6qfo1yZudDBezy4WensHXPG8XvXMMvttZJ9i-DO41Ou1T9a1relcGJLmXFS8EpzzjJ6-Qx_DEPOSWwplpiTKTPGRsjGkFF2z-wEDvc1Ej5nonIn-l4l-yaKTV-thuXb1TvI_hAzgCKT81K1cfJv9ge1fgPeVmw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2238257838</pqid></control><display><type>article</type><title>Portraying infective endocarditis: results of multinational ID-IRI study</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Erdem, Hakan ; Puca, Edmond ; Ruch, Yvon ; Santos, Lurdes ; Ghanem-Zoubi, Nesrin ; Argemi, Xavier ; Hansmann, Yves ; Guner, Rahmet ; Tonziello, Gilda ; Mazzucotelli, Jean-Philippe ; Como, Najada ; Kose, Sukran ; Batirel, Ayse ; Inan, Asuman ; Tulek, Necla ; Pekok, Abdullah Umut ; Khan, Ejaz Ahmed ; Iyisoy, Atilla ; Meric-Koc, Meliha ; Kaya-Kalem, Ayse ; Martins, Pedro Palma ; Hasanoglu, Imran ; Silva-Pinto, André ; Oztoprak, Nefise ; Duro, Raquel ; Almajid, Fahad ; Dogan, Mustafa ; Dauby, Nicolas ; Gunst, Jesper Damsgaard ; Tekin, Recep ; Konopnicki, Deborah ; Petrosillo, Nicola ; Bozkurt, Ilkay ; Wadi, Jamal ; Popescu, Corneliu ; Balkan, Ilker Inanc ; Ozer-Balin, Safak ; Zupanc, Tatjana Lejko ; Cascio, Antonio ; Dumitru, Irina Magdalena ; Erdem, Aysegul ; Ersoz, Gulden ; Tasbakan, Meltem ; Ajamieh, Oday Abu ; Sirmatel, Fatma ; Florescu, Simin ; Gulsun, Serda ; Ozkaya, Hacer Deniz ; Sari, Sema ; Tosun, Selma ; Avci, Meltem ; Cag, Yasemin ; Celebi, Guven ; Sagmak-Tartar, Ayse ; Karakus, Sumeyra ; Sener, Alper ; Dedej, Arjeta ; Oncu, Serkan ; Del Vecchio, Rosa Fontana ; Ozturk-Engin, Derya ; Agalar, Canan</creator><creatorcontrib>Erdem, Hakan ; Puca, Edmond ; Ruch, Yvon ; Santos, Lurdes ; Ghanem-Zoubi, Nesrin ; Argemi, Xavier ; Hansmann, Yves ; Guner, Rahmet ; Tonziello, Gilda ; Mazzucotelli, Jean-Philippe ; Como, Najada ; Kose, Sukran ; Batirel, Ayse ; Inan, Asuman ; Tulek, Necla ; Pekok, Abdullah Umut ; Khan, Ejaz Ahmed ; Iyisoy, Atilla ; Meric-Koc, Meliha ; Kaya-Kalem, Ayse ; Martins, Pedro Palma ; Hasanoglu, Imran ; Silva-Pinto, André ; Oztoprak, Nefise ; Duro, Raquel ; Almajid, Fahad ; Dogan, Mustafa ; Dauby, Nicolas ; Gunst, Jesper Damsgaard ; Tekin, Recep ; Konopnicki, Deborah ; Petrosillo, Nicola ; Bozkurt, Ilkay ; Wadi, Jamal ; Popescu, Corneliu ; Balkan, Ilker Inanc ; Ozer-Balin, Safak ; Zupanc, Tatjana Lejko ; Cascio, Antonio ; Dumitru, Irina Magdalena ; Erdem, Aysegul ; Ersoz, Gulden ; Tasbakan, Meltem ; Ajamieh, Oday Abu ; Sirmatel, Fatma ; Florescu, Simin ; Gulsun, Serda ; Ozkaya, Hacer Deniz ; Sari, Sema ; Tosun, Selma ; Avci, Meltem ; Cag, Yasemin ; Celebi, Guven ; Sagmak-Tartar, Ayse ; Karakus, Sumeyra ; Sener, Alper ; Dedej, Arjeta ; Oncu, Serkan ; Del Vecchio, Rosa Fontana ; Ozturk-Engin, Derya ; Agalar, Canan</creatorcontrib><description>Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (
n
= 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (
Staphylococcus aureus
(
n
= 267, 33.6%),
Streptococcus viridans
(
n
= 149, 18.7%), enterococci (
n
= 128, 16.1%), coagulase-negative staphylococci (
n
= 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (
n
= 394, 45.4%) and mitral valves (
n
= 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (
n
= 101, 16%), PVE (
n
= 49, 22.9%),
p
= 0.042).</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-019-03607-x</identifier><identifier>PMID: 31187307</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abscesses ; Adolescent ; Adult ; Age ; Aged ; Aged, 80 and over ; Aorta ; Aortic Valve - microbiology ; Bacteria - isolation & purification ; Biomedical and Life Sciences ; Biomedicine ; Blood ; Brain ; Catheters ; Coagulase ; Endocarditis ; Endocarditis - epidemiology ; Endocarditis - microbiology ; Endocarditis - mortality ; Endocarditis, Bacterial ; Female ; Geriatrics ; Hospital Mortality ; Humans ; Illnesses ; Internal Medicine ; Internationality ; Life Sciences ; Male ; Medical instruments ; Medical Microbiology ; Microbiology and Parasitology ; Middle Aged ; Mitral Valve - microbiology ; Older people ; Original Article ; Pathogens ; Patients ; Prostheses ; Prosthesis-Related Infections - epidemiology ; Prosthesis-Related Infections - microbiology ; Staphylococcal Infections ; Viridans Streptococci ; Young Adult</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2019-09, Vol.38 (9), p.1753-1763</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>European Journal of Clinical Microbiology & Infectious Diseases is a copyright of Springer, (2019). All Rights Reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-2da88a7930ac035f39387a11fbbd6562cdc83ee0ce3f40203b5e77113484a97e3</citedby><cites>FETCH-LOGICAL-c409t-2da88a7930ac035f39387a11fbbd6562cdc83ee0ce3f40203b5e77113484a97e3</cites><orcidid>0000-0002-6265-5227 ; 0000-0002-7697-6849</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-019-03607-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-019-03607-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31187307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02921185$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Erdem, Hakan</creatorcontrib><creatorcontrib>Puca, Edmond</creatorcontrib><creatorcontrib>Ruch, Yvon</creatorcontrib><creatorcontrib>Santos, Lurdes</creatorcontrib><creatorcontrib>Ghanem-Zoubi, Nesrin</creatorcontrib><creatorcontrib>Argemi, Xavier</creatorcontrib><creatorcontrib>Hansmann, Yves</creatorcontrib><creatorcontrib>Guner, Rahmet</creatorcontrib><creatorcontrib>Tonziello, Gilda</creatorcontrib><creatorcontrib>Mazzucotelli, Jean-Philippe</creatorcontrib><creatorcontrib>Como, Najada</creatorcontrib><creatorcontrib>Kose, Sukran</creatorcontrib><creatorcontrib>Batirel, Ayse</creatorcontrib><creatorcontrib>Inan, Asuman</creatorcontrib><creatorcontrib>Tulek, Necla</creatorcontrib><creatorcontrib>Pekok, Abdullah Umut</creatorcontrib><creatorcontrib>Khan, Ejaz Ahmed</creatorcontrib><creatorcontrib>Iyisoy, Atilla</creatorcontrib><creatorcontrib>Meric-Koc, Meliha</creatorcontrib><creatorcontrib>Kaya-Kalem, Ayse</creatorcontrib><creatorcontrib>Martins, Pedro Palma</creatorcontrib><creatorcontrib>Hasanoglu, Imran</creatorcontrib><creatorcontrib>Silva-Pinto, André</creatorcontrib><creatorcontrib>Oztoprak, Nefise</creatorcontrib><creatorcontrib>Duro, Raquel</creatorcontrib><creatorcontrib>Almajid, Fahad</creatorcontrib><creatorcontrib>Dogan, Mustafa</creatorcontrib><creatorcontrib>Dauby, Nicolas</creatorcontrib><creatorcontrib>Gunst, Jesper Damsgaard</creatorcontrib><creatorcontrib>Tekin, Recep</creatorcontrib><creatorcontrib>Konopnicki, Deborah</creatorcontrib><creatorcontrib>Petrosillo, Nicola</creatorcontrib><creatorcontrib>Bozkurt, Ilkay</creatorcontrib><creatorcontrib>Wadi, Jamal</creatorcontrib><creatorcontrib>Popescu, Corneliu</creatorcontrib><creatorcontrib>Balkan, Ilker Inanc</creatorcontrib><creatorcontrib>Ozer-Balin, Safak</creatorcontrib><creatorcontrib>Zupanc, Tatjana Lejko</creatorcontrib><creatorcontrib>Cascio, Antonio</creatorcontrib><creatorcontrib>Dumitru, Irina Magdalena</creatorcontrib><creatorcontrib>Erdem, Aysegul</creatorcontrib><creatorcontrib>Ersoz, Gulden</creatorcontrib><creatorcontrib>Tasbakan, Meltem</creatorcontrib><creatorcontrib>Ajamieh, Oday Abu</creatorcontrib><creatorcontrib>Sirmatel, Fatma</creatorcontrib><creatorcontrib>Florescu, Simin</creatorcontrib><creatorcontrib>Gulsun, Serda</creatorcontrib><creatorcontrib>Ozkaya, Hacer Deniz</creatorcontrib><creatorcontrib>Sari, Sema</creatorcontrib><creatorcontrib>Tosun, Selma</creatorcontrib><creatorcontrib>Avci, Meltem</creatorcontrib><creatorcontrib>Cag, Yasemin</creatorcontrib><creatorcontrib>Celebi, Guven</creatorcontrib><creatorcontrib>Sagmak-Tartar, Ayse</creatorcontrib><creatorcontrib>Karakus, Sumeyra</creatorcontrib><creatorcontrib>Sener, Alper</creatorcontrib><creatorcontrib>Dedej, Arjeta</creatorcontrib><creatorcontrib>Oncu, Serkan</creatorcontrib><creatorcontrib>Del Vecchio, Rosa Fontana</creatorcontrib><creatorcontrib>Ozturk-Engin, Derya</creatorcontrib><creatorcontrib>Agalar, Canan</creatorcontrib><title>Portraying infective endocarditis: results of multinational ID-IRI study</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (
n
= 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (
Staphylococcus aureus
(
n
= 267, 33.6%),
Streptococcus viridans
(
n
= 149, 18.7%), enterococci (
n
= 128, 16.1%), coagulase-negative staphylococci (
n
= 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (
n
= 394, 45.4%) and mitral valves (
n
= 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (
n
= 101, 16%), PVE (
n
= 49, 22.9%),
p
= 0.042).</description><subject>Abscesses</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aorta</subject><subject>Aortic Valve - microbiology</subject><subject>Bacteria - isolation & purification</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood</subject><subject>Brain</subject><subject>Catheters</subject><subject>Coagulase</subject><subject>Endocarditis</subject><subject>Endocarditis - epidemiology</subject><subject>Endocarditis - microbiology</subject><subject>Endocarditis - mortality</subject><subject>Endocarditis, Bacterial</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Internal Medicine</subject><subject>Internationality</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical instruments</subject><subject>Medical Microbiology</subject><subject>Microbiology and Parasitology</subject><subject>Middle Aged</subject><subject>Mitral Valve - microbiology</subject><subject>Older people</subject><subject>Original Article</subject><subject>Pathogens</subject><subject>Patients</subject><subject>Prostheses</subject><subject>Prosthesis-Related Infections - epidemiology</subject><subject>Prosthesis-Related Infections - microbiology</subject><subject>Staphylococcal Infections</subject><subject>Viridans Streptococci</subject><subject>Young Adult</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUFPGzEQha0KVAL0D_SAVuJSDi5jz25s94YoNJEiUSE4W47XG4w2a2rvIvLv63RpkDhwGY_s773x6BHylcF3BiDOU65qSoEpCjgFQV8-kQkrsaIlCtwjE1BYUiU4HpDDlB4hi6QQn8kBMiYFgpiQ2e8Q-2g2vlsVvmuc7f2zK1xXB2ti7XuffhTRpaHtUxGaYp0b35neh860xfwnnd_Oi9QP9eaY7DemTe7L63lE7q-v7i5ndHHza355saC2BNVTXhspjVAIxgJWDSqUwjDWLJf1tJpyW1uJzoF12JTAAZeVE4IxLGVplHB4RM5G3wfT6qfo1yZudDBezy4WensHXPG8XvXMMvttZJ9i-DO41Ou1T9a1relcGJLmXFS8EpzzjJ6-Qx_DEPOSWwplpiTKTPGRsjGkFF2z-wEDvc1Ej5nonIn-l4l-yaKTV-thuXb1TvI_hAzgCKT81K1cfJv9ge1fgPeVmw</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Erdem, Hakan</creator><creator>Puca, Edmond</creator><creator>Ruch, Yvon</creator><creator>Santos, Lurdes</creator><creator>Ghanem-Zoubi, Nesrin</creator><creator>Argemi, Xavier</creator><creator>Hansmann, Yves</creator><creator>Guner, Rahmet</creator><creator>Tonziello, Gilda</creator><creator>Mazzucotelli, Jean-Philippe</creator><creator>Como, Najada</creator><creator>Kose, Sukran</creator><creator>Batirel, Ayse</creator><creator>Inan, Asuman</creator><creator>Tulek, Necla</creator><creator>Pekok, Abdullah Umut</creator><creator>Khan, Ejaz Ahmed</creator><creator>Iyisoy, Atilla</creator><creator>Meric-Koc, Meliha</creator><creator>Kaya-Kalem, Ayse</creator><creator>Martins, Pedro Palma</creator><creator>Hasanoglu, Imran</creator><creator>Silva-Pinto, André</creator><creator>Oztoprak, Nefise</creator><creator>Duro, Raquel</creator><creator>Almajid, Fahad</creator><creator>Dogan, Mustafa</creator><creator>Dauby, Nicolas</creator><creator>Gunst, Jesper Damsgaard</creator><creator>Tekin, Recep</creator><creator>Konopnicki, Deborah</creator><creator>Petrosillo, Nicola</creator><creator>Bozkurt, Ilkay</creator><creator>Wadi, Jamal</creator><creator>Popescu, Corneliu</creator><creator>Balkan, Ilker Inanc</creator><creator>Ozer-Balin, Safak</creator><creator>Zupanc, Tatjana Lejko</creator><creator>Cascio, Antonio</creator><creator>Dumitru, Irina Magdalena</creator><creator>Erdem, Aysegul</creator><creator>Ersoz, Gulden</creator><creator>Tasbakan, Meltem</creator><creator>Ajamieh, Oday Abu</creator><creator>Sirmatel, Fatma</creator><creator>Florescu, Simin</creator><creator>Gulsun, Serda</creator><creator>Ozkaya, Hacer Deniz</creator><creator>Sari, Sema</creator><creator>Tosun, Selma</creator><creator>Avci, Meltem</creator><creator>Cag, Yasemin</creator><creator>Celebi, Guven</creator><creator>Sagmak-Tartar, Ayse</creator><creator>Karakus, Sumeyra</creator><creator>Sener, Alper</creator><creator>Dedej, Arjeta</creator><creator>Oncu, Serkan</creator><creator>Del Vecchio, Rosa Fontana</creator><creator>Ozturk-Engin, Derya</creator><creator>Agalar, Canan</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-6265-5227</orcidid><orcidid>https://orcid.org/0000-0002-7697-6849</orcidid></search><sort><creationdate>20190901</creationdate><title>Portraying infective endocarditis: results of multinational ID-IRI study</title><author>Erdem, Hakan ; Puca, Edmond ; Ruch, Yvon ; Santos, Lurdes ; Ghanem-Zoubi, Nesrin ; Argemi, Xavier ; Hansmann, Yves ; Guner, Rahmet ; Tonziello, Gilda ; Mazzucotelli, Jean-Philippe ; Como, Najada ; Kose, Sukran ; Batirel, Ayse ; Inan, Asuman ; Tulek, Necla ; Pekok, Abdullah Umut ; Khan, Ejaz Ahmed ; Iyisoy, Atilla ; Meric-Koc, Meliha ; Kaya-Kalem, Ayse ; Martins, Pedro Palma ; Hasanoglu, Imran ; Silva-Pinto, André ; Oztoprak, Nefise ; Duro, Raquel ; Almajid, Fahad ; Dogan, Mustafa ; Dauby, Nicolas ; Gunst, Jesper Damsgaard ; Tekin, Recep ; Konopnicki, Deborah ; Petrosillo, Nicola ; Bozkurt, Ilkay ; Wadi, Jamal ; Popescu, Corneliu ; Balkan, Ilker Inanc ; Ozer-Balin, Safak ; Zupanc, Tatjana Lejko ; Cascio, Antonio ; Dumitru, Irina Magdalena ; Erdem, Aysegul ; Ersoz, Gulden ; Tasbakan, Meltem ; Ajamieh, Oday Abu ; Sirmatel, Fatma ; Florescu, Simin ; Gulsun, Serda ; Ozkaya, Hacer Deniz ; Sari, Sema ; Tosun, Selma ; Avci, Meltem ; Cag, Yasemin ; Celebi, Guven ; Sagmak-Tartar, Ayse ; Karakus, Sumeyra ; Sener, Alper ; Dedej, Arjeta ; Oncu, Serkan ; Del Vecchio, Rosa Fontana ; Ozturk-Engin, Derya ; Agalar, Canan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-2da88a7930ac035f39387a11fbbd6562cdc83ee0ce3f40203b5e77113484a97e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abscesses</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aorta</topic><topic>Aortic Valve - microbiology</topic><topic>Bacteria - isolation & purification</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood</topic><topic>Brain</topic><topic>Catheters</topic><topic>Coagulase</topic><topic>Endocarditis</topic><topic>Endocarditis - epidemiology</topic><topic>Endocarditis - microbiology</topic><topic>Endocarditis - mortality</topic><topic>Endocarditis, Bacterial</topic><topic>Female</topic><topic>Geriatrics</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Illnesses</topic><topic>Internal Medicine</topic><topic>Internationality</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medical instruments</topic><topic>Medical Microbiology</topic><topic>Microbiology and Parasitology</topic><topic>Middle Aged</topic><topic>Mitral Valve - microbiology</topic><topic>Older people</topic><topic>Original Article</topic><topic>Pathogens</topic><topic>Patients</topic><topic>Prostheses</topic><topic>Prosthesis-Related Infections - epidemiology</topic><topic>Prosthesis-Related Infections - microbiology</topic><topic>Staphylococcal Infections</topic><topic>Viridans Streptococci</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erdem, Hakan</creatorcontrib><creatorcontrib>Puca, Edmond</creatorcontrib><creatorcontrib>Ruch, Yvon</creatorcontrib><creatorcontrib>Santos, Lurdes</creatorcontrib><creatorcontrib>Ghanem-Zoubi, Nesrin</creatorcontrib><creatorcontrib>Argemi, Xavier</creatorcontrib><creatorcontrib>Hansmann, Yves</creatorcontrib><creatorcontrib>Guner, Rahmet</creatorcontrib><creatorcontrib>Tonziello, Gilda</creatorcontrib><creatorcontrib>Mazzucotelli, Jean-Philippe</creatorcontrib><creatorcontrib>Como, Najada</creatorcontrib><creatorcontrib>Kose, Sukran</creatorcontrib><creatorcontrib>Batirel, Ayse</creatorcontrib><creatorcontrib>Inan, Asuman</creatorcontrib><creatorcontrib>Tulek, Necla</creatorcontrib><creatorcontrib>Pekok, Abdullah Umut</creatorcontrib><creatorcontrib>Khan, Ejaz Ahmed</creatorcontrib><creatorcontrib>Iyisoy, Atilla</creatorcontrib><creatorcontrib>Meric-Koc, Meliha</creatorcontrib><creatorcontrib>Kaya-Kalem, Ayse</creatorcontrib><creatorcontrib>Martins, Pedro Palma</creatorcontrib><creatorcontrib>Hasanoglu, Imran</creatorcontrib><creatorcontrib>Silva-Pinto, André</creatorcontrib><creatorcontrib>Oztoprak, Nefise</creatorcontrib><creatorcontrib>Duro, Raquel</creatorcontrib><creatorcontrib>Almajid, Fahad</creatorcontrib><creatorcontrib>Dogan, Mustafa</creatorcontrib><creatorcontrib>Dauby, Nicolas</creatorcontrib><creatorcontrib>Gunst, Jesper Damsgaard</creatorcontrib><creatorcontrib>Tekin, Recep</creatorcontrib><creatorcontrib>Konopnicki, Deborah</creatorcontrib><creatorcontrib>Petrosillo, Nicola</creatorcontrib><creatorcontrib>Bozkurt, Ilkay</creatorcontrib><creatorcontrib>Wadi, Jamal</creatorcontrib><creatorcontrib>Popescu, Corneliu</creatorcontrib><creatorcontrib>Balkan, Ilker Inanc</creatorcontrib><creatorcontrib>Ozer-Balin, Safak</creatorcontrib><creatorcontrib>Zupanc, Tatjana Lejko</creatorcontrib><creatorcontrib>Cascio, Antonio</creatorcontrib><creatorcontrib>Dumitru, Irina Magdalena</creatorcontrib><creatorcontrib>Erdem, Aysegul</creatorcontrib><creatorcontrib>Ersoz, Gulden</creatorcontrib><creatorcontrib>Tasbakan, Meltem</creatorcontrib><creatorcontrib>Ajamieh, Oday Abu</creatorcontrib><creatorcontrib>Sirmatel, Fatma</creatorcontrib><creatorcontrib>Florescu, Simin</creatorcontrib><creatorcontrib>Gulsun, Serda</creatorcontrib><creatorcontrib>Ozkaya, Hacer Deniz</creatorcontrib><creatorcontrib>Sari, Sema</creatorcontrib><creatorcontrib>Tosun, Selma</creatorcontrib><creatorcontrib>Avci, Meltem</creatorcontrib><creatorcontrib>Cag, Yasemin</creatorcontrib><creatorcontrib>Celebi, Guven</creatorcontrib><creatorcontrib>Sagmak-Tartar, Ayse</creatorcontrib><creatorcontrib>Karakus, Sumeyra</creatorcontrib><creatorcontrib>Sener, Alper</creatorcontrib><creatorcontrib>Dedej, Arjeta</creatorcontrib><creatorcontrib>Oncu, Serkan</creatorcontrib><creatorcontrib>Del Vecchio, Rosa Fontana</creatorcontrib><creatorcontrib>Ozturk-Engin, Derya</creatorcontrib><creatorcontrib>Agalar, Canan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>European journal of clinical microbiology & infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erdem, Hakan</au><au>Puca, Edmond</au><au>Ruch, Yvon</au><au>Santos, Lurdes</au><au>Ghanem-Zoubi, Nesrin</au><au>Argemi, Xavier</au><au>Hansmann, Yves</au><au>Guner, Rahmet</au><au>Tonziello, Gilda</au><au>Mazzucotelli, Jean-Philippe</au><au>Como, Najada</au><au>Kose, Sukran</au><au>Batirel, Ayse</au><au>Inan, Asuman</au><au>Tulek, Necla</au><au>Pekok, Abdullah Umut</au><au>Khan, Ejaz Ahmed</au><au>Iyisoy, Atilla</au><au>Meric-Koc, Meliha</au><au>Kaya-Kalem, Ayse</au><au>Martins, Pedro Palma</au><au>Hasanoglu, Imran</au><au>Silva-Pinto, André</au><au>Oztoprak, Nefise</au><au>Duro, Raquel</au><au>Almajid, Fahad</au><au>Dogan, Mustafa</au><au>Dauby, Nicolas</au><au>Gunst, Jesper Damsgaard</au><au>Tekin, Recep</au><au>Konopnicki, Deborah</au><au>Petrosillo, Nicola</au><au>Bozkurt, Ilkay</au><au>Wadi, Jamal</au><au>Popescu, Corneliu</au><au>Balkan, Ilker Inanc</au><au>Ozer-Balin, Safak</au><au>Zupanc, Tatjana Lejko</au><au>Cascio, Antonio</au><au>Dumitru, Irina Magdalena</au><au>Erdem, Aysegul</au><au>Ersoz, Gulden</au><au>Tasbakan, Meltem</au><au>Ajamieh, Oday Abu</au><au>Sirmatel, Fatma</au><au>Florescu, Simin</au><au>Gulsun, Serda</au><au>Ozkaya, Hacer Deniz</au><au>Sari, Sema</au><au>Tosun, Selma</au><au>Avci, Meltem</au><au>Cag, Yasemin</au><au>Celebi, Guven</au><au>Sagmak-Tartar, Ayse</au><au>Karakus, Sumeyra</au><au>Sener, Alper</au><au>Dedej, Arjeta</au><au>Oncu, Serkan</au><au>Del Vecchio, Rosa Fontana</au><au>Ozturk-Engin, Derya</au><au>Agalar, Canan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Portraying infective endocarditis: results of multinational ID-IRI study</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>38</volume><issue>9</issue><spage>1753</spage><epage>1763</epage><pages>1753-1763</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (
n
= 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (
Staphylococcus aureus
(
n
= 267, 33.6%),
Streptococcus viridans
(
n
= 149, 18.7%), enterococci (
n
= 128, 16.1%), coagulase-negative staphylococci (
n
= 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (
n
= 394, 45.4%) and mitral valves (
n
= 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (
n
= 101, 16%), PVE (
n
= 49, 22.9%),
p
= 0.042).</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31187307</pmid><doi>10.1007/s10096-019-03607-x</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6265-5227</orcidid><orcidid>https://orcid.org/0000-0002-7697-6849</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-9723 |
| ispartof | European journal of clinical microbiology & infectious diseases, 2019-09, Vol.38 (9), p.1753-1763 |
| issn | 0934-9723 1435-4373 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02921185v1 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Abscesses Adolescent Adult Age Aged Aged, 80 and over Aorta Aortic Valve - microbiology Bacteria - isolation & purification Biomedical and Life Sciences Biomedicine Blood Brain Catheters Coagulase Endocarditis Endocarditis - epidemiology Endocarditis - microbiology Endocarditis - mortality Endocarditis, Bacterial Female Geriatrics Hospital Mortality Humans Illnesses Internal Medicine Internationality Life Sciences Male Medical instruments Medical Microbiology Microbiology and Parasitology Middle Aged Mitral Valve - microbiology Older people Original Article Pathogens Patients Prostheses Prosthesis-Related Infections - epidemiology Prosthesis-Related Infections - microbiology Staphylococcal Infections Viridans Streptococci Young Adult |
| title | Portraying infective endocarditis: results of multinational ID-IRI study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T05%3A49%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Portraying%20infective%20endocarditis:%20results%20of%20multinational%20ID-IRI%20study&rft.jtitle=European%20journal%20of%20clinical%20microbiology%20&%20infectious%20diseases&rft.au=Erdem,%20Hakan&rft.date=2019-09-01&rft.volume=38&rft.issue=9&rft.spage=1753&rft.epage=1763&rft.pages=1753-1763&rft.issn=0934-9723&rft.eissn=1435-4373&rft_id=info:doi/10.1007/s10096-019-03607-x&rft_dat=%3Cproquest_hal_p%3E2275257222%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2238257838&rft_id=info:pmid/31187307&rfr_iscdi=true |