Absence of impact of direct acting antivirals for hepatitis C virus on recurrent hepatocellular carcinoma tumor growth in the AFEF/ANRS CO22 Hepather cohort
•Our blinded analysis of HCC recurrence following “curative” treatment:•Argues against the “curative” efficacy of the first treatment of HCC in one third of patients.•Evidences that DAA therapy has no significant impact on the severity or progression of HCC recurrence.•Evidences that DAA therapy doe...
Gespeichert in:
| Veröffentlicht in: | Clinics and research in hepatology and gastroenterology 2021-01, Vol.45 (1), p.101459-101459, Article 101459 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 101459 |
|---|---|
| container_issue | 1 |
| container_start_page | 101459 |
| container_title | Clinics and research in hepatology and gastroenterology |
| container_volume | 45 |
| creator | Vallet-Pichard, Anais Dorival, Celine Zoulim, Fabien Bourlière, Marc Calès, Paul Guyader, Dominique Bronowicki, Jean-Pierre Loustaud-Ratti, Veronique Gournay, Jerome de Ledinghen, Victor Ganne, Nathalie Metivier, Sophie Leroy, Vincent Rosa, Isabelle Mathurin, Philippe Cagnot, Carole Bonnet, Delphine Payssan-Sicart, Virginie Pomes, Chloe Bailly, François Giboz, Dominique Hartig-Lavie, Kerstin Maynard, Marianne Billaud, Eric Boutoille, David Cheraud-Carpentier, Marjorie Benhida, Jaouad Lannes, Adrien Lunel, Françoise Giuily, Nathalie Chibah, Aziza Bonardi, Karim Vallet-Pichard, Anaïs Foucher, Juliette Hiriart, Jean-Baptiste Chermak, Faiza Ansaldi, Christelle Amara, Nisserine Ben Chouquet, Laëtitia Anty, Rodolphe Gelsi, Eve Truchi, Régine Luckina, Elena Messaoudi, Nadia Moussali, Joseph De Dieuleveult, Barbara Poter, Pascal Ahmed, Si Nafa Si Grando-Lemaire, Véronique Nahon, Pierre Jezequel, Caroline Brener, Audrey Laligant, Anne Rabot, Aline Mutter, Catherine Simo-Noumbissie, Pauline Razi, Esma Bensenane, Mouni Nani, Abdelbasset Hassani-Nani, Sarah Bernard, Marie-Albertine Pageaux, Georges-Philippe Bismuth, Michael Bureau, Christophe Robic, Marie-Angèle Tarallo, Léa Froissart, Bruno Hilleret, Marie-Noelle Grard, Victorien François, Muriel Ouedraogo, Christian Pauleau, Christelle Varault, Anne Andreani, Tony Angoulevant, Bénédicte Chevance, Azeline Serfaty, Lawrence Coilly, Audrey Vallée, Jean-Charles Duclos Tateo, Mariagrazia Bonny, Corinne Brigitte, Chanteranne Muti, Léon Babouri, Abdenour Filipe, Virginie Babouri, Abdenour Costes, Laurent Hagège, Hervé Merbah, Soraya Carrier, Paul Artu, Florent Dharancy, Sébastien Louvet, Alexandre Mouillot, Thomas Barbereau, Didier Archambeaud, Isabelle Amara, Nisserine Ben Botta-Fridlund, Danièle Saillard, Eric Lafrance, Marie-Josée |
| description | •Our blinded analysis of HCC recurrence following “curative” treatment:•Argues against the “curative” efficacy of the first treatment of HCC in one third of patients.•Evidences that DAA therapy has no significant impact on the severity or progression of HCC recurrence.•Evidences that DAA therapy does not impact overall survival and could be considered in cirrhotic patients with prior history of HCC.
Although it has now been excluded that direct-acting antivirals (DAA) are associated with a significant risk of hepatocellular carcinoma (HCC) in HCV-infected patients, a possible effect of DAA on tumor growth is still a subject of debate. We performed a blind comparison of the kinetics of HCC recurrence in patients after HCV treatment with or without DAA to evaluate the potential aggressiveness of HCC after DAA treatment.
Thirty-nine HCV-infected patients from the AFEF/ANRS CO22 Hepather cohort who experienced HCC recurrence after so-called curative treatment were evaluated. Contrast-enhanced CT and/or MR images were read blindly 6 months before HCC recurrence and during the follow-up period. Seventeen patients who received DAA (DAA+) before HCC recurrence were compared to the 22 who did not receive (DAA−), according to the LiRads and mRECIST criteria.
There were 28 men and 11 women, median age 62 years old, 37 (95%) with cirrhosis. DAA+ patients had a lower median MELD score (8±2 vs. 10±4, P=0.0286) than DAA− patients. The median time to HCC recurrence (time from the date of curative treatment to the diagnosis of recurrence) was not different (20 vs. 18 months) (P=0.73) between the two groups. There was no difference between the 2 groups in the overall survival and/or transplantation-free survival (P=0.71) and for the mRECIST time to progression (P=0.25).
This blinded analysis of HCC recurrence after HCC treatment does not support any negative impact of DAA therapy on the severity or progression of recurrent HCC. |
| doi_str_mv | 10.1016/j.clinre.2020.04.022 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02921184v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2210740120301522</els_id><sourcerecordid>2418730823</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-3167d8cfc03154994f664eca4b74e50527333d2f708430fa6638ba9e248435193</originalsourceid><addsrcrecordid>eNp9kc1q3DAUhU1paUKaNwhFy3YxztWP_zYFM2Q6haGBpIXshEa-jjXY1lSSJ_Rd-rCVcTrLaqN7pe_cg3SS5IZCSoHmt4dU92Z0mDJgkIJIgbE3ySVjFFaFoE9vzzXQi-Ta-wPEJTIoC_o-ueAsqzIK_DL5U-89jhqJbYkZjkqHuWqMw1jFzozPRI3BnIxTvSetdaTDowomGE_WJB5PntiRRH5yDsewXFuNfT_1yhGtnDajHRQJ0xDVz86-hI6YkYQOSb2529zW3x8eyfqeMbKdtR1Gle2sCx-Sd210xevX_Sr5ubn7sd6udvdfv63r3UoLwcKK07xoSt1q4DQTVSXaPBeoldgXAjPIWME5b1hbQCk4tCrPeblXFTIR-4xW_Cr5vMztVC-PzgzK_ZZWGbmtd3I-A1YxSktxopH9tLBHZ39N6IMcjJ9fq0a0k5dM0LLgUDIeUbGg2lnvHbbn2RTkHKM8yCVGOccoQUQjFmUfXx2m_YDNWfQvtAh8WQCMf3Iy6KTXZg5xiU021vzf4S9TXq7x</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2418730823</pqid></control><display><type>article</type><title>Absence of impact of direct acting antivirals for hepatitis C virus on recurrent hepatocellular carcinoma tumor growth in the AFEF/ANRS CO22 Hepather cohort</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Vallet-Pichard, Anais ; Dorival, Celine ; Zoulim, Fabien ; Bourlière, Marc ; Calès, Paul ; Guyader, Dominique ; Bronowicki, Jean-Pierre ; Loustaud-Ratti, Veronique ; Gournay, Jerome ; de Ledinghen, Victor ; Ganne, Nathalie ; Metivier, Sophie ; Leroy, Vincent ; Rosa, Isabelle ; Mathurin, Philippe ; Cagnot, Carole ; Bonnet, Delphine ; Payssan-Sicart, Virginie ; Pomes, Chloe ; Bailly, François ; Giboz, Dominique ; Hartig-Lavie, Kerstin ; Maynard, Marianne ; Billaud, Eric ; Boutoille, David ; Cheraud-Carpentier, Marjorie ; Benhida, Jaouad ; Lannes, Adrien ; Lunel, Françoise ; Giuily, Nathalie ; Chibah, Aziza ; Bonardi, Karim ; Vallet-Pichard, Anaïs ; Foucher, Juliette ; Hiriart, Jean-Baptiste ; Chermak, Faiza ; Ansaldi, Christelle ; Amara, Nisserine Ben ; Chouquet, Laëtitia ; Anty, Rodolphe ; Gelsi, Eve ; Truchi, Régine ; Luckina, Elena ; Messaoudi, Nadia ; Moussali, Joseph ; De Dieuleveult, Barbara ; Poter, Pascal ; Ahmed, Si Nafa Si ; Grando-Lemaire, Véronique ; Nahon, Pierre ; Jezequel, Caroline ; Brener, Audrey ; Laligant, Anne ; Rabot, Aline ; Mutter, Catherine ; Simo-Noumbissie, Pauline ; Razi, Esma ; Bensenane, Mouni ; Nani, Abdelbasset ; Hassani-Nani, Sarah ; Bernard, Marie-Albertine ; Pageaux, Georges-Philippe ; Bismuth, Michael ; Bureau, Christophe ; Robic, Marie-Angèle ; Tarallo, Léa ; Froissart, Bruno ; Hilleret, Marie-Noelle ; Grard, Victorien ; François, Muriel ; Ouedraogo, Christian ; Pauleau, Christelle ; Varault, Anne ; Andreani, Tony ; Angoulevant, Bénédicte ; Chevance, Azeline ; Serfaty, Lawrence ; Coilly, Audrey ; Vallée, Jean-Charles Duclos ; Tateo, Mariagrazia ; Bonny, Corinne ; Brigitte, Chanteranne ; Muti, Léon ; Babouri, Abdenour ; Filipe, Virginie ; Babouri, Abdenour ; Costes, Laurent ; Hagège, Hervé ; Merbah, Soraya ; Carrier, Paul ; Artu, Florent ; Dharancy, Sébastien ; Louvet, Alexandre ; Mouillot, Thomas ; Barbereau, Didier ; Archambeaud, Isabelle ; Amara, Nisserine Ben ; Botta-Fridlund, Danièle ; Saillard, Eric ; Lafrance, Marie-Josée</creator><creatorcontrib>Vallet-Pichard, Anais ; Dorival, Celine ; Zoulim, Fabien ; Bourlière, Marc ; Calès, Paul ; Guyader, Dominique ; Bronowicki, Jean-Pierre ; Loustaud-Ratti, Veronique ; Gournay, Jerome ; de Ledinghen, Victor ; Ganne, Nathalie ; Metivier, Sophie ; Leroy, Vincent ; Rosa, Isabelle ; Mathurin, Philippe ; Cagnot, Carole ; Bonnet, Delphine ; Payssan-Sicart, Virginie ; Pomes, Chloe ; Bailly, François ; Giboz, Dominique ; Hartig-Lavie, Kerstin ; Maynard, Marianne ; Billaud, Eric ; Boutoille, David ; Cheraud-Carpentier, Marjorie ; Benhida, Jaouad ; Lannes, Adrien ; Lunel, Françoise ; Giuily, Nathalie ; Chibah, Aziza ; Bonardi, Karim ; Vallet-Pichard, Anaïs ; Foucher, Juliette ; Hiriart, Jean-Baptiste ; Chermak, Faiza ; Ansaldi, Christelle ; Amara, Nisserine Ben ; Chouquet, Laëtitia ; Anty, Rodolphe ; Gelsi, Eve ; Truchi, Régine ; Luckina, Elena ; Messaoudi, Nadia ; Moussali, Joseph ; De Dieuleveult, Barbara ; Poter, Pascal ; Ahmed, Si Nafa Si ; Grando-Lemaire, Véronique ; Nahon, Pierre ; Jezequel, Caroline ; Brener, Audrey ; Laligant, Anne ; Rabot, Aline ; Mutter, Catherine ; Simo-Noumbissie, Pauline ; Razi, Esma ; Bensenane, Mouni ; Nani, Abdelbasset ; Hassani-Nani, Sarah ; Bernard, Marie-Albertine ; Pageaux, Georges-Philippe ; Bismuth, Michael ; Bureau, Christophe ; Robic, Marie-Angèle ; Tarallo, Léa ; Froissart, Bruno ; Hilleret, Marie-Noelle ; Grard, Victorien ; François, Muriel ; Ouedraogo, Christian ; Pauleau, Christelle ; Varault, Anne ; Andreani, Tony ; Angoulevant, Bénédicte ; Chevance, Azeline ; Serfaty, Lawrence ; Coilly, Audrey ; Vallée, Jean-Charles Duclos ; Tateo, Mariagrazia ; Bonny, Corinne ; Brigitte, Chanteranne ; Muti, Léon ; Babouri, Abdenour ; Filipe, Virginie ; Babouri, Abdenour ; Costes, Laurent ; Hagège, Hervé ; Merbah, Soraya ; Carrier, Paul ; Artu, Florent ; Dharancy, Sébastien ; Louvet, Alexandre ; Mouillot, Thomas ; Barbereau, Didier ; Archambeaud, Isabelle ; Amara, Nisserine Ben ; Botta-Fridlund, Danièle ; Saillard, Eric ; Lafrance, Marie-Josée ; AFEF ANRS study group</creatorcontrib><description>•Our blinded analysis of HCC recurrence following “curative” treatment:•Argues against the “curative” efficacy of the first treatment of HCC in one third of patients.•Evidences that DAA therapy has no significant impact on the severity or progression of HCC recurrence.•Evidences that DAA therapy does not impact overall survival and could be considered in cirrhotic patients with prior history of HCC.
Although it has now been excluded that direct-acting antivirals (DAA) are associated with a significant risk of hepatocellular carcinoma (HCC) in HCV-infected patients, a possible effect of DAA on tumor growth is still a subject of debate. We performed a blind comparison of the kinetics of HCC recurrence in patients after HCV treatment with or without DAA to evaluate the potential aggressiveness of HCC after DAA treatment.
Thirty-nine HCV-infected patients from the AFEF/ANRS CO22 Hepather cohort who experienced HCC recurrence after so-called curative treatment were evaluated. Contrast-enhanced CT and/or MR images were read blindly 6 months before HCC recurrence and during the follow-up period. Seventeen patients who received DAA (DAA+) before HCC recurrence were compared to the 22 who did not receive (DAA−), according to the LiRads and mRECIST criteria.
There were 28 men and 11 women, median age 62 years old, 37 (95%) with cirrhosis. DAA+ patients had a lower median MELD score (8±2 vs. 10±4, P=0.0286) than DAA− patients. The median time to HCC recurrence (time from the date of curative treatment to the diagnosis of recurrence) was not different (20 vs. 18 months) (P=0.73) between the two groups. There was no difference between the 2 groups in the overall survival and/or transplantation-free survival (P=0.71) and for the mRECIST time to progression (P=0.25).
This blinded analysis of HCC recurrence after HCC treatment does not support any negative impact of DAA therapy on the severity or progression of recurrent HCC.</description><identifier>ISSN: 2210-7401</identifier><identifier>EISSN: 2210-741X</identifier><identifier>DOI: 10.1016/j.clinre.2020.04.022</identifier><identifier>PMID: 32595103</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Antiviral Agents - therapeutic use ; Carcinoma, Hepatocellular - drug therapy ; Direct-acting antivirals ; Female ; Hepacivirus ; Hepatitis C - drug therapy ; Hepatitis C virus ; Hepatitis C, Chronic - complications ; Hepatitis C, Chronic - drug therapy ; Hepatocellular carcinoma recurrence ; Human health and pathology ; Humans ; Life Sciences ; Liver Neoplasms - drug therapy ; Male ; Middle Aged ; Neoplasm Recurrence, Local - drug therapy ; Tumor growth</subject><ispartof>Clinics and research in hepatology and gastroenterology, 2021-01, Vol.45 (1), p.101459-101459, Article 101459</ispartof><rights>2020 Elsevier Masson SAS</rights><rights>Copyright © 2020 Elsevier Masson SAS. All rights reserved.</rights><rights>Attribution - NonCommercial</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-3167d8cfc03154994f664eca4b74e50527333d2f708430fa6638ba9e248435193</citedby><cites>FETCH-LOGICAL-c442t-3167d8cfc03154994f664eca4b74e50527333d2f708430fa6638ba9e248435193</cites><orcidid>0000-0002-2245-0083 ; 0000-0001-6414-1951 ; 0000-0003-3447-2025 ; 0000-0003-4866-5274 ; 0000-0002-0892-3489 ; 0000-0001-9772-9591 ; 0000-0002-3061-1422 ; 0000-0002-8672-7918</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinre.2020.04.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32595103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02921184$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Vallet-Pichard, Anais</creatorcontrib><creatorcontrib>Dorival, Celine</creatorcontrib><creatorcontrib>Zoulim, Fabien</creatorcontrib><creatorcontrib>Bourlière, Marc</creatorcontrib><creatorcontrib>Calès, Paul</creatorcontrib><creatorcontrib>Guyader, Dominique</creatorcontrib><creatorcontrib>Bronowicki, Jean-Pierre</creatorcontrib><creatorcontrib>Loustaud-Ratti, Veronique</creatorcontrib><creatorcontrib>Gournay, Jerome</creatorcontrib><creatorcontrib>de Ledinghen, Victor</creatorcontrib><creatorcontrib>Ganne, Nathalie</creatorcontrib><creatorcontrib>Metivier, Sophie</creatorcontrib><creatorcontrib>Leroy, Vincent</creatorcontrib><creatorcontrib>Rosa, Isabelle</creatorcontrib><creatorcontrib>Mathurin, Philippe</creatorcontrib><creatorcontrib>Cagnot, Carole</creatorcontrib><creatorcontrib>Bonnet, Delphine</creatorcontrib><creatorcontrib>Payssan-Sicart, Virginie</creatorcontrib><creatorcontrib>Pomes, Chloe</creatorcontrib><creatorcontrib>Bailly, François</creatorcontrib><creatorcontrib>Giboz, Dominique</creatorcontrib><creatorcontrib>Hartig-Lavie, Kerstin</creatorcontrib><creatorcontrib>Maynard, Marianne</creatorcontrib><creatorcontrib>Billaud, Eric</creatorcontrib><creatorcontrib>Boutoille, David</creatorcontrib><creatorcontrib>Cheraud-Carpentier, Marjorie</creatorcontrib><creatorcontrib>Benhida, Jaouad</creatorcontrib><creatorcontrib>Lannes, Adrien</creatorcontrib><creatorcontrib>Lunel, Françoise</creatorcontrib><creatorcontrib>Giuily, Nathalie</creatorcontrib><creatorcontrib>Chibah, Aziza</creatorcontrib><creatorcontrib>Bonardi, Karim</creatorcontrib><creatorcontrib>Vallet-Pichard, Anaïs</creatorcontrib><creatorcontrib>Foucher, Juliette</creatorcontrib><creatorcontrib>Hiriart, Jean-Baptiste</creatorcontrib><creatorcontrib>Chermak, Faiza</creatorcontrib><creatorcontrib>Ansaldi, Christelle</creatorcontrib><creatorcontrib>Amara, Nisserine Ben</creatorcontrib><creatorcontrib>Chouquet, Laëtitia</creatorcontrib><creatorcontrib>Anty, Rodolphe</creatorcontrib><creatorcontrib>Gelsi, Eve</creatorcontrib><creatorcontrib>Truchi, Régine</creatorcontrib><creatorcontrib>Luckina, Elena</creatorcontrib><creatorcontrib>Messaoudi, Nadia</creatorcontrib><creatorcontrib>Moussali, Joseph</creatorcontrib><creatorcontrib>De Dieuleveult, Barbara</creatorcontrib><creatorcontrib>Poter, Pascal</creatorcontrib><creatorcontrib>Ahmed, Si Nafa Si</creatorcontrib><creatorcontrib>Grando-Lemaire, Véronique</creatorcontrib><creatorcontrib>Nahon, Pierre</creatorcontrib><creatorcontrib>Jezequel, Caroline</creatorcontrib><creatorcontrib>Brener, Audrey</creatorcontrib><creatorcontrib>Laligant, Anne</creatorcontrib><creatorcontrib>Rabot, Aline</creatorcontrib><creatorcontrib>Mutter, Catherine</creatorcontrib><creatorcontrib>Simo-Noumbissie, Pauline</creatorcontrib><creatorcontrib>Razi, Esma</creatorcontrib><creatorcontrib>Bensenane, Mouni</creatorcontrib><creatorcontrib>Nani, Abdelbasset</creatorcontrib><creatorcontrib>Hassani-Nani, Sarah</creatorcontrib><creatorcontrib>Bernard, Marie-Albertine</creatorcontrib><creatorcontrib>Pageaux, Georges-Philippe</creatorcontrib><creatorcontrib>Bismuth, Michael</creatorcontrib><creatorcontrib>Bureau, Christophe</creatorcontrib><creatorcontrib>Robic, Marie-Angèle</creatorcontrib><creatorcontrib>Tarallo, Léa</creatorcontrib><creatorcontrib>Froissart, Bruno</creatorcontrib><creatorcontrib>Hilleret, Marie-Noelle</creatorcontrib><creatorcontrib>Grard, Victorien</creatorcontrib><creatorcontrib>François, Muriel</creatorcontrib><creatorcontrib>Ouedraogo, Christian</creatorcontrib><creatorcontrib>Pauleau, Christelle</creatorcontrib><creatorcontrib>Varault, Anne</creatorcontrib><creatorcontrib>Andreani, Tony</creatorcontrib><creatorcontrib>Angoulevant, Bénédicte</creatorcontrib><creatorcontrib>Chevance, Azeline</creatorcontrib><creatorcontrib>Serfaty, Lawrence</creatorcontrib><creatorcontrib>Coilly, Audrey</creatorcontrib><creatorcontrib>Vallée, Jean-Charles Duclos</creatorcontrib><creatorcontrib>Tateo, Mariagrazia</creatorcontrib><creatorcontrib>Bonny, Corinne</creatorcontrib><creatorcontrib>Brigitte, Chanteranne</creatorcontrib><creatorcontrib>Muti, Léon</creatorcontrib><creatorcontrib>Babouri, Abdenour</creatorcontrib><creatorcontrib>Filipe, Virginie</creatorcontrib><creatorcontrib>Babouri, Abdenour</creatorcontrib><creatorcontrib>Costes, Laurent</creatorcontrib><creatorcontrib>Hagège, Hervé</creatorcontrib><creatorcontrib>Merbah, Soraya</creatorcontrib><creatorcontrib>Carrier, Paul</creatorcontrib><creatorcontrib>Artu, Florent</creatorcontrib><creatorcontrib>Dharancy, Sébastien</creatorcontrib><creatorcontrib>Louvet, Alexandre</creatorcontrib><creatorcontrib>Mouillot, Thomas</creatorcontrib><creatorcontrib>Barbereau, Didier</creatorcontrib><creatorcontrib>Archambeaud, Isabelle</creatorcontrib><creatorcontrib>Amara, Nisserine Ben</creatorcontrib><creatorcontrib>Botta-Fridlund, Danièle</creatorcontrib><creatorcontrib>Saillard, Eric</creatorcontrib><creatorcontrib>Lafrance, Marie-Josée</creatorcontrib><creatorcontrib>AFEF ANRS study group</creatorcontrib><title>Absence of impact of direct acting antivirals for hepatitis C virus on recurrent hepatocellular carcinoma tumor growth in the AFEF/ANRS CO22 Hepather cohort</title><title>Clinics and research in hepatology and gastroenterology</title><addtitle>Clin Res Hepatol Gastroenterol</addtitle><description>•Our blinded analysis of HCC recurrence following “curative” treatment:•Argues against the “curative” efficacy of the first treatment of HCC in one third of patients.•Evidences that DAA therapy has no significant impact on the severity or progression of HCC recurrence.•Evidences that DAA therapy does not impact overall survival and could be considered in cirrhotic patients with prior history of HCC.
Although it has now been excluded that direct-acting antivirals (DAA) are associated with a significant risk of hepatocellular carcinoma (HCC) in HCV-infected patients, a possible effect of DAA on tumor growth is still a subject of debate. We performed a blind comparison of the kinetics of HCC recurrence in patients after HCV treatment with or without DAA to evaluate the potential aggressiveness of HCC after DAA treatment.
Thirty-nine HCV-infected patients from the AFEF/ANRS CO22 Hepather cohort who experienced HCC recurrence after so-called curative treatment were evaluated. Contrast-enhanced CT and/or MR images were read blindly 6 months before HCC recurrence and during the follow-up period. Seventeen patients who received DAA (DAA+) before HCC recurrence were compared to the 22 who did not receive (DAA−), according to the LiRads and mRECIST criteria.
There were 28 men and 11 women, median age 62 years old, 37 (95%) with cirrhosis. DAA+ patients had a lower median MELD score (8±2 vs. 10±4, P=0.0286) than DAA− patients. The median time to HCC recurrence (time from the date of curative treatment to the diagnosis of recurrence) was not different (20 vs. 18 months) (P=0.73) between the two groups. There was no difference between the 2 groups in the overall survival and/or transplantation-free survival (P=0.71) and for the mRECIST time to progression (P=0.25).
This blinded analysis of HCC recurrence after HCC treatment does not support any negative impact of DAA therapy on the severity or progression of recurrent HCC.</description><subject>Antiviral Agents - therapeutic use</subject><subject>Carcinoma, Hepatocellular - drug therapy</subject><subject>Direct-acting antivirals</subject><subject>Female</subject><subject>Hepacivirus</subject><subject>Hepatitis C - drug therapy</subject><subject>Hepatitis C virus</subject><subject>Hepatitis C, Chronic - complications</subject><subject>Hepatitis C, Chronic - drug therapy</subject><subject>Hepatocellular carcinoma recurrence</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - drug therapy</subject><subject>Tumor growth</subject><issn>2210-7401</issn><issn>2210-741X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1q3DAUhU1paUKaNwhFy3YxztWP_zYFM2Q6haGBpIXshEa-jjXY1lSSJ_Rd-rCVcTrLaqN7pe_cg3SS5IZCSoHmt4dU92Z0mDJgkIJIgbE3ySVjFFaFoE9vzzXQi-Ta-wPEJTIoC_o-ueAsqzIK_DL5U-89jhqJbYkZjkqHuWqMw1jFzozPRI3BnIxTvSetdaTDowomGE_WJB5PntiRRH5yDsewXFuNfT_1yhGtnDajHRQJ0xDVz86-hI6YkYQOSb2529zW3x8eyfqeMbKdtR1Gle2sCx-Sd210xevX_Sr5ubn7sd6udvdfv63r3UoLwcKK07xoSt1q4DQTVSXaPBeoldgXAjPIWME5b1hbQCk4tCrPeblXFTIR-4xW_Cr5vMztVC-PzgzK_ZZWGbmtd3I-A1YxSktxopH9tLBHZ39N6IMcjJ9fq0a0k5dM0LLgUDIeUbGg2lnvHbbn2RTkHKM8yCVGOccoQUQjFmUfXx2m_YDNWfQvtAh8WQCMf3Iy6KTXZg5xiU021vzf4S9TXq7x</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Vallet-Pichard, Anais</creator><creator>Dorival, Celine</creator><creator>Zoulim, Fabien</creator><creator>Bourlière, Marc</creator><creator>Calès, Paul</creator><creator>Guyader, Dominique</creator><creator>Bronowicki, Jean-Pierre</creator><creator>Loustaud-Ratti, Veronique</creator><creator>Gournay, Jerome</creator><creator>de Ledinghen, Victor</creator><creator>Ganne, Nathalie</creator><creator>Metivier, Sophie</creator><creator>Leroy, Vincent</creator><creator>Rosa, Isabelle</creator><creator>Mathurin, Philippe</creator><creator>Cagnot, Carole</creator><creator>Bonnet, Delphine</creator><creator>Payssan-Sicart, Virginie</creator><creator>Pomes, Chloe</creator><creator>Bailly, François</creator><creator>Giboz, Dominique</creator><creator>Hartig-Lavie, Kerstin</creator><creator>Maynard, Marianne</creator><creator>Billaud, Eric</creator><creator>Boutoille, David</creator><creator>Cheraud-Carpentier, Marjorie</creator><creator>Benhida, Jaouad</creator><creator>Lannes, Adrien</creator><creator>Lunel, Françoise</creator><creator>Giuily, Nathalie</creator><creator>Chibah, Aziza</creator><creator>Bonardi, Karim</creator><creator>Vallet-Pichard, Anaïs</creator><creator>Foucher, Juliette</creator><creator>Hiriart, Jean-Baptiste</creator><creator>Chermak, Faiza</creator><creator>Ansaldi, Christelle</creator><creator>Amara, Nisserine Ben</creator><creator>Chouquet, Laëtitia</creator><creator>Anty, Rodolphe</creator><creator>Gelsi, Eve</creator><creator>Truchi, Régine</creator><creator>Luckina, Elena</creator><creator>Messaoudi, Nadia</creator><creator>Moussali, Joseph</creator><creator>De Dieuleveult, Barbara</creator><creator>Poter, Pascal</creator><creator>Ahmed, Si Nafa Si</creator><creator>Grando-Lemaire, Véronique</creator><creator>Nahon, Pierre</creator><creator>Jezequel, Caroline</creator><creator>Brener, Audrey</creator><creator>Laligant, Anne</creator><creator>Rabot, Aline</creator><creator>Mutter, Catherine</creator><creator>Simo-Noumbissie, Pauline</creator><creator>Razi, Esma</creator><creator>Bensenane, Mouni</creator><creator>Nani, Abdelbasset</creator><creator>Hassani-Nani, Sarah</creator><creator>Bernard, Marie-Albertine</creator><creator>Pageaux, Georges-Philippe</creator><creator>Bismuth, Michael</creator><creator>Bureau, Christophe</creator><creator>Robic, Marie-Angèle</creator><creator>Tarallo, Léa</creator><creator>Froissart, Bruno</creator><creator>Hilleret, Marie-Noelle</creator><creator>Grard, Victorien</creator><creator>François, Muriel</creator><creator>Ouedraogo, Christian</creator><creator>Pauleau, Christelle</creator><creator>Varault, Anne</creator><creator>Andreani, Tony</creator><creator>Angoulevant, Bénédicte</creator><creator>Chevance, Azeline</creator><creator>Serfaty, Lawrence</creator><creator>Coilly, Audrey</creator><creator>Vallée, Jean-Charles Duclos</creator><creator>Tateo, Mariagrazia</creator><creator>Bonny, Corinne</creator><creator>Brigitte, Chanteranne</creator><creator>Muti, Léon</creator><creator>Babouri, Abdenour</creator><creator>Filipe, Virginie</creator><creator>Babouri, Abdenour</creator><creator>Costes, Laurent</creator><creator>Hagège, Hervé</creator><creator>Merbah, Soraya</creator><creator>Carrier, Paul</creator><creator>Artu, Florent</creator><creator>Dharancy, Sébastien</creator><creator>Louvet, Alexandre</creator><creator>Mouillot, Thomas</creator><creator>Barbereau, Didier</creator><creator>Archambeaud, Isabelle</creator><creator>Amara, Nisserine Ben</creator><creator>Botta-Fridlund, Danièle</creator><creator>Saillard, Eric</creator><creator>Lafrance, Marie-Josée</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-2245-0083</orcidid><orcidid>https://orcid.org/0000-0001-6414-1951</orcidid><orcidid>https://orcid.org/0000-0003-3447-2025</orcidid><orcidid>https://orcid.org/0000-0003-4866-5274</orcidid><orcidid>https://orcid.org/0000-0002-0892-3489</orcidid><orcidid>https://orcid.org/0000-0001-9772-9591</orcidid><orcidid>https://orcid.org/0000-0002-3061-1422</orcidid><orcidid>https://orcid.org/0000-0002-8672-7918</orcidid></search><sort><creationdate>20210101</creationdate><title>Absence of impact of direct acting antivirals for hepatitis C virus on recurrent hepatocellular carcinoma tumor growth in the AFEF/ANRS CO22 Hepather cohort</title><author>Vallet-Pichard, Anais ; Dorival, Celine ; Zoulim, Fabien ; Bourlière, Marc ; Calès, Paul ; Guyader, Dominique ; Bronowicki, Jean-Pierre ; Loustaud-Ratti, Veronique ; Gournay, Jerome ; de Ledinghen, Victor ; Ganne, Nathalie ; Metivier, Sophie ; Leroy, Vincent ; Rosa, Isabelle ; Mathurin, Philippe ; Cagnot, Carole ; Bonnet, Delphine ; Payssan-Sicart, Virginie ; Pomes, Chloe ; Bailly, François ; Giboz, Dominique ; Hartig-Lavie, Kerstin ; Maynard, Marianne ; Billaud, Eric ; Boutoille, David ; Cheraud-Carpentier, Marjorie ; Benhida, Jaouad ; Lannes, Adrien ; Lunel, Françoise ; Giuily, Nathalie ; Chibah, Aziza ; Bonardi, Karim ; Vallet-Pichard, Anaïs ; Foucher, Juliette ; Hiriart, Jean-Baptiste ; Chermak, Faiza ; Ansaldi, Christelle ; Amara, Nisserine Ben ; Chouquet, Laëtitia ; Anty, Rodolphe ; Gelsi, Eve ; Truchi, Régine ; Luckina, Elena ; Messaoudi, Nadia ; Moussali, Joseph ; De Dieuleveult, Barbara ; Poter, Pascal ; Ahmed, Si Nafa Si ; Grando-Lemaire, Véronique ; Nahon, Pierre ; Jezequel, Caroline ; Brener, Audrey ; Laligant, Anne ; Rabot, Aline ; Mutter, Catherine ; Simo-Noumbissie, Pauline ; Razi, Esma ; Bensenane, Mouni ; Nani, Abdelbasset ; Hassani-Nani, Sarah ; Bernard, Marie-Albertine ; Pageaux, Georges-Philippe ; Bismuth, Michael ; Bureau, Christophe ; Robic, Marie-Angèle ; Tarallo, Léa ; Froissart, Bruno ; Hilleret, Marie-Noelle ; Grard, Victorien ; François, Muriel ; Ouedraogo, Christian ; Pauleau, Christelle ; Varault, Anne ; Andreani, Tony ; Angoulevant, Bénédicte ; Chevance, Azeline ; Serfaty, Lawrence ; Coilly, Audrey ; Vallée, Jean-Charles Duclos ; Tateo, Mariagrazia ; Bonny, Corinne ; Brigitte, Chanteranne ; Muti, Léon ; Babouri, Abdenour ; Filipe, Virginie ; Babouri, Abdenour ; Costes, Laurent ; Hagège, Hervé ; Merbah, Soraya ; Carrier, Paul ; Artu, Florent ; Dharancy, Sébastien ; Louvet, Alexandre ; Mouillot, Thomas ; Barbereau, Didier ; Archambeaud, Isabelle ; Amara, Nisserine Ben ; Botta-Fridlund, Danièle ; Saillard, Eric ; Lafrance, Marie-Josée</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-3167d8cfc03154994f664eca4b74e50527333d2f708430fa6638ba9e248435193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antiviral Agents - therapeutic use</topic><topic>Carcinoma, Hepatocellular - drug therapy</topic><topic>Direct-acting antivirals</topic><topic>Female</topic><topic>Hepacivirus</topic><topic>Hepatitis C - drug therapy</topic><topic>Hepatitis C virus</topic><topic>Hepatitis C, Chronic - complications</topic><topic>Hepatitis C, Chronic - drug therapy</topic><topic>Hepatocellular carcinoma recurrence</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - drug therapy</topic><topic>Tumor growth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vallet-Pichard, Anais</creatorcontrib><creatorcontrib>Dorival, Celine</creatorcontrib><creatorcontrib>Zoulim, Fabien</creatorcontrib><creatorcontrib>Bourlière, Marc</creatorcontrib><creatorcontrib>Calès, Paul</creatorcontrib><creatorcontrib>Guyader, Dominique</creatorcontrib><creatorcontrib>Bronowicki, Jean-Pierre</creatorcontrib><creatorcontrib>Loustaud-Ratti, Veronique</creatorcontrib><creatorcontrib>Gournay, Jerome</creatorcontrib><creatorcontrib>de Ledinghen, Victor</creatorcontrib><creatorcontrib>Ganne, Nathalie</creatorcontrib><creatorcontrib>Metivier, Sophie</creatorcontrib><creatorcontrib>Leroy, Vincent</creatorcontrib><creatorcontrib>Rosa, Isabelle</creatorcontrib><creatorcontrib>Mathurin, Philippe</creatorcontrib><creatorcontrib>Cagnot, Carole</creatorcontrib><creatorcontrib>Bonnet, Delphine</creatorcontrib><creatorcontrib>Payssan-Sicart, Virginie</creatorcontrib><creatorcontrib>Pomes, Chloe</creatorcontrib><creatorcontrib>Bailly, François</creatorcontrib><creatorcontrib>Giboz, Dominique</creatorcontrib><creatorcontrib>Hartig-Lavie, Kerstin</creatorcontrib><creatorcontrib>Maynard, Marianne</creatorcontrib><creatorcontrib>Billaud, Eric</creatorcontrib><creatorcontrib>Boutoille, David</creatorcontrib><creatorcontrib>Cheraud-Carpentier, Marjorie</creatorcontrib><creatorcontrib>Benhida, Jaouad</creatorcontrib><creatorcontrib>Lannes, Adrien</creatorcontrib><creatorcontrib>Lunel, Françoise</creatorcontrib><creatorcontrib>Giuily, Nathalie</creatorcontrib><creatorcontrib>Chibah, Aziza</creatorcontrib><creatorcontrib>Bonardi, Karim</creatorcontrib><creatorcontrib>Vallet-Pichard, Anaïs</creatorcontrib><creatorcontrib>Foucher, Juliette</creatorcontrib><creatorcontrib>Hiriart, Jean-Baptiste</creatorcontrib><creatorcontrib>Chermak, Faiza</creatorcontrib><creatorcontrib>Ansaldi, Christelle</creatorcontrib><creatorcontrib>Amara, Nisserine Ben</creatorcontrib><creatorcontrib>Chouquet, Laëtitia</creatorcontrib><creatorcontrib>Anty, Rodolphe</creatorcontrib><creatorcontrib>Gelsi, Eve</creatorcontrib><creatorcontrib>Truchi, Régine</creatorcontrib><creatorcontrib>Luckina, Elena</creatorcontrib><creatorcontrib>Messaoudi, Nadia</creatorcontrib><creatorcontrib>Moussali, Joseph</creatorcontrib><creatorcontrib>De Dieuleveult, Barbara</creatorcontrib><creatorcontrib>Poter, Pascal</creatorcontrib><creatorcontrib>Ahmed, Si Nafa Si</creatorcontrib><creatorcontrib>Grando-Lemaire, Véronique</creatorcontrib><creatorcontrib>Nahon, Pierre</creatorcontrib><creatorcontrib>Jezequel, Caroline</creatorcontrib><creatorcontrib>Brener, Audrey</creatorcontrib><creatorcontrib>Laligant, Anne</creatorcontrib><creatorcontrib>Rabot, Aline</creatorcontrib><creatorcontrib>Mutter, Catherine</creatorcontrib><creatorcontrib>Simo-Noumbissie, Pauline</creatorcontrib><creatorcontrib>Razi, Esma</creatorcontrib><creatorcontrib>Bensenane, Mouni</creatorcontrib><creatorcontrib>Nani, Abdelbasset</creatorcontrib><creatorcontrib>Hassani-Nani, Sarah</creatorcontrib><creatorcontrib>Bernard, Marie-Albertine</creatorcontrib><creatorcontrib>Pageaux, Georges-Philippe</creatorcontrib><creatorcontrib>Bismuth, Michael</creatorcontrib><creatorcontrib>Bureau, Christophe</creatorcontrib><creatorcontrib>Robic, Marie-Angèle</creatorcontrib><creatorcontrib>Tarallo, Léa</creatorcontrib><creatorcontrib>Froissart, Bruno</creatorcontrib><creatorcontrib>Hilleret, Marie-Noelle</creatorcontrib><creatorcontrib>Grard, Victorien</creatorcontrib><creatorcontrib>François, Muriel</creatorcontrib><creatorcontrib>Ouedraogo, Christian</creatorcontrib><creatorcontrib>Pauleau, Christelle</creatorcontrib><creatorcontrib>Varault, Anne</creatorcontrib><creatorcontrib>Andreani, Tony</creatorcontrib><creatorcontrib>Angoulevant, Bénédicte</creatorcontrib><creatorcontrib>Chevance, Azeline</creatorcontrib><creatorcontrib>Serfaty, Lawrence</creatorcontrib><creatorcontrib>Coilly, Audrey</creatorcontrib><creatorcontrib>Vallée, Jean-Charles Duclos</creatorcontrib><creatorcontrib>Tateo, Mariagrazia</creatorcontrib><creatorcontrib>Bonny, Corinne</creatorcontrib><creatorcontrib>Brigitte, Chanteranne</creatorcontrib><creatorcontrib>Muti, Léon</creatorcontrib><creatorcontrib>Babouri, Abdenour</creatorcontrib><creatorcontrib>Filipe, Virginie</creatorcontrib><creatorcontrib>Babouri, Abdenour</creatorcontrib><creatorcontrib>Costes, Laurent</creatorcontrib><creatorcontrib>Hagège, Hervé</creatorcontrib><creatorcontrib>Merbah, Soraya</creatorcontrib><creatorcontrib>Carrier, Paul</creatorcontrib><creatorcontrib>Artu, Florent</creatorcontrib><creatorcontrib>Dharancy, Sébastien</creatorcontrib><creatorcontrib>Louvet, Alexandre</creatorcontrib><creatorcontrib>Mouillot, Thomas</creatorcontrib><creatorcontrib>Barbereau, Didier</creatorcontrib><creatorcontrib>Archambeaud, Isabelle</creatorcontrib><creatorcontrib>Amara, Nisserine Ben</creatorcontrib><creatorcontrib>Botta-Fridlund, Danièle</creatorcontrib><creatorcontrib>Saillard, Eric</creatorcontrib><creatorcontrib>Lafrance, Marie-Josée</creatorcontrib><creatorcontrib>AFEF ANRS study group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Clinics and research in hepatology and gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vallet-Pichard, Anais</au><au>Dorival, Celine</au><au>Zoulim, Fabien</au><au>Bourlière, Marc</au><au>Calès, Paul</au><au>Guyader, Dominique</au><au>Bronowicki, Jean-Pierre</au><au>Loustaud-Ratti, Veronique</au><au>Gournay, Jerome</au><au>de Ledinghen, Victor</au><au>Ganne, Nathalie</au><au>Metivier, Sophie</au><au>Leroy, Vincent</au><au>Rosa, Isabelle</au><au>Mathurin, Philippe</au><au>Cagnot, Carole</au><au>Bonnet, Delphine</au><au>Payssan-Sicart, Virginie</au><au>Pomes, Chloe</au><au>Bailly, François</au><au>Giboz, Dominique</au><au>Hartig-Lavie, Kerstin</au><au>Maynard, Marianne</au><au>Billaud, Eric</au><au>Boutoille, David</au><au>Cheraud-Carpentier, Marjorie</au><au>Benhida, Jaouad</au><au>Lannes, Adrien</au><au>Lunel, Françoise</au><au>Giuily, Nathalie</au><au>Chibah, Aziza</au><au>Bonardi, Karim</au><au>Vallet-Pichard, Anaïs</au><au>Foucher, Juliette</au><au>Hiriart, Jean-Baptiste</au><au>Chermak, Faiza</au><au>Ansaldi, Christelle</au><au>Amara, Nisserine Ben</au><au>Chouquet, Laëtitia</au><au>Anty, Rodolphe</au><au>Gelsi, Eve</au><au>Truchi, Régine</au><au>Luckina, Elena</au><au>Messaoudi, Nadia</au><au>Moussali, Joseph</au><au>De Dieuleveult, Barbara</au><au>Poter, Pascal</au><au>Ahmed, Si Nafa Si</au><au>Grando-Lemaire, Véronique</au><au>Nahon, Pierre</au><au>Jezequel, Caroline</au><au>Brener, Audrey</au><au>Laligant, Anne</au><au>Rabot, Aline</au><au>Mutter, Catherine</au><au>Simo-Noumbissie, Pauline</au><au>Razi, Esma</au><au>Bensenane, Mouni</au><au>Nani, Abdelbasset</au><au>Hassani-Nani, Sarah</au><au>Bernard, Marie-Albertine</au><au>Pageaux, Georges-Philippe</au><au>Bismuth, Michael</au><au>Bureau, Christophe</au><au>Robic, Marie-Angèle</au><au>Tarallo, Léa</au><au>Froissart, Bruno</au><au>Hilleret, Marie-Noelle</au><au>Grard, Victorien</au><au>François, Muriel</au><au>Ouedraogo, Christian</au><au>Pauleau, Christelle</au><au>Varault, Anne</au><au>Andreani, Tony</au><au>Angoulevant, Bénédicte</au><au>Chevance, Azeline</au><au>Serfaty, Lawrence</au><au>Coilly, Audrey</au><au>Vallée, Jean-Charles Duclos</au><au>Tateo, Mariagrazia</au><au>Bonny, Corinne</au><au>Brigitte, Chanteranne</au><au>Muti, Léon</au><au>Babouri, Abdenour</au><au>Filipe, Virginie</au><au>Babouri, Abdenour</au><au>Costes, Laurent</au><au>Hagège, Hervé</au><au>Merbah, Soraya</au><au>Carrier, Paul</au><au>Artu, Florent</au><au>Dharancy, Sébastien</au><au>Louvet, Alexandre</au><au>Mouillot, Thomas</au><au>Barbereau, Didier</au><au>Archambeaud, Isabelle</au><au>Amara, Nisserine Ben</au><au>Botta-Fridlund, Danièle</au><au>Saillard, Eric</au><au>Lafrance, Marie-Josée</au><aucorp>AFEF ANRS study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Absence of impact of direct acting antivirals for hepatitis C virus on recurrent hepatocellular carcinoma tumor growth in the AFEF/ANRS CO22 Hepather cohort</atitle><jtitle>Clinics and research in hepatology and gastroenterology</jtitle><addtitle>Clin Res Hepatol Gastroenterol</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>45</volume><issue>1</issue><spage>101459</spage><epage>101459</epage><pages>101459-101459</pages><artnum>101459</artnum><issn>2210-7401</issn><eissn>2210-741X</eissn><abstract>•Our blinded analysis of HCC recurrence following “curative” treatment:•Argues against the “curative” efficacy of the first treatment of HCC in one third of patients.•Evidences that DAA therapy has no significant impact on the severity or progression of HCC recurrence.•Evidences that DAA therapy does not impact overall survival and could be considered in cirrhotic patients with prior history of HCC.
Although it has now been excluded that direct-acting antivirals (DAA) are associated with a significant risk of hepatocellular carcinoma (HCC) in HCV-infected patients, a possible effect of DAA on tumor growth is still a subject of debate. We performed a blind comparison of the kinetics of HCC recurrence in patients after HCV treatment with or without DAA to evaluate the potential aggressiveness of HCC after DAA treatment.
Thirty-nine HCV-infected patients from the AFEF/ANRS CO22 Hepather cohort who experienced HCC recurrence after so-called curative treatment were evaluated. Contrast-enhanced CT and/or MR images were read blindly 6 months before HCC recurrence and during the follow-up period. Seventeen patients who received DAA (DAA+) before HCC recurrence were compared to the 22 who did not receive (DAA−), according to the LiRads and mRECIST criteria.
There were 28 men and 11 women, median age 62 years old, 37 (95%) with cirrhosis. DAA+ patients had a lower median MELD score (8±2 vs. 10±4, P=0.0286) than DAA− patients. The median time to HCC recurrence (time from the date of curative treatment to the diagnosis of recurrence) was not different (20 vs. 18 months) (P=0.73) between the two groups. There was no difference between the 2 groups in the overall survival and/or transplantation-free survival (P=0.71) and for the mRECIST time to progression (P=0.25).
This blinded analysis of HCC recurrence after HCC treatment does not support any negative impact of DAA therapy on the severity or progression of recurrent HCC.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>32595103</pmid><doi>10.1016/j.clinre.2020.04.022</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-2245-0083</orcidid><orcidid>https://orcid.org/0000-0001-6414-1951</orcidid><orcidid>https://orcid.org/0000-0003-3447-2025</orcidid><orcidid>https://orcid.org/0000-0003-4866-5274</orcidid><orcidid>https://orcid.org/0000-0002-0892-3489</orcidid><orcidid>https://orcid.org/0000-0001-9772-9591</orcidid><orcidid>https://orcid.org/0000-0002-3061-1422</orcidid><orcidid>https://orcid.org/0000-0002-8672-7918</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2210-7401 |
| ispartof | Clinics and research in hepatology and gastroenterology, 2021-01, Vol.45 (1), p.101459-101459, Article 101459 |
| issn | 2210-7401 2210-741X |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02921184v1 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Antiviral Agents - therapeutic use Carcinoma, Hepatocellular - drug therapy Direct-acting antivirals Female Hepacivirus Hepatitis C - drug therapy Hepatitis C virus Hepatitis C, Chronic - complications Hepatitis C, Chronic - drug therapy Hepatocellular carcinoma recurrence Human health and pathology Humans Life Sciences Liver Neoplasms - drug therapy Male Middle Aged Neoplasm Recurrence, Local - drug therapy Tumor growth |
| title | Absence of impact of direct acting antivirals for hepatitis C virus on recurrent hepatocellular carcinoma tumor growth in the AFEF/ANRS CO22 Hepather cohort |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T18%3A55%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Absence%20of%20impact%20of%20direct%20acting%20antivirals%20for%20hepatitis%20C%20virus%20on%20recurrent%20hepatocellular%20carcinoma%20tumor%20growth%20in%20the%20AFEF/ANRS%20CO22%20Hepather%20cohort&rft.jtitle=Clinics%20and%20research%20in%20hepatology%20and%20gastroenterology&rft.au=Vallet-Pichard,%20Anais&rft.aucorp=AFEF%20ANRS%20study%20group&rft.date=2021-01-01&rft.volume=45&rft.issue=1&rft.spage=101459&rft.epage=101459&rft.pages=101459-101459&rft.artnum=101459&rft.issn=2210-7401&rft.eissn=2210-741X&rft_id=info:doi/10.1016/j.clinre.2020.04.022&rft_dat=%3Cproquest_hal_p%3E2418730823%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2418730823&rft_id=info:pmid/32595103&rft_els_id=S2210740120301522&rfr_iscdi=true |