Porphyrin Derivatives Inhibit the Interaction between Receptor Activator of NF‐κB and Its Ligand

Receptor activator of NF‐κB (RANK), a member of the TNF‐receptor superfamily, plays an important role in bone resorption and stimulates immune and epithelial cell activation. Denosumab, a human monoclonal antibody that blocks the RANK ligand (RANKL), is approved for the treatment of osteoporosis and...

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Veröffentlicht in:	ChemMedChem 2017-10, Vol.12 (20), p.1697-1702
Hauptverfasser:	Chypre, Mélanie, Madel, Maria‐Bernadette, Chaloin, Olivier, Blin‐Wakkach, Claudine, Morice, Christophe, Mueller, Christopher G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival cell-based assays ELISA Humans Jurkat Cells Life Sciences Mice Molecular Structure osteoclasts Osteogenesis - drug effects Pharmaceutical sciences porphyrins Porphyrins - chemistry Porphyrins - pharmacology Protein Binding RANK Ligand - antagonists & inhibitors RANK Ligand - chemistry RANK Ligand - metabolism receptor activator of NF-κB Receptor Activator of Nuclear Factor-kappa B - antagonists & inhibitors Receptor Activator of Nuclear Factor-kappa B - chemistry Receptor Activator of Nuclear Factor-kappa B - metabolism Structure-Activity Relationship
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