Microwell-based pancreas-on-chip model enhances genes expression and functionality of rat islets of Langerhans

Organ-on-chip technology is a promising tool for investigating physiological in vitro responses in drug screening development, and in advanced disease models. Within this framework, we investigated the behavior of rat islets of Langerhans in an organ-on-chip model. The islets were trapped by sedimen...

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Veröffentlicht in:	Molecular and cellular endocrinology 2020-08, Vol.514, p.110892-110892, Article 110892
Hauptverfasser:	Essaouiba, Amal, Okitsu, Teru, Jellali, Rachid, Shinohara, Marie, Danoy, Mathieu, Tauran, Yannick, Legallais, Cécile, Sakai, Yasuyuki, Leclerc, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioengineering Biomechanics Glucagon Glucose homeostasis Insulin Islets of langerhans Life Sciences Mechanics Microfluidic biochips Pancreas Physics
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