Clonal interference of signaling mutations worsens prognosis in core-binding factor acute myeloid leukemia

Mutations in receptor tyrosine kinase/RAS signaling pathway genes are frequent in core-binding factor (CBF) acute myeloid leukemias (AMLs), but their prognostic relevance is debated. A subset of CBF AML patients harbors several signaling gene mutations. Genotyping of colonies and of relapse samples...

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Veröffentlicht in:	Blood 2018-07, Vol.132 (2), p.187-196
Hauptverfasser:	Itzykson, Raphael, Duployez, Nicolas, Fasan, Annette, Decool, Gauthier, Marceau-Renaut, Alice, Meggendorfer, Manja, Jourdan, Eric, Petit, Arnaud, Lapillonne, Hélène, Micol, Jean-Baptiste, Cornillet-Lefebvre, Pascale, Ifrah, Norbert, Leverger, Guy, Dombret, Hervé, Boissel, Nicolas, Haferlach, Torsten, Preudhomme, Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Biomarkers, Tumor Child Child, Preschool Chromosome Aberrations Clonal Evolution - genetics Core Binding Factors - metabolism Female Gene Expression Regulation, Leukemic High-Throughput Nucleotide Sequencing Humans Infant Leukemia, Myeloid, Acute - etiology Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - pathology Life Sciences Male Middle Aged Mutation Prognosis Retrospective Studies Signal Transduction Survival Analysis Young Adult
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