Alterations of treatment-naïve pelvis and thigh muscle morphology in children with cerebral palsy
Lower limb (LL) muscle morphology and growth are altered in children with cerebral palsy (CP). Muscle alterations differ with age and with severity of motor impairment, classified according to the gross motor classification system (GMFCS). Muscle alterations differ also with orthopedic intervention,...
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| Veröffentlicht in: | Journal of biomechanics 2019-01, Vol.82 (3), p.178-185 |
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| creator | Massaad, Abir Assi, Ayman Bakouny, Ziad Bizdikian, Aren Joe Skalli, Wafa Ghanem, Ismat |
| description | Lower limb (LL) muscle morphology and growth are altered in children with cerebral palsy (CP). Muscle alterations differ with age and with severity of motor impairment, classified according to the gross motor classification system (GMFCS). Muscle alterations differ also with orthopedic intervention, frequently performed at the level of the shank muscles since an early age, such as the gastrocnemius. The aim was to investigate the alterations of treatment-naïve pelvis and thigh muscle lengths and volumes in children with GMFCS levels I and II, of varying ages.
17 children with CP (GMFCS I: N = 9, II: N = 8, age: 11.7 ± 4 years), age-matched to 17 typically developing (TD) children, underwent MRI of the LL. Three-dimensional reconstructions of the muscles were performed bilaterally. Muscle volumes and lengths were calculated in 3D and compared between groups. Linear regression between muscle volumes and age were computed.
Adductor-brevis and gracilis lengths, as well as rectus-femoris volume, were decreased in GMFCS I compared to TD (p |
| doi_str_mv | 10.1016/j.jbiomech.2018.10.022 |
| format | Article |
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17 children with CP (GMFCS I: N = 9, II: N = 8, age: 11.7 ± 4 years), age-matched to 17 typically developing (TD) children, underwent MRI of the LL. Three-dimensional reconstructions of the muscles were performed bilaterally. Muscle volumes and lengths were calculated in 3D and compared between groups. Linear regression between muscle volumes and age were computed.
Adductor-brevis and gracilis lengths, as well as rectus-femoris volume, were decreased in GMFCS I compared to TD (p < 0.05). Almost all the reconstructed muscle volumes and lengths were found to be altered in GMFCS II compared to TD and GMFCS I. All muscle volumes showed significant increase with age in TD and GMFCS I (R2 range: 0.3–0.9, p < 0.05). Rectus-femoris, hamstrings and adductor-longus showed reduced increase in the muscle volume with age in GMFCS II when compared to TD and GMFCS I.
Alterations of treatment-naïve pelvis and thigh muscle volumes and lengths, as well as muscle growth, seem to increase with the severity of motor impairment in ambulant children with CP.</description><identifier>ISSN: 0021-9290</identifier><identifier>EISSN: 1873-2380</identifier><identifier>DOI: 10.1016/j.jbiomech.2018.10.022</identifier><identifier>PMID: 30389259</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>3D reconstruction ; Age ; Botulinum toxin ; Cerebral palsy ; Children ; Demographics ; Impairment ; Knee ; Life Sciences ; Lower limbs ; Magnetic resonance imaging ; Morphology ; Motors ; MRI ; Muscle alterations ; Muscle growth ; Muscles ; Paralysis ; Pelvis ; Statistical analysis ; Thigh ; Treatment-naïve</subject><ispartof>Journal of biomechanics, 2019-01, Vol.82 (3), p.178-185</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Jan 3, 2019</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-d087ab69e1f6e5c61997fb1b41c84ebd1e2e9086c511245dd322c0f53f6d8ed23</citedby><cites>FETCH-LOGICAL-c478t-d087ab69e1f6e5c61997fb1b41c84ebd1e2e9086c511245dd322c0f53f6d8ed23</cites><orcidid>0000-0002-3582-9420 ; 0000-0003-1906-5704</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2160134194?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30389259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02865950$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Massaad, Abir</creatorcontrib><creatorcontrib>Assi, Ayman</creatorcontrib><creatorcontrib>Bakouny, Ziad</creatorcontrib><creatorcontrib>Bizdikian, Aren Joe</creatorcontrib><creatorcontrib>Skalli, Wafa</creatorcontrib><creatorcontrib>Ghanem, Ismat</creatorcontrib><title>Alterations of treatment-naïve pelvis and thigh muscle morphology in children with cerebral palsy</title><title>Journal of biomechanics</title><addtitle>J Biomech</addtitle><description>Lower limb (LL) muscle morphology and growth are altered in children with cerebral palsy (CP). Muscle alterations differ with age and with severity of motor impairment, classified according to the gross motor classification system (GMFCS). Muscle alterations differ also with orthopedic intervention, frequently performed at the level of the shank muscles since an early age, such as the gastrocnemius. The aim was to investigate the alterations of treatment-naïve pelvis and thigh muscle lengths and volumes in children with GMFCS levels I and II, of varying ages.
17 children with CP (GMFCS I: N = 9, II: N = 8, age: 11.7 ± 4 years), age-matched to 17 typically developing (TD) children, underwent MRI of the LL. Three-dimensional reconstructions of the muscles were performed bilaterally. Muscle volumes and lengths were calculated in 3D and compared between groups. Linear regression between muscle volumes and age were computed.
Adductor-brevis and gracilis lengths, as well as rectus-femoris volume, were decreased in GMFCS I compared to TD (p < 0.05). Almost all the reconstructed muscle volumes and lengths were found to be altered in GMFCS II compared to TD and GMFCS I. All muscle volumes showed significant increase with age in TD and GMFCS I (R2 range: 0.3–0.9, p < 0.05). Rectus-femoris, hamstrings and adductor-longus showed reduced increase in the muscle volume with age in GMFCS II when compared to TD and GMFCS I.
Alterations of treatment-naïve pelvis and thigh muscle volumes and lengths, as well as muscle growth, seem to increase with the severity of motor impairment in ambulant children with CP.</description><subject>3D reconstruction</subject><subject>Age</subject><subject>Botulinum toxin</subject><subject>Cerebral palsy</subject><subject>Children</subject><subject>Demographics</subject><subject>Impairment</subject><subject>Knee</subject><subject>Life Sciences</subject><subject>Lower limbs</subject><subject>Magnetic resonance imaging</subject><subject>Morphology</subject><subject>Motors</subject><subject>MRI</subject><subject>Muscle alterations</subject><subject>Muscle growth</subject><subject>Muscles</subject><subject>Paralysis</subject><subject>Pelvis</subject><subject>Statistical analysis</subject><subject>Thigh</subject><subject>Treatment-naïve</subject><issn>0021-9290</issn><issn>1873-2380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU-P1CAYh4nRuOPqV9iQeNFDR6AthZuTjbomk3jRM6HwdktDywh0zHwqP4RfTCazuwcvnt7kl-f9Aw9CN5RsKaH8w7SdehdmMOOWESpKuCWMPUMbKrq6YrUgz9GGEEYrySS5Qq9SmgghXdPJl-iqJrWQrJUb1O98hqizC0vCYcA5gs4zLLla9J_fR8AH8EeXsF4szqO7H_G8JuMBzyEexuDD_Qm7BZvReRthwb9cHrGBCH3UHh-0T6fX6MVQKrx5qNfox-dP32_vqv23L19vd_vKNJ3IlSWi0z2XQAcOreFUym7oad9QIxroLQUGkghuWkpZ01pbM2bI0NYDtwIsq6_R-8vcUXt1iG7W8aSCduput1fnjDDBW9mSIy3suwt7iOHnCimr2SUD3usFwpoUo0y2NZNcFPTtP-gU1riUlxSKE1o3VDaF4hfKxJBShOHpAkrU2Zia1KMxdTZ2zoux0njzMH7tZ7BPbY-KCvDxAkD5u6ODqJJxsBiwLoLJygb3vx1_AbpPqww</recordid><startdate>20190103</startdate><enddate>20190103</enddate><creator>Massaad, Abir</creator><creator>Assi, Ayman</creator><creator>Bakouny, Ziad</creator><creator>Bizdikian, Aren Joe</creator><creator>Skalli, Wafa</creator><creator>Ghanem, Ismat</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><general>Elsevier</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TB</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-3582-9420</orcidid><orcidid>https://orcid.org/0000-0003-1906-5704</orcidid></search><sort><creationdate>20190103</creationdate><title>Alterations of treatment-naïve pelvis and thigh muscle morphology in children with cerebral palsy</title><author>Massaad, Abir ; 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Muscle alterations differ with age and with severity of motor impairment, classified according to the gross motor classification system (GMFCS). Muscle alterations differ also with orthopedic intervention, frequently performed at the level of the shank muscles since an early age, such as the gastrocnemius. The aim was to investigate the alterations of treatment-naïve pelvis and thigh muscle lengths and volumes in children with GMFCS levels I and II, of varying ages.
17 children with CP (GMFCS I: N = 9, II: N = 8, age: 11.7 ± 4 years), age-matched to 17 typically developing (TD) children, underwent MRI of the LL. Three-dimensional reconstructions of the muscles were performed bilaterally. Muscle volumes and lengths were calculated in 3D and compared between groups. Linear regression between muscle volumes and age were computed.
Adductor-brevis and gracilis lengths, as well as rectus-femoris volume, were decreased in GMFCS I compared to TD (p < 0.05). Almost all the reconstructed muscle volumes and lengths were found to be altered in GMFCS II compared to TD and GMFCS I. All muscle volumes showed significant increase with age in TD and GMFCS I (R2 range: 0.3–0.9, p < 0.05). Rectus-femoris, hamstrings and adductor-longus showed reduced increase in the muscle volume with age in GMFCS II when compared to TD and GMFCS I.
Alterations of treatment-naïve pelvis and thigh muscle volumes and lengths, as well as muscle growth, seem to increase with the severity of motor impairment in ambulant children with CP.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>30389259</pmid><doi>10.1016/j.jbiomech.2018.10.022</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3582-9420</orcidid><orcidid>https://orcid.org/0000-0003-1906-5704</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 3D reconstruction Age Botulinum toxin Cerebral palsy Children Demographics Impairment Knee Life Sciences Lower limbs Magnetic resonance imaging Morphology Motors MRI Muscle alterations Muscle growth Muscles Paralysis Pelvis Statistical analysis Thigh Treatment-naïve |
| title | Alterations of treatment-naïve pelvis and thigh muscle morphology in children with cerebral palsy |
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