Effects of chemical pollution on the activities of hepatic xenobiotic metabolizing enzymes in fish from the river rhône
Polychlorobiphenyl (PCBs) levels and hepatic xenobiotic metabolizing enzyme activities were measured in fish from three locations of the River Rhône to study the consequences of a constant loading of PCBs from a PCB incineration plant. Our results show that levels of PCBs and enzyme activities were...
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Veröffentlicht in: | The Science of the total environment 1988-07, Vol.73 (3), p.189-201 |
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description | Polychlorobiphenyl (PCBs) levels and hepatic xenobiotic metabolizing enzyme activities were measured in fish from three locations of the River Rhône to study the consequences of a constant loading of PCBs from a PCB incineration plant. Our results show that levels of PCBs and enzyme activities were higher in fish living downstream from the plant than in fish from two locations upstream, suggesting enzyme induction by PCBs (known to be potent inducers in laboratory conditions). Enzyme activities were studied in spring and autumn in three species: nase (
Chondrostoma nasus), roach (
Rutilus rutilus) and grayling (
Thymallus thymallus). Induction was observed for three cytochrome P-450-dependent monooxygenase activities (MO), i.e. 7-ethoxyresorufin
O-deethylase (EROD), aryl hydrocarbon hydroxylase (AHH) and 7-ethoxycoumarin
O-deethylase (ECOD). There was a close correlation between EROD and AHH activities (for all species). Glutathione
S-transferase activities were also shown to be related to the PCB levels. Conversely, cytochrome P-450 content and benzphetamine
N-demethylase activity were not “PCB level-dependent”. This study clearly demonstrates a close relationship between PCB contamination and MO activities in fish from the field and thus clearly emphasizes the interest in MO as a monitoring tool for estimating water quality. |
doi_str_mv | 10.1016/0048-9697(88)90428-7 |
format | Article |
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Chondrostoma nasus), roach (
Rutilus rutilus) and grayling (
Thymallus thymallus). Induction was observed for three cytochrome P-450-dependent monooxygenase activities (MO), i.e. 7-ethoxyresorufin
O-deethylase (EROD), aryl hydrocarbon hydroxylase (AHH) and 7-ethoxycoumarin
O-deethylase (ECOD). There was a close correlation between EROD and AHH activities (for all species). Glutathione
S-transferase activities were also shown to be related to the PCB levels. Conversely, cytochrome P-450 content and benzphetamine
N-demethylase activity were not “PCB level-dependent”. This study clearly demonstrates a close relationship between PCB contamination and MO activities in fish from the field and thus clearly emphasizes the interest in MO as a monitoring tool for estimating water quality.</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/0048-9697(88)90428-7</identifier><identifier>PMID: 3145559</identifier><identifier>CODEN: STENDL</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>7-Alkoxycoumarin O-Dealkylase ; Animals ; Benzopyrene Hydroxylase - metabolism ; Biological and medical sciences ; Cytochrome P-450 CYP1A1 ; Cytochrome P-450 Enzyme System - metabolism ; Environmental pollutants toxicology ; Fishes - metabolism ; France ; Fresh Water ; Geography ; Glutathione Transferase - metabolism ; Life Sciences ; Male ; Medical sciences ; Microsomes, Liver - enzymology ; NADPH-Ferrihemoprotein Reductase - metabolism ; Oxidoreductases - metabolism ; Oxidoreductases, N-Demethylating - metabolism ; Oxygenases - metabolism ; Polychlorinated Biphenyls - analysis ; Toxicology ; Water ; Water Pollutants - analysis ; Water Pollutants, Chemical - analysis</subject><ispartof>The Science of the total environment, 1988-07, Vol.73 (3), p.189-201</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-431511a2fc50311428ccaad74fd7828cb4c7316444759745c40f23c75e78a3d03</citedby><cites>FETCH-LOGICAL-c497t-431511a2fc50311428ccaad74fd7828cb4c7316444759745c40f23c75e78a3d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0048-9697(88)90428-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7112181$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3145559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02728064$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Monod, G.</creatorcontrib><creatorcontrib>Devaux, A.</creatorcontrib><creatorcontrib>Riviere, J.L.</creatorcontrib><title>Effects of chemical pollution on the activities of hepatic xenobiotic metabolizing enzymes in fish from the river rhône</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>Polychlorobiphenyl (PCBs) levels and hepatic xenobiotic metabolizing enzyme activities were measured in fish from three locations of the River Rhône to study the consequences of a constant loading of PCBs from a PCB incineration plant. Our results show that levels of PCBs and enzyme activities were higher in fish living downstream from the plant than in fish from two locations upstream, suggesting enzyme induction by PCBs (known to be potent inducers in laboratory conditions). Enzyme activities were studied in spring and autumn in three species: nase (
Chondrostoma nasus), roach (
Rutilus rutilus) and grayling (
Thymallus thymallus). Induction was observed for three cytochrome P-450-dependent monooxygenase activities (MO), i.e. 7-ethoxyresorufin
O-deethylase (EROD), aryl hydrocarbon hydroxylase (AHH) and 7-ethoxycoumarin
O-deethylase (ECOD). There was a close correlation between EROD and AHH activities (for all species). Glutathione
S-transferase activities were also shown to be related to the PCB levels. Conversely, cytochrome P-450 content and benzphetamine
N-demethylase activity were not “PCB level-dependent”. This study clearly demonstrates a close relationship between PCB contamination and MO activities in fish from the field and thus clearly emphasizes the interest in MO as a monitoring tool for estimating water quality.</description><subject>7-Alkoxycoumarin O-Dealkylase</subject><subject>Animals</subject><subject>Benzopyrene Hydroxylase - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cytochrome P-450 CYP1A1</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>Environmental pollutants toxicology</subject><subject>Fishes - metabolism</subject><subject>France</subject><subject>Fresh Water</subject><subject>Geography</subject><subject>Glutathione Transferase - metabolism</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microsomes, Liver - enzymology</subject><subject>NADPH-Ferrihemoprotein Reductase - metabolism</subject><subject>Oxidoreductases - metabolism</subject><subject>Oxidoreductases, N-Demethylating - metabolism</subject><subject>Oxygenases - metabolism</subject><subject>Polychlorinated Biphenyls - analysis</subject><subject>Toxicology</subject><subject>Water</subject><subject>Water Pollutants - analysis</subject><subject>Water Pollutants, Chemical - analysis</subject><issn>0048-9697</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2OFCEQx4nRrOPqG2jCwRj30ArddENfTDab_TCZxIueCUMXdpluGIGZ7O5z-Qa-mPTOZI5WSAqoX1VB_Ql5y9knznj3mTGhqr7r5UelLnomalXJZ2TFlewrzuruOVmdkJfkVUq_WDGp-Bk5a7ho27Zfkftr58DmRIOjdoQZrZnoNkzTLmPwtKw8AjU24x4zwhM3wtZktPQefNhgWLYzZLMJEz6i_0nBPz7MBUVPHaaRuhjmpzIR9xBpHP_-8fCavHBmSvDm6M_Jj5vr71d31frb7dery3VlRS9zJRrecm5qZ1vWcF4-aa0xgxRukKocNsLKhndCCNn2UrRWMFc3VrYglWkG1pyTi0Pd0Ux6G3E28UEHg_rucq2XO1bLWrFO7HlhPxzYbQy_d5CynjFZmCbjIeyS5o0sxhdQHEAbQ0oR3KkyZ3oRRy-T18vktSp-EUfLkvbuWH-3mWE4JR3VKPH3x7hJRQcXjbeYTljpXHO1dP9ywKDMbY8QdbII3sKAsWiph4D_f8c_Fa6rjw</recordid><startdate>19880715</startdate><enddate>19880715</enddate><creator>Monod, G.</creator><creator>Devaux, A.</creator><creator>Riviere, J.L.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>1XC</scope><scope>VOOES</scope></search><sort><creationdate>19880715</creationdate><title>Effects of chemical pollution on the activities of hepatic xenobiotic metabolizing enzymes in fish from the river rhône</title><author>Monod, G. ; Devaux, A. ; Riviere, J.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-431511a2fc50311428ccaad74fd7828cb4c7316444759745c40f23c75e78a3d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>7-Alkoxycoumarin O-Dealkylase</topic><topic>Animals</topic><topic>Benzopyrene Hydroxylase - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cytochrome P-450 CYP1A1</topic><topic>Cytochrome P-450 Enzyme System - metabolism</topic><topic>Environmental pollutants toxicology</topic><topic>Fishes - metabolism</topic><topic>France</topic><topic>Fresh Water</topic><topic>Geography</topic><topic>Glutathione Transferase - metabolism</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microsomes, Liver - enzymology</topic><topic>NADPH-Ferrihemoprotein Reductase - metabolism</topic><topic>Oxidoreductases - metabolism</topic><topic>Oxidoreductases, N-Demethylating - metabolism</topic><topic>Oxygenases - metabolism</topic><topic>Polychlorinated Biphenyls - analysis</topic><topic>Toxicology</topic><topic>Water</topic><topic>Water Pollutants - analysis</topic><topic>Water Pollutants, Chemical - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Monod, G.</creatorcontrib><creatorcontrib>Devaux, A.</creatorcontrib><creatorcontrib>Riviere, J.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>The Science of the total environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Monod, G.</au><au>Devaux, A.</au><au>Riviere, J.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of chemical pollution on the activities of hepatic xenobiotic metabolizing enzymes in fish from the river rhône</atitle><jtitle>The Science of the total environment</jtitle><addtitle>Sci Total Environ</addtitle><date>1988-07-15</date><risdate>1988</risdate><volume>73</volume><issue>3</issue><spage>189</spage><epage>201</epage><pages>189-201</pages><issn>0048-9697</issn><eissn>1879-1026</eissn><coden>STENDL</coden><abstract>Polychlorobiphenyl (PCBs) levels and hepatic xenobiotic metabolizing enzyme activities were measured in fish from three locations of the River Rhône to study the consequences of a constant loading of PCBs from a PCB incineration plant. Our results show that levels of PCBs and enzyme activities were higher in fish living downstream from the plant than in fish from two locations upstream, suggesting enzyme induction by PCBs (known to be potent inducers in laboratory conditions). Enzyme activities were studied in spring and autumn in three species: nase (
Chondrostoma nasus), roach (
Rutilus rutilus) and grayling (
Thymallus thymallus). Induction was observed for three cytochrome P-450-dependent monooxygenase activities (MO), i.e. 7-ethoxyresorufin
O-deethylase (EROD), aryl hydrocarbon hydroxylase (AHH) and 7-ethoxycoumarin
O-deethylase (ECOD). There was a close correlation between EROD and AHH activities (for all species). Glutathione
S-transferase activities were also shown to be related to the PCB levels. Conversely, cytochrome P-450 content and benzphetamine
N-demethylase activity were not “PCB level-dependent”. This study clearly demonstrates a close relationship between PCB contamination and MO activities in fish from the field and thus clearly emphasizes the interest in MO as a monitoring tool for estimating water quality.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>3145559</pmid><doi>10.1016/0048-9697(88)90428-7</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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subjects | 7-Alkoxycoumarin O-Dealkylase Animals Benzopyrene Hydroxylase - metabolism Biological and medical sciences Cytochrome P-450 CYP1A1 Cytochrome P-450 Enzyme System - metabolism Environmental pollutants toxicology Fishes - metabolism France Fresh Water Geography Glutathione Transferase - metabolism Life Sciences Male Medical sciences Microsomes, Liver - enzymology NADPH-Ferrihemoprotein Reductase - metabolism Oxidoreductases - metabolism Oxidoreductases, N-Demethylating - metabolism Oxygenases - metabolism Polychlorinated Biphenyls - analysis Toxicology Water Water Pollutants - analysis Water Pollutants, Chemical - analysis |
title | Effects of chemical pollution on the activities of hepatic xenobiotic metabolizing enzymes in fish from the river rhône |
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