Effects of Lindane Exposure on Rainbow Trout (Oncorhynchus mykiss) Immunity: III. Effect on Nonspecific Immunity and B Lymphocyte Functions
The effect of the organochlorine insecticide lindane (γ-hexachlorocyclohexane) was examined on some major immune functions of rainbow trout (Oncorhynchus mykiss) on the chemiluminescent response of pronephric cells (PMA-induced) in phagocytosis, on the proliferation of lymphocytes with B and T mitog...
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| Veröffentlicht in: | Ecotoxicology and environmental safety 1994-04, Vol.27 (3), p.324-334 |
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| creator | Dunier, M. Siwicki, A.K. Scholtens, J. Molin, S.D. Vergnet, C. Studnicka, M. |
| description | The effect of the organochlorine insecticide lindane (γ-hexachlorocyclohexane) was examined on some major immune functions of rainbow trout (Oncorhynchus mykiss) on the chemiluminescent response of pronephric cells (PMA-induced) in phagocytosis, on the proliferation of lymphocytes with B and T mitogens, and on the number of B lymphocytes analyzed by cytofluorometry. Two different methods of exposure were tried via food (first protocol) and via a single intraperitoneal injection (second protocol). After the oral contamination at a daily body dose of 1 mg/kg for 30 days, a decreased chemiluminescent response was observed which persisted for two more weeks and disappeared over 1.5 months. No effect was observed on lymphocyte proliferation and on the number of circulating B lymphocytes. In the second protocol lindane was administered intraperitoneally at 10, 50, or 100 mg/kg body wt. After 45 days the lymphocyte proliferation of B cells was depressed but not the T cell one. The B cells number in head kidney as measured by cytofluorometry was not significantly modified. Some nonspecific immunity parameters in sera were significantly modified. |
| doi_str_mv | 10.1006/eesa.1994.1026 |
| format | Article |
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Effect on Nonspecific Immunity and B Lymphocyte Functions</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Dunier, M. ; Siwicki, A.K. ; Scholtens, J. ; Molin, S.D. ; Vergnet, C. ; Studnicka, M.</creator><creatorcontrib>Dunier, M. ; Siwicki, A.K. ; Scholtens, J. ; Molin, S.D. ; Vergnet, C. ; Studnicka, M.</creatorcontrib><description>The effect of the organochlorine insecticide lindane (γ-hexachlorocyclohexane) was examined on some major immune functions of rainbow trout (Oncorhynchus mykiss) on the chemiluminescent response of pronephric cells (PMA-induced) in phagocytosis, on the proliferation of lymphocytes with B and T mitogens, and on the number of B lymphocytes analyzed by cytofluorometry. Two different methods of exposure were tried via food (first protocol) and via a single intraperitoneal injection (second protocol). After the oral contamination at a daily body dose of 1 mg/kg for 30 days, a decreased chemiluminescent response was observed which persisted for two more weeks and disappeared over 1.5 months. No effect was observed on lymphocyte proliferation and on the number of circulating B lymphocytes. In the second protocol lindane was administered intraperitoneally at 10, 50, or 100 mg/kg body wt. After 45 days the lymphocyte proliferation of B cells was depressed but not the T cell one. The B cells number in head kidney as measured by cytofluorometry was not significantly modified. Some nonspecific immunity parameters in sera were significantly modified.</description><identifier>ISSN: 0147-6513</identifier><identifier>EISSN: 1090-2414</identifier><identifier>DOI: 10.1006/eesa.1994.1026</identifier><identifier>PMID: 7519551</identifier><identifier>CODEN: EESADV</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Administration, Oral ; Agnatha. Pisces ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; B-Lymphocytes - drug effects ; B-Lymphocytes - immunology ; Biological and medical sciences ; Cell Division - drug effects ; Ceruloplasmin - immunology ; Ceruloplasmin - metabolism ; Dose-Response Relationship, Drug ; Drug Residues - analysis ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on vertebrates ; Fundamental and applied biological sciences. Psychology ; Injections, Intraperitoneal ; Kidney - drug effects ; Kidney - immunology ; Life Sciences ; Lindane - administration & dosage ; Lindane - pharmacokinetics ; Lindane - toxicity ; Lymphocyte Activation - drug effects ; Muramidase - blood ; Muramidase - immunology ; Neutrophils - drug effects ; Oncorhynchus mykiss - immunology ; Phagocytosis - drug effects</subject><ispartof>Ecotoxicology and environmental safety, 1994-04, Vol.27 (3), p.324-334</ispartof><rights>1994 Academic Press</rights><rights>1994 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/eesa.1994.1026$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4114853$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7519551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02715039$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Dunier, M.</creatorcontrib><creatorcontrib>Siwicki, A.K.</creatorcontrib><creatorcontrib>Scholtens, J.</creatorcontrib><creatorcontrib>Molin, S.D.</creatorcontrib><creatorcontrib>Vergnet, C.</creatorcontrib><creatorcontrib>Studnicka, M.</creatorcontrib><title>Effects of Lindane Exposure on Rainbow Trout (Oncorhynchus mykiss) Immunity: III. Effect on Nonspecific Immunity and B Lymphocyte Functions</title><title>Ecotoxicology and environmental safety</title><addtitle>Ecotoxicol Environ Saf</addtitle><description>The effect of the organochlorine insecticide lindane (γ-hexachlorocyclohexane) was examined on some major immune functions of rainbow trout (Oncorhynchus mykiss) on the chemiluminescent response of pronephric cells (PMA-induced) in phagocytosis, on the proliferation of lymphocytes with B and T mitogens, and on the number of B lymphocytes analyzed by cytofluorometry. Two different methods of exposure were tried via food (first protocol) and via a single intraperitoneal injection (second protocol). After the oral contamination at a daily body dose of 1 mg/kg for 30 days, a decreased chemiluminescent response was observed which persisted for two more weeks and disappeared over 1.5 months. No effect was observed on lymphocyte proliferation and on the number of circulating B lymphocytes. In the second protocol lindane was administered intraperitoneally at 10, 50, or 100 mg/kg body wt. After 45 days the lymphocyte proliferation of B cells was depressed but not the T cell one. The B cells number in head kidney as measured by cytofluorometry was not significantly modified. Some nonspecific immunity parameters in sera were significantly modified.</description><subject>Administration, Oral</subject><subject>Agnatha. Pisces</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>B-Lymphocytes - drug effects</subject><subject>B-Lymphocytes - immunology</subject><subject>Biological and medical sciences</subject><subject>Cell Division - drug effects</subject><subject>Ceruloplasmin - immunology</subject><subject>Ceruloplasmin - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Residues - analysis</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Intraperitoneal</subject><subject>Kidney - drug effects</subject><subject>Kidney - immunology</subject><subject>Life Sciences</subject><subject>Lindane - administration & dosage</subject><subject>Lindane - pharmacokinetics</subject><subject>Lindane - toxicity</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Muramidase - blood</subject><subject>Muramidase - immunology</subject><subject>Neutrophils - drug effects</subject><subject>Oncorhynchus mykiss - immunology</subject><subject>Phagocytosis - drug effects</subject><issn>0147-6513</issn><issn>1090-2414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkFv1DAUhC0EKkvhyg3JB4ToIYtfbCd2b6Xa0kgRlVA5W17b0RoSO8RJIb-BP02iXe2Vk_U83xtZ40HoLZAtEFJ8ci7pLUjJljEvnqENEEmynAF7jjYEWJkVHOhL9CqlH4QQSji_QBclB8k5bNDfXdM4MyYcG1z7YHVwePenj2kaHI4Bf9M-7ONv_DjEacQfH4KJw2EO5jAl3M0_fUpXuOq6KfhxvsZVVW3x0XFd_hpD6p3xjTdnCOtg8Wdcz11_iGYeHb6bghn9gr5GLxrdJvfmdF6i73e7x9v7rH74Ut3e1JnLJR-zxhhpLKGclUIz0Yi9k5yIptAlNaUuHLVFLixnuYFCg-HWAmgmF4kVphT0El0dfQ-6Vf3gOz3MKmqv7m9qtd6RvAROqHyChf1wZPsh_ppcGlXnk3FtuwQVp6SAUSqYFP8HaVFyIVbHdydw2nfOnh9w-pJFf3_SdTK6bQYdjE9njAEwwemCiSPmlqSevBtUMt4F46wflviVjV4BUWtH1NoRtXZErR2h_wDSMa10</recordid><startdate>199404</startdate><enddate>199404</enddate><creator>Dunier, M.</creator><creator>Siwicki, A.K.</creator><creator>Scholtens, J.</creator><creator>Molin, S.D.</creator><creator>Vergnet, C.</creator><creator>Studnicka, M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QH</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>1XC</scope></search><sort><creationdate>199404</creationdate><title>Effects of Lindane Exposure on Rainbow Trout (Oncorhynchus mykiss) Immunity: III. Effect on Nonspecific Immunity and B Lymphocyte Functions</title><author>Dunier, M. ; Siwicki, A.K. ; Scholtens, J. ; Molin, S.D. ; Vergnet, C. ; Studnicka, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e295t-fcc9cd035478a48f8be9508f6a73c7a6e3d628d542c16a1c5dd11a497a646c783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Administration, Oral</topic><topic>Agnatha. Pisces</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>B-Lymphocytes - drug effects</topic><topic>B-Lymphocytes - immunology</topic><topic>Biological and medical sciences</topic><topic>Cell Division - drug effects</topic><topic>Ceruloplasmin - immunology</topic><topic>Ceruloplasmin - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Residues - analysis</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Intraperitoneal</topic><topic>Kidney - drug effects</topic><topic>Kidney - immunology</topic><topic>Life Sciences</topic><topic>Lindane - administration & dosage</topic><topic>Lindane - pharmacokinetics</topic><topic>Lindane - toxicity</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Muramidase - blood</topic><topic>Muramidase - immunology</topic><topic>Neutrophils - drug effects</topic><topic>Oncorhynchus mykiss - immunology</topic><topic>Phagocytosis - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dunier, M.</creatorcontrib><creatorcontrib>Siwicki, A.K.</creatorcontrib><creatorcontrib>Scholtens, J.</creatorcontrib><creatorcontrib>Molin, S.D.</creatorcontrib><creatorcontrib>Vergnet, C.</creatorcontrib><creatorcontrib>Studnicka, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Aqualine</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Ecotoxicology and environmental safety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dunier, M.</au><au>Siwicki, A.K.</au><au>Scholtens, J.</au><au>Molin, S.D.</au><au>Vergnet, C.</au><au>Studnicka, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Lindane Exposure on Rainbow Trout (Oncorhynchus mykiss) Immunity: III. Effect on Nonspecific Immunity and B Lymphocyte Functions</atitle><jtitle>Ecotoxicology and environmental safety</jtitle><addtitle>Ecotoxicol Environ Saf</addtitle><date>1994-04</date><risdate>1994</risdate><volume>27</volume><issue>3</issue><spage>324</spage><epage>334</epage><pages>324-334</pages><issn>0147-6513</issn><eissn>1090-2414</eissn><coden>EESADV</coden><abstract>The effect of the organochlorine insecticide lindane (γ-hexachlorocyclohexane) was examined on some major immune functions of rainbow trout (Oncorhynchus mykiss) on the chemiluminescent response of pronephric cells (PMA-induced) in phagocytosis, on the proliferation of lymphocytes with B and T mitogens, and on the number of B lymphocytes analyzed by cytofluorometry. Two different methods of exposure were tried via food (first protocol) and via a single intraperitoneal injection (second protocol). After the oral contamination at a daily body dose of 1 mg/kg for 30 days, a decreased chemiluminescent response was observed which persisted for two more weeks and disappeared over 1.5 months. No effect was observed on lymphocyte proliferation and on the number of circulating B lymphocytes. In the second protocol lindane was administered intraperitoneally at 10, 50, or 100 mg/kg body wt. After 45 days the lymphocyte proliferation of B cells was depressed but not the T cell one. The B cells number in head kidney as measured by cytofluorometry was not significantly modified. Some nonspecific immunity parameters in sera were significantly modified.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>7519551</pmid><doi>10.1006/eesa.1994.1026</doi><tpages>11</tpages></addata></record> |
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| ispartof | Ecotoxicology and environmental safety, 1994-04, Vol.27 (3), p.324-334 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Administration, Oral Agnatha. Pisces Animal, plant and microbial ecology Animals Applied ecology B-Lymphocytes - drug effects B-Lymphocytes - immunology Biological and medical sciences Cell Division - drug effects Ceruloplasmin - immunology Ceruloplasmin - metabolism Dose-Response Relationship, Drug Drug Residues - analysis Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Fundamental and applied biological sciences. Psychology Injections, Intraperitoneal Kidney - drug effects Kidney - immunology Life Sciences Lindane - administration & dosage Lindane - pharmacokinetics Lindane - toxicity Lymphocyte Activation - drug effects Muramidase - blood Muramidase - immunology Neutrophils - drug effects Oncorhynchus mykiss - immunology Phagocytosis - drug effects |
| title | Effects of Lindane Exposure on Rainbow Trout (Oncorhynchus mykiss) Immunity: III. Effect on Nonspecific Immunity and B Lymphocyte Functions |
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