Inhibitory effect of human syncytiotrophoblast plasma membrane vesicles on Jurkat cells activated by phorbol ester and calcium ionophore
The effects of syncytiotrophoblast plasma membrane vesicles (STPM) on stimulated Jurkat leukemic T cells have been investigated. STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore...
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| Veröffentlicht in: | Cellular immunology 1992, Vol.139 (1), p.259-267 |
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| creator | THIBAULT, G DEGENNE, D LACORD, M GUILLAUMIN, J. M GIRARD, A. C BARDOS, P |
| description | The effects of syncytiotrophoblast plasma membrane vesicles (STPM) on stimulated Jurkat leukemic T cells have been investigated. STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA). STPM also inhibited IL-2R P55 when cells were stimulated by PMA alone, a situation in which IL-2 production is negligible. On the other hand, STPM had no effect on the sustained mobilization of intracellular Ca2+ induced by CaI nor on the PKC-dependent CD3 down regulation induced by PMA. Finally STPM had no effect on intracellular cAMP levels. These results show that (i) the inhibitory effect of STPM on IL-2R P55 expression is independent of the inhibition of IL-2 production, and (ii) the inhibitory effects of STPM are at least partially independent of phosphatidylinositol 4,5-bisphosphate hydrolysis. They suggest that STPM affect a signaling pathway activated by PMA but possibly PKC independent. |
| doi_str_mv | 10.1016/0008-8749(92)90118-9 |
| format | Article |
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M ; GIRARD, A. C ; BARDOS, P</creator><creatorcontrib>THIBAULT, G ; DEGENNE, D ; LACORD, M ; GUILLAUMIN, J. M ; GIRARD, A. C ; BARDOS, P</creatorcontrib><description>The effects of syncytiotrophoblast plasma membrane vesicles (STPM) on stimulated Jurkat leukemic T cells have been investigated. STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA). STPM also inhibited IL-2R P55 when cells were stimulated by PMA alone, a situation in which IL-2 production is negligible. On the other hand, STPM had no effect on the sustained mobilization of intracellular Ca2+ induced by CaI nor on the PKC-dependent CD3 down regulation induced by PMA. Finally STPM had no effect on intracellular cAMP levels. These results show that (i) the inhibitory effect of STPM on IL-2R P55 expression is independent of the inhibition of IL-2 production, and (ii) the inhibitory effects of STPM are at least partially independent of phosphatidylinositol 4,5-bisphosphate hydrolysis. They suggest that STPM affect a signaling pathway activated by PMA but possibly PKC independent.</description><identifier>ISSN: 0008-8749</identifier><identifier>EISSN: 1090-2163</identifier><identifier>DOI: 10.1016/0008-8749(92)90118-9</identifier><identifier>PMID: 1309491</identifier><identifier>CODEN: CLIMB8</identifier><language>eng</language><publisher>San Diego, CA: Elsevier</publisher><subject>Antigens, Differentiation, T-Lymphocyte - metabolism ; Biological and medical sciences ; Calcimycin - pharmacology ; Calcium - physiology ; CD3 Complex ; Cell Membrane - immunology ; Colforsin - pharmacology ; Cyclic AMP - physiology ; Cytoplasm - metabolism ; Down-Regulation ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immunobiology ; Interleukin-2 - biosynthesis ; Life Sciences ; Lymphocyte Activation - drug effects ; Modulation of the immune response (stimulation, suppression) ; Other ; Pregnancy - immunology ; Protein Kinase C - metabolism ; Receptors, Antigen, T-Cell - metabolism ; Receptors, Interleukin-2 - metabolism ; T-Lymphocytes - immunology ; Tetradecanoylphorbol Acetate - pharmacology ; Trophoblasts - immunology ; Tumor Cells, Cultured</subject><ispartof>Cellular immunology, 1992, Vol.139 (1), p.259-267</ispartof><rights>1992 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-2666-4839 ; 0000-0002-7614-8103</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5552633$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1309491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02714903$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>THIBAULT, G</creatorcontrib><creatorcontrib>DEGENNE, D</creatorcontrib><creatorcontrib>LACORD, M</creatorcontrib><creatorcontrib>GUILLAUMIN, J. M</creatorcontrib><creatorcontrib>GIRARD, A. C</creatorcontrib><creatorcontrib>BARDOS, P</creatorcontrib><title>Inhibitory effect of human syncytiotrophoblast plasma membrane vesicles on Jurkat cells activated by phorbol ester and calcium ionophore</title><title>Cellular immunology</title><addtitle>Cell Immunol</addtitle><description>The effects of syncytiotrophoblast plasma membrane vesicles (STPM) on stimulated Jurkat leukemic T cells have been investigated. STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA). STPM also inhibited IL-2R P55 when cells were stimulated by PMA alone, a situation in which IL-2 production is negligible. On the other hand, STPM had no effect on the sustained mobilization of intracellular Ca2+ induced by CaI nor on the PKC-dependent CD3 down regulation induced by PMA. Finally STPM had no effect on intracellular cAMP levels. These results show that (i) the inhibitory effect of STPM on IL-2R P55 expression is independent of the inhibition of IL-2 production, and (ii) the inhibitory effects of STPM are at least partially independent of phosphatidylinositol 4,5-bisphosphate hydrolysis. They suggest that STPM affect a signaling pathway activated by PMA but possibly PKC independent.</description><subject>Antigens, Differentiation, T-Lymphocyte - metabolism</subject><subject>Biological and medical sciences</subject><subject>Calcimycin - pharmacology</subject><subject>Calcium - physiology</subject><subject>CD3 Complex</subject><subject>Cell Membrane - immunology</subject><subject>Colforsin - pharmacology</subject><subject>Cyclic AMP - physiology</subject><subject>Cytoplasm - metabolism</subject><subject>Down-Regulation</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Interleukin-2 - biosynthesis</subject><subject>Life Sciences</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Modulation of the immune response (stimulation, suppression)</subject><subject>Other</subject><subject>Pregnancy - immunology</subject><subject>Protein Kinase C - metabolism</subject><subject>Receptors, Antigen, T-Cell - metabolism</subject><subject>Receptors, Interleukin-2 - metabolism</subject><subject>T-Lymphocytes - immunology</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><subject>Trophoblasts - immunology</subject><subject>Tumor Cells, Cultured</subject><issn>0008-8749</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1q3EAQhIfgYK-dvEEMffAhPsiZX63maEziHxZySc5Lz6iFJpE0y8zsgt4gjx0tXvbSDV1fF1Qx9kXwB8FF_Y1z3lTNWtuvVt5bLkRT2Q9sJbjllRS1umCrM3LFrnP-wxdIW37JLoXiVluxYv9epz64UGKagbqOfIHYQb8fcYI8T34uIZYUd310A-YCu2WOCCONLuFEcKAc_EAZ4gRv-_QXC3gahgzoSzhgoRbcDMt7cnEAyoUS4NSCx8GH_QghTkfzRJ_Yxw6HTJ9P-4b9_vH919NLtfn5_Pr0uKl6yUWpfEdSeU3St2hJt9hYo7Ujh1wLJyVaZU2H0nCnTFOvnela04hWaO1roWp1w-7ffXsctrsURkzzNmLYvjxutscbl-tjSeogFvb2nd3t3UjtGT-1t-h3Jx3zEqhbGvEhnzFjjKyVUv8BP1aBdg</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>THIBAULT, G</creator><creator>DEGENNE, D</creator><creator>LACORD, M</creator><creator>GUILLAUMIN, J. M</creator><creator>GIRARD, A. C</creator><creator>BARDOS, P</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-2666-4839</orcidid><orcidid>https://orcid.org/0000-0002-7614-8103</orcidid></search><sort><creationdate>1992</creationdate><title>Inhibitory effect of human syncytiotrophoblast plasma membrane vesicles on Jurkat cells activated by phorbol ester and calcium ionophore</title><author>THIBAULT, G ; DEGENNE, D ; LACORD, M ; GUILLAUMIN, J. M ; GIRARD, A. C ; BARDOS, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h201t-cfe23c4e2cda9e4da89544beba041b22a9395fa250b35867b5fd581d144c61363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Antigens, Differentiation, T-Lymphocyte - metabolism</topic><topic>Biological and medical sciences</topic><topic>Calcimycin - pharmacology</topic><topic>Calcium - physiology</topic><topic>CD3 Complex</topic><topic>Cell Membrane - immunology</topic><topic>Colforsin - pharmacology</topic><topic>Cyclic AMP - physiology</topic><topic>Cytoplasm - metabolism</topic><topic>Down-Regulation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Interleukin-2 - biosynthesis</topic><topic>Life Sciences</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Modulation of the immune response (stimulation, suppression)</topic><topic>Other</topic><topic>Pregnancy - immunology</topic><topic>Protein Kinase C - metabolism</topic><topic>Receptors, Antigen, T-Cell - metabolism</topic><topic>Receptors, Interleukin-2 - metabolism</topic><topic>T-Lymphocytes - immunology</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><topic>Trophoblasts - immunology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THIBAULT, G</creatorcontrib><creatorcontrib>DEGENNE, D</creatorcontrib><creatorcontrib>LACORD, M</creatorcontrib><creatorcontrib>GUILLAUMIN, J. M</creatorcontrib><creatorcontrib>GIRARD, A. C</creatorcontrib><creatorcontrib>BARDOS, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>THIBAULT, G</au><au>DEGENNE, D</au><au>LACORD, M</au><au>GUILLAUMIN, J. M</au><au>GIRARD, A. C</au><au>BARDOS, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory effect of human syncytiotrophoblast plasma membrane vesicles on Jurkat cells activated by phorbol ester and calcium ionophore</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>1992</date><risdate>1992</risdate><volume>139</volume><issue>1</issue><spage>259</spage><epage>267</epage><pages>259-267</pages><issn>0008-8749</issn><eissn>1090-2163</eissn><coden>CLIMB8</coden><abstract>The effects of syncytiotrophoblast plasma membrane vesicles (STPM) on stimulated Jurkat leukemic T cells have been investigated. STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA). STPM also inhibited IL-2R P55 when cells were stimulated by PMA alone, a situation in which IL-2 production is negligible. On the other hand, STPM had no effect on the sustained mobilization of intracellular Ca2+ induced by CaI nor on the PKC-dependent CD3 down regulation induced by PMA. Finally STPM had no effect on intracellular cAMP levels. These results show that (i) the inhibitory effect of STPM on IL-2R P55 expression is independent of the inhibition of IL-2 production, and (ii) the inhibitory effects of STPM are at least partially independent of phosphatidylinositol 4,5-bisphosphate hydrolysis. They suggest that STPM affect a signaling pathway activated by PMA but possibly PKC independent.</abstract><cop>San Diego, CA</cop><pub>Elsevier</pub><pmid>1309491</pmid><doi>10.1016/0008-8749(92)90118-9</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2666-4839</orcidid><orcidid>https://orcid.org/0000-0002-7614-8103</orcidid></addata></record> |
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| ispartof | Cellular immunology, 1992, Vol.139 (1), p.259-267 |
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| subjects | Antigens, Differentiation, T-Lymphocyte - metabolism Biological and medical sciences Calcimycin - pharmacology Calcium - physiology CD3 Complex Cell Membrane - immunology Colforsin - pharmacology Cyclic AMP - physiology Cytoplasm - metabolism Down-Regulation Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Interleukin-2 - biosynthesis Life Sciences Lymphocyte Activation - drug effects Modulation of the immune response (stimulation, suppression) Other Pregnancy - immunology Protein Kinase C - metabolism Receptors, Antigen, T-Cell - metabolism Receptors, Interleukin-2 - metabolism T-Lymphocytes - immunology Tetradecanoylphorbol Acetate - pharmacology Trophoblasts - immunology Tumor Cells, Cultured |
| title | Inhibitory effect of human syncytiotrophoblast plasma membrane vesicles on Jurkat cells activated by phorbol ester and calcium ionophore |
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