Fasciola hepatica: Mebendazole and Thiabendazole Pharmacokinetics in Sheep

Pharmacokinetics of the two anthelmintic drugs mebendazole and thiabendazole were determined in sheep before and 4, 8, 13, 19, and 25 weeks after an infestation of animals by an oral administration of 150 metacercariae of Fasciola hepatica. The parasitic pathology was ascertained by the increase in...

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Veröffentlicht in:	Experimental parasitology 1994-09, Vol.79 (2), p.166-176
Hauptverfasser:	Galtier, P., Coulet, M., Sutra, J.F., Birosauveur, B., Alvinerie, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTIVIDAD ENZIMATICA ACTIVITE ENZYMATIQUE Administration, Oral Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents APPLICATION METHODS BENZIMIDAZOLE BENZIMIDAZOLES Biological and medical sciences BLOOD PLASMA BODY WEIGHT CYTOPLASMIC ORGANELLES DURACION DURATION DUREE ENZYMIC ACTIVITY EXCRECION EXCRETION FARMACOLOGIA FASCIOLA HEPATICA Fascioliasis - drug therapy Fascioliasis - metabolism Fascioliasis - veterinary FOIE GAMMA-GLUTAMYLTRANSFERASE gamma-Glutamyltransferase - blood GLUTAMATE DEHYDROGENASE Glutamate Dehydrogenase - blood GLUTAMATE DESHYDROGENASE GLUTAMATO DEHIDROGENASA HIGADO INFECTIONS Life Sciences LIVER Liver - enzymology Liver - metabolism Liver - parasitology LIVER FLUKES Male Mebendazole - administration & dosage Mebendazole - pharmacokinetics Mebendazole - therapeutic use Medical sciences METABOLITE METABOLITES METABOLITOS METACERCARIAE METHODE D'APPLICATION METODOS DE APLICACION MICROSOMES Microsomes, Liver - enzymology ORAL ADMINISTRATION ORGANITE CELLULAIRE ORGANULOS CITOPLASMICOS ORINA OVIN OVINOS Oxidation-Reduction PATHOGENESE PATHOGENESIS PATOGENESIS PESO PHARMACOLOGIE PHARMACOLOGY Pharmacology. Drug treatments PLASMA SANGUIN PLASMA SANGUINEO POIDS SHEEP Sheep Diseases - drug therapy Sheep Diseases - metabolism THIABENDAZOLE Thiabendazole - administration & dosage Thiabendazole - pharmacokinetics Thiabendazole - therapeutic use TIABENDAZOL TRANSFERASAS TRANSFERASE TRANSFERASES TREMATODA URINE WEIGHT
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