Exclusion of two candidate genes, Spnb-2 and Ddc, for the wobbler spinal muscular atrophy gene on proximal mouse Chromosome 11

In order to test the possible involvement of Spnb-2 and Ddc in the wobbler disease, we have studied their segregation in an interspecies cross in direct comparison with that of the wr gene. An approach that combined the analysis of a functional candidate gene with mapping information has led to the molecular identification of the myotonia gene adr in the mouse.