Age-related changes in the function of the pituitary-gonadal axis in a sterile male rat mutant (hd/hd)
Testicular growth is depressed in the genetically sterile male rat (hd/hd) relative to its LE phenotype littermates (by 50% and 73% at 27 and 90 days of age, respectively). Within the hd/hd testis, both the tubular and seminiferous tubule tissues are affected by the mutation. In addition, there is s...
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| Veröffentlicht in: | Biology of reproduction 1991-07, Vol.45 (1), p.11-19 |
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| creator | KAMTCHOUING, P HOCHEREAU DE REVIERS, M. T PERREAU, C PAPADOPOULOS, V DROSDOWSKY, M. A CARREAU, S |
| description | Testicular growth is depressed in the genetically sterile male rat (hd/hd) relative to its LE phenotype littermates (by 50%
and 73% at 27 and 90 days of age, respectively). Within the hd/hd testis, both the tubular and seminiferous tubule tissues
are affected by the mutation. In addition, there is significantly less germ cell production from the primary spermatocyte
stage of spermatogenesis onwards and the total number of Sertoli cells observed is less. In the intertubular tissue, the total
volume and the total number of Leydig cells per testis is significantly less, but the mean volume of an average Leydig cell
is not modified. The serum gonadotropin levels are higher in the hd/hd rat, whereas from 40 days of age onwards the level
of testosterone is lower. The FSH and LH binding affinity constants are unchanged by the mutation; however, the total number
of FSH binding sites per 10(6) Sertoli cells is lower while that of LH per 10(6) Leydig cells is greater. Indeed, it is likely
that the lesser concentration of serum testosterone in the hd/hd rat is a result of a smaller number of Leydig cells since
their individual function is not modified. The testicular androgen binding protein (ABP) content and the ABP output towards
the epididymis are lower as a consequence of both a lesser number and an altered function of the Sertoli cells. |
| doi_str_mv | 10.1095/biolreprod45.1.11 |
| format | Article |
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and 73% at 27 and 90 days of age, respectively). Within the hd/hd testis, both the tubular and seminiferous tubule tissues
are affected by the mutation. In addition, there is significantly less germ cell production from the primary spermatocyte
stage of spermatogenesis onwards and the total number of Sertoli cells observed is less. In the intertubular tissue, the total
volume and the total number of Leydig cells per testis is significantly less, but the mean volume of an average Leydig cell
is not modified. The serum gonadotropin levels are higher in the hd/hd rat, whereas from 40 days of age onwards the level
of testosterone is lower. The FSH and LH binding affinity constants are unchanged by the mutation; however, the total number
of FSH binding sites per 10(6) Sertoli cells is lower while that of LH per 10(6) Leydig cells is greater. Indeed, it is likely
that the lesser concentration of serum testosterone in the hd/hd rat is a result of a smaller number of Leydig cells since
their individual function is not modified. The testicular androgen binding protein (ABP) content and the ABP output towards
the epididymis are lower as a consequence of both a lesser number and an altered function of the Sertoli cells.</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod45.1.11</identifier><identifier>PMID: 1908710</identifier><identifier>CODEN: BIREBV</identifier><language>eng</language><publisher>Madison, WI: Society for the Study of Reproduction</publisher><subject>Aging - metabolism ; Aging - physiology ; Androgen-Binding Protein - blood ; Animals ; Biological and medical sciences ; Birth control ; Cell Division - physiology ; Chorionic Gonadotropin - blood ; Computer Science ; Follicle Stimulating Hormone - blood ; Gonadotropins - blood ; Gynecology. Andrology. Obstetrics ; Infertility, Male - physiopathology ; Leydig Cells - cytology ; Leydig Cells - metabolism ; Leydig Cells - physiology ; Life Sciences ; Luteinizing Hormone - blood ; Male ; Medical sciences ; Organ Size - physiology ; Pituitary Gland - metabolism ; Pituitary Gland - physiology ; Rats ; Rats, Mutant Strains - metabolism ; Rats, Mutant Strains - physiology ; Seminiferous Tubules - cytology ; Seminiferous Tubules - metabolism ; Seminiferous Tubules - physiology ; Sertoli Cells - cytology ; Sertoli Cells - metabolism ; Sertoli Cells - physiology ; Sperm Count ; Sterility. Assisted procreation ; Testis - cytology ; Testis - metabolism ; Testis - physiology ; Testosterone - blood</subject><ispartof>Biology of reproduction, 1991-07, Vol.45 (1), p.11-19</ispartof><rights>1992 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4959455$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1908710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02707049$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>KAMTCHOUING, P</creatorcontrib><creatorcontrib>HOCHEREAU DE REVIERS, M. T</creatorcontrib><creatorcontrib>PERREAU, C</creatorcontrib><creatorcontrib>PAPADOPOULOS, V</creatorcontrib><creatorcontrib>DROSDOWSKY, M. A</creatorcontrib><creatorcontrib>CARREAU, S</creatorcontrib><title>Age-related changes in the function of the pituitary-gonadal axis in a sterile male rat mutant (hd/hd)</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>Testicular growth is depressed in the genetically sterile male rat (hd/hd) relative to its LE phenotype littermates (by 50%
and 73% at 27 and 90 days of age, respectively). Within the hd/hd testis, both the tubular and seminiferous tubule tissues
are affected by the mutation. In addition, there is significantly less germ cell production from the primary spermatocyte
stage of spermatogenesis onwards and the total number of Sertoli cells observed is less. In the intertubular tissue, the total
volume and the total number of Leydig cells per testis is significantly less, but the mean volume of an average Leydig cell
is not modified. The serum gonadotropin levels are higher in the hd/hd rat, whereas from 40 days of age onwards the level
of testosterone is lower. The FSH and LH binding affinity constants are unchanged by the mutation; however, the total number
of FSH binding sites per 10(6) Sertoli cells is lower while that of LH per 10(6) Leydig cells is greater. Indeed, it is likely
that the lesser concentration of serum testosterone in the hd/hd rat is a result of a smaller number of Leydig cells since
their individual function is not modified. The testicular androgen binding protein (ABP) content and the ABP output towards
the epididymis are lower as a consequence of both a lesser number and an altered function of the Sertoli cells.</description><subject>Aging - metabolism</subject><subject>Aging - physiology</subject><subject>Androgen-Binding Protein - blood</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Cell Division - physiology</subject><subject>Chorionic Gonadotropin - blood</subject><subject>Computer Science</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gonadotropins - blood</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Infertility, Male - physiopathology</subject><subject>Leydig Cells - cytology</subject><subject>Leydig Cells - metabolism</subject><subject>Leydig Cells - physiology</subject><subject>Life Sciences</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Organ Size - physiology</subject><subject>Pituitary Gland - metabolism</subject><subject>Pituitary Gland - physiology</subject><subject>Rats</subject><subject>Rats, Mutant Strains - metabolism</subject><subject>Rats, Mutant Strains - physiology</subject><subject>Seminiferous Tubules - cytology</subject><subject>Seminiferous Tubules - metabolism</subject><subject>Seminiferous Tubules - physiology</subject><subject>Sertoli Cells - cytology</subject><subject>Sertoli Cells - metabolism</subject><subject>Sertoli Cells - physiology</subject><subject>Sperm Count</subject><subject>Sterility. Assisted procreation</subject><subject>Testis - cytology</subject><subject>Testis - metabolism</subject><subject>Testis - physiology</subject><subject>Testosterone - blood</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtrHDEQhEVIcNZOfkAOAR1CsA-z1ntGx8XYcWDBF-csevXYUdDMbCSNN_n3mdiLc-mmuz6KohD6RMmaEi2vd3FK2R_y5IRc0zWlb9CKSqablqnuLVoRQlTDueLv0XkpPwmhgjN-hs6oJl1LyQqFzd432Seo3mHbw7j3BccR197jMI-2xmnEU3i-D7HOsUL-0-ynERwkDL_jMw24VJ9j8niAZWSoeJgrjBVf9u66d1cf0LsAqfiPp32BftzdPt7cN9uHb99vNtumZ7qrTWdpS4VtmRBB-c4JGzgTTAUOnSNeCeGllFpZ2wJVO9E5RXjQChjXygvNL9DVi28PyRxyHJa0ZoJo7jdb8-9HWEtaIvQTXdivL-zS36_Zl2qGWKxPCUY_zcW0jEipKFvAzydw3g3evfqeSlz0LycdioUUMow2lldMaKmFlP-xPu77Y8zelKWttJhyczwehTTUUMr_Au8MjTw</recordid><startdate>19910701</startdate><enddate>19910701</enddate><creator>KAMTCHOUING, P</creator><creator>HOCHEREAU DE REVIERS, M. T</creator><creator>PERREAU, C</creator><creator>PAPADOPOULOS, V</creator><creator>DROSDOWSKY, M. A</creator><creator>CARREAU, S</creator><general>Society for the Study of Reproduction</general><general>Society for the Study of Reproduction - Oxford Academic</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>19910701</creationdate><title>Age-related changes in the function of the pituitary-gonadal axis in a sterile male rat mutant (hd/hd)</title><author>KAMTCHOUING, P ; HOCHEREAU DE REVIERS, M. T ; PERREAU, C ; PAPADOPOULOS, V ; DROSDOWSKY, M. A ; CARREAU, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h298t-8c1714c7244f6e8d4cf32426f3a8d0e644e55596cc7a16b48d603f96a2396e493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Aging - metabolism</topic><topic>Aging - physiology</topic><topic>Androgen-Binding Protein - blood</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Cell Division - physiology</topic><topic>Chorionic Gonadotropin - blood</topic><topic>Computer Science</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gonadotropins - blood</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Infertility, Male - physiopathology</topic><topic>Leydig Cells - cytology</topic><topic>Leydig Cells - metabolism</topic><topic>Leydig Cells - physiology</topic><topic>Life Sciences</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Organ Size - physiology</topic><topic>Pituitary Gland - metabolism</topic><topic>Pituitary Gland - physiology</topic><topic>Rats</topic><topic>Rats, Mutant Strains - metabolism</topic><topic>Rats, Mutant Strains - physiology</topic><topic>Seminiferous Tubules - cytology</topic><topic>Seminiferous Tubules - metabolism</topic><topic>Seminiferous Tubules - physiology</topic><topic>Sertoli Cells - cytology</topic><topic>Sertoli Cells - metabolism</topic><topic>Sertoli Cells - physiology</topic><topic>Sperm Count</topic><topic>Sterility. Assisted procreation</topic><topic>Testis - cytology</topic><topic>Testis - metabolism</topic><topic>Testis - physiology</topic><topic>Testosterone - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAMTCHOUING, P</creatorcontrib><creatorcontrib>HOCHEREAU DE REVIERS, M. T</creatorcontrib><creatorcontrib>PERREAU, C</creatorcontrib><creatorcontrib>PAPADOPOULOS, V</creatorcontrib><creatorcontrib>DROSDOWSKY, M. A</creatorcontrib><creatorcontrib>CARREAU, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAMTCHOUING, P</au><au>HOCHEREAU DE REVIERS, M. T</au><au>PERREAU, C</au><au>PAPADOPOULOS, V</au><au>DROSDOWSKY, M. A</au><au>CARREAU, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-related changes in the function of the pituitary-gonadal axis in a sterile male rat mutant (hd/hd)</atitle><jtitle>Biology of reproduction</jtitle><addtitle>Biol Reprod</addtitle><date>1991-07-01</date><risdate>1991</risdate><volume>45</volume><issue>1</issue><spage>11</spage><epage>19</epage><pages>11-19</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><coden>BIREBV</coden><abstract>Testicular growth is depressed in the genetically sterile male rat (hd/hd) relative to its LE phenotype littermates (by 50%
and 73% at 27 and 90 days of age, respectively). Within the hd/hd testis, both the tubular and seminiferous tubule tissues
are affected by the mutation. In addition, there is significantly less germ cell production from the primary spermatocyte
stage of spermatogenesis onwards and the total number of Sertoli cells observed is less. In the intertubular tissue, the total
volume and the total number of Leydig cells per testis is significantly less, but the mean volume of an average Leydig cell
is not modified. The serum gonadotropin levels are higher in the hd/hd rat, whereas from 40 days of age onwards the level
of testosterone is lower. The FSH and LH binding affinity constants are unchanged by the mutation; however, the total number
of FSH binding sites per 10(6) Sertoli cells is lower while that of LH per 10(6) Leydig cells is greater. Indeed, it is likely
that the lesser concentration of serum testosterone in the hd/hd rat is a result of a smaller number of Leydig cells since
their individual function is not modified. The testicular androgen binding protein (ABP) content and the ABP output towards
the epididymis are lower as a consequence of both a lesser number and an altered function of the Sertoli cells.</abstract><cop>Madison, WI</cop><pub>Society for the Study of Reproduction</pub><pmid>1908710</pmid><doi>10.1095/biolreprod45.1.11</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-3363 |
| ispartof | Biology of reproduction, 1991-07, Vol.45 (1), p.11-19 |
| issn | 0006-3363 1529-7268 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02707049v1 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Aging - metabolism Aging - physiology Androgen-Binding Protein - blood Animals Biological and medical sciences Birth control Cell Division - physiology Chorionic Gonadotropin - blood Computer Science Follicle Stimulating Hormone - blood Gonadotropins - blood Gynecology. Andrology. Obstetrics Infertility, Male - physiopathology Leydig Cells - cytology Leydig Cells - metabolism Leydig Cells - physiology Life Sciences Luteinizing Hormone - blood Male Medical sciences Organ Size - physiology Pituitary Gland - metabolism Pituitary Gland - physiology Rats Rats, Mutant Strains - metabolism Rats, Mutant Strains - physiology Seminiferous Tubules - cytology Seminiferous Tubules - metabolism Seminiferous Tubules - physiology Sertoli Cells - cytology Sertoli Cells - metabolism Sertoli Cells - physiology Sperm Count Sterility. Assisted procreation Testis - cytology Testis - metabolism Testis - physiology Testosterone - blood |
| title | Age-related changes in the function of the pituitary-gonadal axis in a sterile male rat mutant (hd/hd) |
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