Differential effects of lipid and carbohydrate on enterocyte lactase activity in newborn piglets
The influence of enteral feeding in the neonate on lactase-phlorizin hydrolase activity in the small intestine has been determined in newborn piglets fed a series of modified colostra, with a controlled metabolizable energy intake, during the first 31.5 h of life. Striking differences were observed...
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| Veröffentlicht in: | Experimental physiology 1994-03, Vol.79 (2), p.189-201 |
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| creator | Tivey, DR Le Dividich, J Herpin, P Brown, D Dauncey, MJ |
| description | The influence of enteral feeding in the neonate on lactase-phlorizin hydrolase activity in the small intestine has been determined
in newborn piglets fed a series of modified colostra, with a controlled metabolizable energy intake, during the first 31.5
h of life. Striking differences were observed between lactase specific activity in mucosal homogenates and enterocyte lactase
activity along the villus axis; compared with newborns, the former decreased after feeding colostrum, whereas the latter increased
significantly. When lipid was present in adequate amount, the increase in enterocyte lactase activity occurred when carbohydrate
was present as either lactose or galactose. However, when the lipid content of the diet was low, there was a specific effect
of carbohydrate composition which was dependent on position along the villus axis: in the lower villus, colostra high in lactose
or glucose stimulated an increase in lactase, but there was no such effect with a high galactose intake. It is concluded that
colostrum increases enterocyte lactase activity during the first day of life, and that this is dependent on both the nutrient
composition of the diet and the position of the enterocytes along the villus. |
| doi_str_mv | 10.1113/expphysiol.1994.sp003752 |
| format | Article |
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in newborn piglets fed a series of modified colostra, with a controlled metabolizable energy intake, during the first 31.5
h of life. Striking differences were observed between lactase specific activity in mucosal homogenates and enterocyte lactase
activity along the villus axis; compared with newborns, the former decreased after feeding colostrum, whereas the latter increased
significantly. When lipid was present in adequate amount, the increase in enterocyte lactase activity occurred when carbohydrate
was present as either lactose or galactose. However, when the lipid content of the diet was low, there was a specific effect
of carbohydrate composition which was dependent on position along the villus axis: in the lower villus, colostra high in lactose
or glucose stimulated an increase in lactase, but there was no such effect with a high galactose intake. It is concluded that
colostrum increases enterocyte lactase activity during the first day of life, and that this is dependent on both the nutrient
composition of the diet and the position of the enterocytes along the villus.</description><identifier>ISSN: 0958-0670</identifier><identifier>EISSN: 1469-445X</identifier><identifier>DOI: 10.1113/expphysiol.1994.sp003752</identifier><identifier>PMID: 8003303</identifier><language>eng</language><publisher>Cambridge: The Physiological Society</publisher><subject>Animals ; Animals, Newborn - metabolism ; beta-Galactosidase - metabolism ; Biological and medical sciences ; Carbohydrates - pharmacology ; Colostrum - physiology ; Energy Intake ; Fundamental and applied biological sciences. Psychology ; Histocytochemistry ; Insulin - blood ; Intestinal Mucosa - enzymology ; Intestine. Mesentery ; Intestines - cytology ; Intestines - metabolism ; Lactase ; Lactase-Phlorizin Hydrolase - metabolism ; Life Sciences ; Lipids - pharmacology ; Osmolar Concentration ; Swine - metabolism ; Vertebrates: digestive system</subject><ispartof>Experimental physiology, 1994-03, Vol.79 (2), p.189-201</ispartof><rights>1994 The Physiological Society</rights><rights>1994 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5149-daa1d20edd6f6ea7653dd71635a11d2048b0fc8081bf63f20fdf1c4b0ea25fbe3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1113%2Fexpphysiol.1994.sp003752$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1113%2Fexpphysiol.1994.sp003752$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4055249$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8003303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02705859$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Tivey, DR</creatorcontrib><creatorcontrib>Le Dividich, J</creatorcontrib><creatorcontrib>Herpin, P</creatorcontrib><creatorcontrib>Brown, D</creatorcontrib><creatorcontrib>Dauncey, MJ</creatorcontrib><title>Differential effects of lipid and carbohydrate on enterocyte lactase activity in newborn piglets</title><title>Experimental physiology</title><addtitle>Exp Physiol</addtitle><description>The influence of enteral feeding in the neonate on lactase-phlorizin hydrolase activity in the small intestine has been determined
in newborn piglets fed a series of modified colostra, with a controlled metabolizable energy intake, during the first 31.5
h of life. Striking differences were observed between lactase specific activity in mucosal homogenates and enterocyte lactase
activity along the villus axis; compared with newborns, the former decreased after feeding colostrum, whereas the latter increased
significantly. When lipid was present in adequate amount, the increase in enterocyte lactase activity occurred when carbohydrate
was present as either lactose or galactose. However, when the lipid content of the diet was low, there was a specific effect
of carbohydrate composition which was dependent on position along the villus axis: in the lower villus, colostra high in lactose
or glucose stimulated an increase in lactase, but there was no such effect with a high galactose intake. It is concluded that
colostrum increases enterocyte lactase activity during the first day of life, and that this is dependent on both the nutrient
composition of the diet and the position of the enterocytes along the villus.</description><subject>Animals</subject><subject>Animals, Newborn - metabolism</subject><subject>beta-Galactosidase - metabolism</subject><subject>Biological and medical sciences</subject><subject>Carbohydrates - pharmacology</subject><subject>Colostrum - physiology</subject><subject>Energy Intake</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Histocytochemistry</subject><subject>Insulin - blood</subject><subject>Intestinal Mucosa - enzymology</subject><subject>Intestine. Mesentery</subject><subject>Intestines - cytology</subject><subject>Intestines - metabolism</subject><subject>Lactase</subject><subject>Lactase-Phlorizin Hydrolase - metabolism</subject><subject>Life Sciences</subject><subject>Lipids - pharmacology</subject><subject>Osmolar Concentration</subject><subject>Swine - metabolism</subject><subject>Vertebrates: digestive system</subject><issn>0958-0670</issn><issn>1469-445X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2P0zAQhi0EWsrCT0DyASFxSBkndj6Oq7JskSrBASRuxrHHWyM3Dna6Jf9-E6V0r5zGnnlm3rFfQiiDNWOs-Ih_-34_Jhf8mjUNX6ceoKhE_oysGC-bjHPx8zlZQSPqDMoKXpJXKf0GYAXU_Ipc1RNeQLEivz45azFiNzjlKU5nPSQaLPWud4aqzlCtYhv2o4lqQBo6OrEYgx6nm1d6UAnpFNyDG0bqOtrhqQ2xo7279zik1-SFVT7hm3O8Jj8-337fbLPd17svm5tdpgXjTWaUYiYHNKa0JaqqFIUxFSsLodhc4HULVtdQs9aWhc3BGss0bwFVLmyLxTX5sMzdKy_76A4qjjIoJ7c3OznnIK9A1KJ5YBP7fmH7GP4cMQ3y4JJG71WH4ZjkpM4BqmYC6wXUMaQU0V4mM5CzEfLJCDkbIf8ZMbW-PWsc2wOaS-P556f6u3NdJa28jarTLl0wDkLkfN5gs2An53H8b3l5-207J6omZ3Xz9OC9u9-fXES5dKWgHQ6jrBqZyxl8BHiVuas</recordid><startdate>19940301</startdate><enddate>19940301</enddate><creator>Tivey, DR</creator><creator>Le Dividich, J</creator><creator>Herpin, P</creator><creator>Brown, D</creator><creator>Dauncey, MJ</creator><general>The Physiological Society</general><general>Cambridge University Press</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>19940301</creationdate><title>Differential effects of lipid and carbohydrate on enterocyte lactase activity in newborn piglets</title><author>Tivey, DR ; Le Dividich, J ; Herpin, P ; Brown, D ; Dauncey, MJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5149-daa1d20edd6f6ea7653dd71635a11d2048b0fc8081bf63f20fdf1c4b0ea25fbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Animals, Newborn - metabolism</topic><topic>beta-Galactosidase - metabolism</topic><topic>Biological and medical sciences</topic><topic>Carbohydrates - pharmacology</topic><topic>Colostrum - physiology</topic><topic>Energy Intake</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Histocytochemistry</topic><topic>Insulin - blood</topic><topic>Intestinal Mucosa - enzymology</topic><topic>Intestine. Mesentery</topic><topic>Intestines - cytology</topic><topic>Intestines - metabolism</topic><topic>Lactase</topic><topic>Lactase-Phlorizin Hydrolase - metabolism</topic><topic>Life Sciences</topic><topic>Lipids - pharmacology</topic><topic>Osmolar Concentration</topic><topic>Swine - metabolism</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tivey, DR</creatorcontrib><creatorcontrib>Le Dividich, J</creatorcontrib><creatorcontrib>Herpin, P</creatorcontrib><creatorcontrib>Brown, D</creatorcontrib><creatorcontrib>Dauncey, MJ</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Experimental physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tivey, DR</au><au>Le Dividich, J</au><au>Herpin, P</au><au>Brown, D</au><au>Dauncey, MJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential effects of lipid and carbohydrate on enterocyte lactase activity in newborn piglets</atitle><jtitle>Experimental physiology</jtitle><addtitle>Exp Physiol</addtitle><date>1994-03-01</date><risdate>1994</risdate><volume>79</volume><issue>2</issue><spage>189</spage><epage>201</epage><pages>189-201</pages><issn>0958-0670</issn><eissn>1469-445X</eissn><abstract>The influence of enteral feeding in the neonate on lactase-phlorizin hydrolase activity in the small intestine has been determined
in newborn piglets fed a series of modified colostra, with a controlled metabolizable energy intake, during the first 31.5
h of life. Striking differences were observed between lactase specific activity in mucosal homogenates and enterocyte lactase
activity along the villus axis; compared with newborns, the former decreased after feeding colostrum, whereas the latter increased
significantly. When lipid was present in adequate amount, the increase in enterocyte lactase activity occurred when carbohydrate
was present as either lactose or galactose. However, when the lipid content of the diet was low, there was a specific effect
of carbohydrate composition which was dependent on position along the villus axis: in the lower villus, colostra high in lactose
or glucose stimulated an increase in lactase, but there was no such effect with a high galactose intake. It is concluded that
colostrum increases enterocyte lactase activity during the first day of life, and that this is dependent on both the nutrient
composition of the diet and the position of the enterocytes along the villus.</abstract><cop>Cambridge</cop><pub>The Physiological Society</pub><pmid>8003303</pmid><doi>10.1113/expphysiol.1994.sp003752</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Experimental physiology, 1994-03, Vol.79 (2), p.189-201 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Animals Animals, Newborn - metabolism beta-Galactosidase - metabolism Biological and medical sciences Carbohydrates - pharmacology Colostrum - physiology Energy Intake Fundamental and applied biological sciences. Psychology Histocytochemistry Insulin - blood Intestinal Mucosa - enzymology Intestine. Mesentery Intestines - cytology Intestines - metabolism Lactase Lactase-Phlorizin Hydrolase - metabolism Life Sciences Lipids - pharmacology Osmolar Concentration Swine - metabolism Vertebrates: digestive system |
| title | Differential effects of lipid and carbohydrate on enterocyte lactase activity in newborn piglets |
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