Inducing effect of oxfendazole on cytochrome P450IA2 in rabbit liver: Consequences on cytochrome P450 dependent monooxygenases

Male New Zealand rabbits were dosed with either 0.9, 4.5 or 22.5 mg/kg/day of oxfendazole by gastric intubation for 10 days. Oxfendazole administered at the therapeutic dose (4.5 mg/kg) and at the highest dose (22.5 mg/kg) increased 1.54- and 2.36-fold the total liver microsomal cytochrome P450 and...

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Veröffentlicht in:	Biochemical pharmacology 1991-06, Vol.41 (12), p.1813-1820
Hauptverfasser:	Gleizes, Chantal, Eeckhoutte, Claudine, Pineau, Thierry, Alvinerie, Michel, Galtier, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antinematodal Agents - pharmacology Antiparasitic agents Benzimidazoles - pharmacology Biological and medical sciences Cytochrome P-450 CYP1A2 Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - metabolism Enzyme Induction Female Isoenzymes - metabolism Life Sciences Liver - drug effects Liver - enzymology Male Medical sciences Microsomes, Liver - drug effects Microsomes, Liver - enzymology Mixed Function Oxygenases - metabolism Oxidoreductases - biosynthesis Pharmacology. Drug treatments Rabbits RNA, Messenger - metabolism
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