Stability of brain content of magnesium in experimental hypomagnesemia
Magnesium is important in cerebral function. If there is a deficiency and neurological symptoms accrue, we hypothesised that Mg 2+ deficiency causes neurological symptoms by decreasing the level of Mg 2+ in cerebral tissue. The content of magnesium was determined in 12 brain structures in magnesium-...
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| Veröffentlicht in: | Brain research 1997-09, Vol.769 (2), p.329-332 |
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| creator | Poenaru, S Manicom, R Rouhani, S Aymard, P Bajenaru, O Rayssiguier, Y Emmanouillidis, E Gueux, E Nkanga, N Durlach, J Dall'ava, J |
| description | Magnesium is important in cerebral function. If there is a deficiency and neurological symptoms accrue, we hypothesised that Mg
2+ deficiency causes neurological symptoms by decreasing the level of Mg
2+ in cerebral tissue. The content of magnesium was determined in 12 brain structures in magnesium-deficient rats. Experiments were carried out for 40 days in two groups of Wistar male rats made magnesium-deficient (MD) by a well-controlled diet (50 mg of Mg
2+/kg of food), and a control group (CG) rats fed normal diet (1 g of Mg
2+/kg of food). At the end of the 40 days, the clinical signs of hypomagnesemia were sought in the MD rats and Mg
2+ concentration levels were measured in the blood and brain. The results showed variable distribution of Mg
2+ in the different brain structures, both in CG and MD rats; in the MD rats there is an important stability of global Mg
2+ content of the brain. Although the global values for Mg
2+ in the brain did not decline in MD rats, there was a significant decrease in Mg
2+ in the brainstem. We conclude that the brain is able to maintain a stable concentration of Mg
2+ during chronic hypomagnesemia, but its topographic variations could account for some of neurological signs accompanying this condition. |
| doi_str_mv | 10.1016/S0006-8993(97)00725-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02697988v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006899397007257</els_id><sourcerecordid>79420105</sourcerecordid><originalsourceid>FETCH-LOGICAL-c425t-d2933e91a0c30a88546c41e35dce2bc15515e37385245ff3c660ff5b2c2e4e263</originalsourceid><addsrcrecordid>eNqFUU1LxDAUDKLouvoTFnoSPVTz0STNSUTUFRY8qOeQpq8aaZvadMX996Z22eueHm9m3gczCC0IviaYiJtXjLFIc6XYpZJXGEvKU3mAZiSXNBU0w4dotpOcoNMQvmLLmMLH6FgxmVFMZ-jxdTCFq92wSXyVFL1xbWJ9O0A7jEBjPloIbt0kEYffDnrXRMrUyeem8xMLjTNn6KgydYDzbZ2j98eHt_tlunp5er6_W6U2o3xIS6oYA0UMtgybPOeZsBkBxksLtLCEc8KBSZZzmvGqYlYIXFW8oJZCBlSwObqa9n6aWnfxGdNvtDdOL-9WesQwFUqqPP8hUXsxabvef68hDLpxwUJdmxb8OmipogUE871CIijhkowb-SS0vQ-hh2r3AsF6DEX_h6JHx7WS-j8ULePcYntgXTRQ7qa2KUT-duIhWvfjoNfBOmgtlK4HO-jSuz0X_gDWeJqB</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16215711</pqid></control><display><type>article</type><title>Stability of brain content of magnesium in experimental hypomagnesemia</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Poenaru, S ; Manicom, R ; Rouhani, S ; Aymard, P ; Bajenaru, O ; Rayssiguier, Y ; Emmanouillidis, E ; Gueux, E ; Nkanga, N ; Durlach, J ; Dall'ava, J</creator><creatorcontrib>Poenaru, S ; Manicom, R ; Rouhani, S ; Aymard, P ; Bajenaru, O ; Rayssiguier, Y ; Emmanouillidis, E ; Gueux, E ; Nkanga, N ; Durlach, J ; Dall'ava, J</creatorcontrib><description>Magnesium is important in cerebral function. If there is a deficiency and neurological symptoms accrue, we hypothesised that Mg
2+ deficiency causes neurological symptoms by decreasing the level of Mg
2+ in cerebral tissue. The content of magnesium was determined in 12 brain structures in magnesium-deficient rats. Experiments were carried out for 40 days in two groups of Wistar male rats made magnesium-deficient (MD) by a well-controlled diet (50 mg of Mg
2+/kg of food), and a control group (CG) rats fed normal diet (1 g of Mg
2+/kg of food). At the end of the 40 days, the clinical signs of hypomagnesemia were sought in the MD rats and Mg
2+ concentration levels were measured in the blood and brain. The results showed variable distribution of Mg
2+ in the different brain structures, both in CG and MD rats; in the MD rats there is an important stability of global Mg
2+ content of the brain. Although the global values for Mg
2+ in the brain did not decline in MD rats, there was a significant decrease in Mg
2+ in the brainstem. We conclude that the brain is able to maintain a stable concentration of Mg
2+ during chronic hypomagnesemia, but its topographic variations could account for some of neurological signs accompanying this condition.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>EISSN: 0006-8993</identifier><identifier>DOI: 10.1016/S0006-8993(97)00725-7</identifier><identifier>PMID: 9374202</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Brain - metabolism ; Brain structure ; Life Sciences ; Magnesium - metabolism ; Magnesium brain content ; Magnesium Deficiency - blood ; Magnesium Deficiency - metabolism ; Magnesium-deficient rat ; Male ; Osmolar Concentration ; Rats ; Rats, Wistar ; Tissue Distribution</subject><ispartof>Brain research, 1997-09, Vol.769 (2), p.329-332</ispartof><rights>1997 Elsevier Science B.V.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-d2933e91a0c30a88546c41e35dce2bc15515e37385245ff3c660ff5b2c2e4e263</citedby><cites>FETCH-LOGICAL-c425t-d2933e91a0c30a88546c41e35dce2bc15515e37385245ff3c660ff5b2c2e4e263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-8993(97)00725-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9374202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02697988$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Poenaru, S</creatorcontrib><creatorcontrib>Manicom, R</creatorcontrib><creatorcontrib>Rouhani, S</creatorcontrib><creatorcontrib>Aymard, P</creatorcontrib><creatorcontrib>Bajenaru, O</creatorcontrib><creatorcontrib>Rayssiguier, Y</creatorcontrib><creatorcontrib>Emmanouillidis, E</creatorcontrib><creatorcontrib>Gueux, E</creatorcontrib><creatorcontrib>Nkanga, N</creatorcontrib><creatorcontrib>Durlach, J</creatorcontrib><creatorcontrib>Dall'ava, J</creatorcontrib><title>Stability of brain content of magnesium in experimental hypomagnesemia</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Magnesium is important in cerebral function. If there is a deficiency and neurological symptoms accrue, we hypothesised that Mg
2+ deficiency causes neurological symptoms by decreasing the level of Mg
2+ in cerebral tissue. The content of magnesium was determined in 12 brain structures in magnesium-deficient rats. Experiments were carried out for 40 days in two groups of Wistar male rats made magnesium-deficient (MD) by a well-controlled diet (50 mg of Mg
2+/kg of food), and a control group (CG) rats fed normal diet (1 g of Mg
2+/kg of food). At the end of the 40 days, the clinical signs of hypomagnesemia were sought in the MD rats and Mg
2+ concentration levels were measured in the blood and brain. The results showed variable distribution of Mg
2+ in the different brain structures, both in CG and MD rats; in the MD rats there is an important stability of global Mg
2+ content of the brain. Although the global values for Mg
2+ in the brain did not decline in MD rats, there was a significant decrease in Mg
2+ in the brainstem. We conclude that the brain is able to maintain a stable concentration of Mg
2+ during chronic hypomagnesemia, but its topographic variations could account for some of neurological signs accompanying this condition.</description><subject>Animals</subject><subject>Brain - metabolism</subject><subject>Brain structure</subject><subject>Life Sciences</subject><subject>Magnesium - metabolism</subject><subject>Magnesium brain content</subject><subject>Magnesium Deficiency - blood</subject><subject>Magnesium Deficiency - metabolism</subject><subject>Magnesium-deficient rat</subject><subject>Male</subject><subject>Osmolar Concentration</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Tissue Distribution</subject><issn>0006-8993</issn><issn>1872-6240</issn><issn>0006-8993</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1LxDAUDKLouvoTFnoSPVTz0STNSUTUFRY8qOeQpq8aaZvadMX996Z22eueHm9m3gczCC0IviaYiJtXjLFIc6XYpZJXGEvKU3mAZiSXNBU0w4dotpOcoNMQvmLLmMLH6FgxmVFMZ-jxdTCFq92wSXyVFL1xbWJ9O0A7jEBjPloIbt0kEYffDnrXRMrUyeem8xMLjTNn6KgydYDzbZ2j98eHt_tlunp5er6_W6U2o3xIS6oYA0UMtgybPOeZsBkBxksLtLCEc8KBSZZzmvGqYlYIXFW8oJZCBlSwObqa9n6aWnfxGdNvtDdOL-9WesQwFUqqPP8hUXsxabvef68hDLpxwUJdmxb8OmipogUE871CIijhkowb-SS0vQ-hh2r3AsF6DEX_h6JHx7WS-j8ULePcYntgXTRQ7qa2KUT-duIhWvfjoNfBOmgtlK4HO-jSuz0X_gDWeJqB</recordid><startdate>19970926</startdate><enddate>19970926</enddate><creator>Poenaru, S</creator><creator>Manicom, R</creator><creator>Rouhani, S</creator><creator>Aymard, P</creator><creator>Bajenaru, O</creator><creator>Rayssiguier, Y</creator><creator>Emmanouillidis, E</creator><creator>Gueux, E</creator><creator>Nkanga, N</creator><creator>Durlach, J</creator><creator>Dall'ava, J</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>19970926</creationdate><title>Stability of brain content of magnesium in experimental hypomagnesemia</title><author>Poenaru, S ; Manicom, R ; Rouhani, S ; Aymard, P ; Bajenaru, O ; Rayssiguier, Y ; Emmanouillidis, E ; Gueux, E ; Nkanga, N ; Durlach, J ; Dall'ava, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-d2933e91a0c30a88546c41e35dce2bc15515e37385245ff3c660ff5b2c2e4e263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Brain - metabolism</topic><topic>Brain structure</topic><topic>Life Sciences</topic><topic>Magnesium - metabolism</topic><topic>Magnesium brain content</topic><topic>Magnesium Deficiency - blood</topic><topic>Magnesium Deficiency - metabolism</topic><topic>Magnesium-deficient rat</topic><topic>Male</topic><topic>Osmolar Concentration</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Poenaru, S</creatorcontrib><creatorcontrib>Manicom, R</creatorcontrib><creatorcontrib>Rouhani, S</creatorcontrib><creatorcontrib>Aymard, P</creatorcontrib><creatorcontrib>Bajenaru, O</creatorcontrib><creatorcontrib>Rayssiguier, Y</creatorcontrib><creatorcontrib>Emmanouillidis, E</creatorcontrib><creatorcontrib>Gueux, E</creatorcontrib><creatorcontrib>Nkanga, N</creatorcontrib><creatorcontrib>Durlach, J</creatorcontrib><creatorcontrib>Dall'ava, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Poenaru, S</au><au>Manicom, R</au><au>Rouhani, S</au><au>Aymard, P</au><au>Bajenaru, O</au><au>Rayssiguier, Y</au><au>Emmanouillidis, E</au><au>Gueux, E</au><au>Nkanga, N</au><au>Durlach, J</au><au>Dall'ava, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stability of brain content of magnesium in experimental hypomagnesemia</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1997-09-26</date><risdate>1997</risdate><volume>769</volume><issue>2</issue><spage>329</spage><epage>332</epage><pages>329-332</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><eissn>0006-8993</eissn><abstract>Magnesium is important in cerebral function. If there is a deficiency and neurological symptoms accrue, we hypothesised that Mg
2+ deficiency causes neurological symptoms by decreasing the level of Mg
2+ in cerebral tissue. The content of magnesium was determined in 12 brain structures in magnesium-deficient rats. Experiments were carried out for 40 days in two groups of Wistar male rats made magnesium-deficient (MD) by a well-controlled diet (50 mg of Mg
2+/kg of food), and a control group (CG) rats fed normal diet (1 g of Mg
2+/kg of food). At the end of the 40 days, the clinical signs of hypomagnesemia were sought in the MD rats and Mg
2+ concentration levels were measured in the blood and brain. The results showed variable distribution of Mg
2+ in the different brain structures, both in CG and MD rats; in the MD rats there is an important stability of global Mg
2+ content of the brain. Although the global values for Mg
2+ in the brain did not decline in MD rats, there was a significant decrease in Mg
2+ in the brainstem. We conclude that the brain is able to maintain a stable concentration of Mg
2+ during chronic hypomagnesemia, but its topographic variations could account for some of neurological signs accompanying this condition.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>9374202</pmid><doi>10.1016/S0006-8993(97)00725-7</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Brain - metabolism Brain structure Life Sciences Magnesium - metabolism Magnesium brain content Magnesium Deficiency - blood Magnesium Deficiency - metabolism Magnesium-deficient rat Male Osmolar Concentration Rats Rats, Wistar Tissue Distribution |
| title | Stability of brain content of magnesium in experimental hypomagnesemia |
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