ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor

The ERBB receptors have a crucial role in morphogenesis and oncogenesis. We have identified a new PDZ protein we named ERBIN (ERBB2 interacting protein) that acts as an adaptor for the receptor ERBB2/HER2 in epithelia. ERBIN contains 16 leucine-rich repeats (LRRs) in its amino terminus and a PDZ (PS...

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Veröffentlicht in:	Nature cell biology 2000-07, Vol.2 (7), p.407-414
Hauptverfasser:	Borg, Jean-Paul, Marchetto, Sylvie, Le Bivic, André, Ollendorff, Vincent, Jaulin-Bastard, Fanny, Saito, Hiroko, Fournier, Emmanuel, Adélaïde, José, Margolis, Ben, Birnbaum, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Amino Acid Sequence Animals Binding Sites Biological Transport Biomedical and Life Sciences Caco-2 Cells Cancer Research Carrier Proteins - metabolism Cell Biology Cell Line Cell Membrane - chemistry Cell Membrane - metabolism Cell Polarity Developmental Biology Dogs Enzyme Activation Epidermal growth factor Epithelial Cells - chemistry Epithelial Cells - cytology Epithelial Cells - metabolism Fluorescent Antibody Technique Humans Intestines - cytology Kidney - metabolism Kinases Life Sciences Ligands Localization Membranes Mice Molecular Sequence Data Mutation Phosphorylation Protein Binding Protein Structure, Tertiary Protein-protein interactions Proteins Receptor, ErbB-2 - metabolism RNA, Messenger - analysis RNA, Messenger - genetics Sequence Alignment Stem Cells Substrate Specificity Two-Hybrid System Techniques
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