Potency and Selectivity of the Cathepsin L Propeptide as an Inhibitor of Cysteine Proteases

The cathepsin L propeptide (phcl-2) was expressed in Saccharomyces cerevisiae using a human procathepsin L/α-factor fusion construct containing a stop codon at position −1 (the C-terminal amino acid of the proregion). Since the yield after purification was very low, the cathepsin L propeptide was al...

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