Vagally dependent protective action of calcitonin gene-related peptide on colitis
This work evaluates the mechanism of action of calcitonin gene-related peptide (CGRP) on colitis. Firstly, Wistar rats were intracolonically instilled with trinitrobenzenesulfonic acid (TNBS) and IV treated by either αCGRP, or hCGRP(8–37), or by vehicle. The inflammatory level was evaluated 8 h and...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1999-11, Vol.20 (11), p.1367-1374 |
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| creator | Mazelin, Ludmilla Theodorou, Vassilia Fioramonti, Jean Bueno, Lionel |
| description | This work evaluates the mechanism of action of calcitonin gene-related peptide (CGRP) on colitis. Firstly, Wistar rats were intracolonically instilled with trinitrobenzenesulfonic acid (TNBS) and IV treated by either αCGRP, or hCGRP(8–37), or by vehicle. The inflammatory level was evaluated 8 h and 4 days after TNBS. Secondly, intracerebroventricular αCGRP was assessed on the 4-day group with colitis. Finally, IV αCGRP was administered in vagotomized animals, and tested on the 4-day group with colitis. Colitis was aggravated by hCGRP(8–37), and decreased by peripheral but not central αCGRP. αCGRP was inactive on inflammatory parameters in vagotomized colitic rats. This suggests that endogenous peripheral CGRP has an anti-inflammatory role in TNBS-induced colitis, depending upon the integrity of the vagus. |
| doi_str_mv | 10.1016/S0196-9781(99)00144-8 |
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This suggests that endogenous peripheral CGRP has an anti-inflammatory role in TNBS-induced colitis, depending upon the integrity of the vagus.</description><subject>Animals</subject><subject>Calcitonin Gene-Related Peptide - administration & dosage</subject><subject>Calcitonin Gene-Related Peptide - therapeutic use</subject><subject>CGRP</subject><subject>Colitis - drug therapy</subject><subject>Colitis - pathology</subject><subject>Gut inflammation</subject><subject>Injections, Intraventricular</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Myeloperoxidase</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>TNBS colitis</subject><subject>Trinitrobenzenesulfonic Acid - administration & dosage</subject><subject>Vagotomy</subject><subject>Vagus nerve</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkNFqFTEQhoMo9lh9BGWvxF6sTTbZJHMlpagVDkjR9jZkk9kaydmsm5wDfXtzuqV459XA8P3zMx8hbxn9yCiT5z8oA9mC0uwDwBmlTIhWPyMbphVveybhOdk8ISfkVc6_KaVCgH5JThiVrBM935DrW3tnY7xvPM44eZxKMy-poCvhgI2tI01NGhtnowslTWFq7nDCdsFoC_pmxrkEj02lXIqhhPyavBhtzPjmcZ6Smy-ff15etdvvX79dXmxbJ4QqrRoZc2yEETRIB-BsP_Scw8CRSyvo4Do1DgPjSsvB-lFx6KQaUNtBK-ctPyVn691fNpp5CTu73Jtkg7m62JrjjnYSBDBxYJV9v7L1tz97zMXsQnYYo50w7bORUGtAdxXsV9AtKecFx6fLjJqjd_Pg3RylGgDz4N3omnv3WLAfduj_Sa2iK_BpBbAqOQRcTHYBJ4c-LFW28Sn8p-Iv7AOSyA</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>Mazelin, Ludmilla</creator><creator>Theodorou, Vassilia</creator><creator>Fioramonti, Jean</creator><creator>Bueno, Lionel</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>19991101</creationdate><title>Vagally dependent protective action of calcitonin gene-related peptide on colitis</title><author>Mazelin, Ludmilla ; Theodorou, Vassilia ; Fioramonti, Jean ; Bueno, Lionel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-7f11c1f9f9896c99ca5b5339b3e36a40bc27fbb13786badf739267be8ab87cda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Calcitonin Gene-Related Peptide - administration & dosage</topic><topic>Calcitonin Gene-Related Peptide - therapeutic use</topic><topic>CGRP</topic><topic>Colitis - drug therapy</topic><topic>Colitis - pathology</topic><topic>Gut inflammation</topic><topic>Injections, Intraventricular</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Myeloperoxidase</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>TNBS colitis</topic><topic>Trinitrobenzenesulfonic Acid - administration & dosage</topic><topic>Vagotomy</topic><topic>Vagus nerve</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mazelin, Ludmilla</creatorcontrib><creatorcontrib>Theodorou, Vassilia</creatorcontrib><creatorcontrib>Fioramonti, Jean</creatorcontrib><creatorcontrib>Bueno, Lionel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mazelin, Ludmilla</au><au>Theodorou, Vassilia</au><au>Fioramonti, Jean</au><au>Bueno, Lionel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vagally dependent protective action of calcitonin gene-related peptide on colitis</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>20</volume><issue>11</issue><spage>1367</spage><epage>1374</epage><pages>1367-1374</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><abstract>This work evaluates the mechanism of action of calcitonin gene-related peptide (CGRP) on colitis. 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| fulltext | fulltext |
| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 1999-11, Vol.20 (11), p.1367-1374 |
| issn | 0196-9781 1873-5169 |
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| subjects | Animals Calcitonin Gene-Related Peptide - administration & dosage Calcitonin Gene-Related Peptide - therapeutic use CGRP Colitis - drug therapy Colitis - pathology Gut inflammation Injections, Intraventricular Life Sciences Male Myeloperoxidase Rats Rats, Wistar TNBS colitis Trinitrobenzenesulfonic Acid - administration & dosage Vagotomy Vagus nerve |
| title | Vagally dependent protective action of calcitonin gene-related peptide on colitis |
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