Variations in digestive physiology of rats after short duration flights aboard the US space shuttle
The purpose of this work was to assess the influence of microgravity on several endogenous and microbial parameters of digestive physiology. On the occasion of two Spacelab Life Sciences missions, SLS-1 (a 9-day space flight) and SLS-2 (a 14-day space flight), Sprague-Dawley rats flown aboard the US...
Gespeichert in:
| Veröffentlicht in: | Digestive diseases and sciences 2000-09, Vol.45 (9), p.1687-1695 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1695 |
|---|---|
| container_issue | 9 |
| container_start_page | 1687 |
| container_title | Digestive diseases and sciences |
| container_volume | 45 |
| creator | Rabot, S Szylit, O Nugon-Baudon, L Meslin, J C Vaissade, P Popot, F Viso, M |
| description | The purpose of this work was to assess the influence of microgravity on several endogenous and microbial parameters of digestive physiology. On the occasion of two Spacelab Life Sciences missions, SLS-1 (a 9-day space flight) and SLS-2 (a 14-day space flight), Sprague-Dawley rats flown aboard the US space shuttle were compared to age-matched ground-based controls. In both flights, exposure to microgravity modified cecal fermentation: concentration and profile of short-chain fatty acids were altered, whereas urea and ammonia remained unchanged. Only in SLS-1 was there an induction of intestinal glutathione-S-transferase. Additional analyses in SLS-2 showed a decrease of hepatic CYP450 and of colonic goblet cells containing neutral mucin. After a postflight recovery period equal to the mission length, only modifications of the hepatic and intestinal xenobiotic metabolizing enzymes still persisted. These findings should help to predict the alterations of digestive physiology and detoxification potential likely to occur in astronauts. Their possible influence on health is discussed. |
| doi_str_mv | 10.1023/A:1005508532629 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02694892v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72369130</sourcerecordid><originalsourceid>FETCH-LOGICAL-c314t-8c8e78ebeac96934453ca667db8da55bb62dd2d04acd8c0f6f547cdf9b27ab5f3</originalsourceid><addsrcrecordid>eNpd0DtPwzAQAGALgWh5zGzIYkBiCPgROzFbVQFFqsQAZY0c22lcpXGwnUr996S0MDD55PvuTncAXGF0jxGhD5NHjBBjKGeUcCKOwBizjCaE8fwYjBHmQ4wxH4GzEFYIIZFhfgpGGCNGKOJjoD6ltzJa1wZoW6jt0oRoNwZ29TZY17jlFroKehkDlFU0Hoba-Qh173-qYNXYZb1Llk56DWNt4OIdhk4qM9A-xsZcgJNKNsFcHt5zsHh--pjOkvnby-t0Mk8UxWlMcpWbLDelkUpwQdOUUSU5z3SZa8lYWXKiNdEolUrnClW8YmmmdCVKksmSVfQc3O371rIpOm_X0m8LJ20xm8yL3R8iXKS5IBs82Nu97bz76oedi7UNyjSNbI3rQ5ERygWmaIA3_-DK9b4d9igITikRKeEDuj6gvlwb_Tf89870G8sUf9Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>214329426</pqid></control><display><type>article</type><title>Variations in digestive physiology of rats after short duration flights aboard the US space shuttle</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Rabot, S ; Szylit, O ; Nugon-Baudon, L ; Meslin, J C ; Vaissade, P ; Popot, F ; Viso, M</creator><creatorcontrib>Rabot, S ; Szylit, O ; Nugon-Baudon, L ; Meslin, J C ; Vaissade, P ; Popot, F ; Viso, M</creatorcontrib><description>The purpose of this work was to assess the influence of microgravity on several endogenous and microbial parameters of digestive physiology. On the occasion of two Spacelab Life Sciences missions, SLS-1 (a 9-day space flight) and SLS-2 (a 14-day space flight), Sprague-Dawley rats flown aboard the US space shuttle were compared to age-matched ground-based controls. In both flights, exposure to microgravity modified cecal fermentation: concentration and profile of short-chain fatty acids were altered, whereas urea and ammonia remained unchanged. Only in SLS-1 was there an induction of intestinal glutathione-S-transferase. Additional analyses in SLS-2 showed a decrease of hepatic CYP450 and of colonic goblet cells containing neutral mucin. After a postflight recovery period equal to the mission length, only modifications of the hepatic and intestinal xenobiotic metabolizing enzymes still persisted. These findings should help to predict the alterations of digestive physiology and detoxification potential likely to occur in astronauts. Their possible influence on health is discussed.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1023/A:1005508532629</identifier><identifier>PMID: 11052306</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Cecum - metabolism ; Cytochrome P-450 Enzyme System - metabolism ; Fermentation ; Glutathione Transferase - metabolism ; Histamine - metabolism ; Histocytochemistry ; Intestinal Mucosa - cytology ; Intestinal Mucosa - metabolism ; Intestine, Small - metabolism ; Intestines - microbiology ; Life Sciences ; Liver - enzymology ; Male ; Mucins - metabolism ; Rats ; Rats, Sprague-Dawley ; Space Flight ; Space life sciences ; Weightlessness</subject><ispartof>Digestive diseases and sciences, 2000-09, Vol.45 (9), p.1687-1695</ispartof><rights>Copyright Kluwer Academic Publishers Sep 2000</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c314t-8c8e78ebeac96934453ca667db8da55bb62dd2d04acd8c0f6f547cdf9b27ab5f3</citedby><orcidid>0000-0002-4603-2038</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11052306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02694892$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Rabot, S</creatorcontrib><creatorcontrib>Szylit, O</creatorcontrib><creatorcontrib>Nugon-Baudon, L</creatorcontrib><creatorcontrib>Meslin, J C</creatorcontrib><creatorcontrib>Vaissade, P</creatorcontrib><creatorcontrib>Popot, F</creatorcontrib><creatorcontrib>Viso, M</creatorcontrib><title>Variations in digestive physiology of rats after short duration flights aboard the US space shuttle</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>The purpose of this work was to assess the influence of microgravity on several endogenous and microbial parameters of digestive physiology. On the occasion of two Spacelab Life Sciences missions, SLS-1 (a 9-day space flight) and SLS-2 (a 14-day space flight), Sprague-Dawley rats flown aboard the US space shuttle were compared to age-matched ground-based controls. In both flights, exposure to microgravity modified cecal fermentation: concentration and profile of short-chain fatty acids were altered, whereas urea and ammonia remained unchanged. Only in SLS-1 was there an induction of intestinal glutathione-S-transferase. Additional analyses in SLS-2 showed a decrease of hepatic CYP450 and of colonic goblet cells containing neutral mucin. After a postflight recovery period equal to the mission length, only modifications of the hepatic and intestinal xenobiotic metabolizing enzymes still persisted. These findings should help to predict the alterations of digestive physiology and detoxification potential likely to occur in astronauts. Their possible influence on health is discussed.</description><subject>Animals</subject><subject>Cecum - metabolism</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>Fermentation</subject><subject>Glutathione Transferase - metabolism</subject><subject>Histamine - metabolism</subject><subject>Histocytochemistry</subject><subject>Intestinal Mucosa - cytology</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestine, Small - metabolism</subject><subject>Intestines - microbiology</subject><subject>Life Sciences</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>Mucins - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Space Flight</subject><subject>Space life sciences</subject><subject>Weightlessness</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0DtPwzAQAGALgWh5zGzIYkBiCPgROzFbVQFFqsQAZY0c22lcpXGwnUr996S0MDD55PvuTncAXGF0jxGhD5NHjBBjKGeUcCKOwBizjCaE8fwYjBHmQ4wxH4GzEFYIIZFhfgpGGCNGKOJjoD6ltzJa1wZoW6jt0oRoNwZ29TZY17jlFroKehkDlFU0Hoba-Qh173-qYNXYZb1Llk56DWNt4OIdhk4qM9A-xsZcgJNKNsFcHt5zsHh--pjOkvnby-t0Mk8UxWlMcpWbLDelkUpwQdOUUSU5z3SZa8lYWXKiNdEolUrnClW8YmmmdCVKksmSVfQc3O371rIpOm_X0m8LJ20xm8yL3R8iXKS5IBs82Nu97bz76oedi7UNyjSNbI3rQ5ERygWmaIA3_-DK9b4d9igITikRKeEDuj6gvlwb_Tf89870G8sUf9Q</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>Rabot, S</creator><creator>Szylit, O</creator><creator>Nugon-Baudon, L</creator><creator>Meslin, J C</creator><creator>Vaissade, P</creator><creator>Popot, F</creator><creator>Viso, M</creator><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-4603-2038</orcidid></search><sort><creationdate>20000901</creationdate><title>Variations in digestive physiology of rats after short duration flights aboard the US space shuttle</title><author>Rabot, S ; Szylit, O ; Nugon-Baudon, L ; Meslin, J C ; Vaissade, P ; Popot, F ; Viso, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-8c8e78ebeac96934453ca667db8da55bb62dd2d04acd8c0f6f547cdf9b27ab5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Cecum - metabolism</topic><topic>Cytochrome P-450 Enzyme System - metabolism</topic><topic>Fermentation</topic><topic>Glutathione Transferase - metabolism</topic><topic>Histamine - metabolism</topic><topic>Histocytochemistry</topic><topic>Intestinal Mucosa - cytology</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestine, Small - metabolism</topic><topic>Intestines - microbiology</topic><topic>Life Sciences</topic><topic>Liver - enzymology</topic><topic>Male</topic><topic>Mucins - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Space Flight</topic><topic>Space life sciences</topic><topic>Weightlessness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rabot, S</creatorcontrib><creatorcontrib>Szylit, O</creatorcontrib><creatorcontrib>Nugon-Baudon, L</creatorcontrib><creatorcontrib>Meslin, J C</creatorcontrib><creatorcontrib>Vaissade, P</creatorcontrib><creatorcontrib>Popot, F</creatorcontrib><creatorcontrib>Viso, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rabot, S</au><au>Szylit, O</au><au>Nugon-Baudon, L</au><au>Meslin, J C</au><au>Vaissade, P</au><au>Popot, F</au><au>Viso, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variations in digestive physiology of rats after short duration flights aboard the US space shuttle</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>2000-09-01</date><risdate>2000</risdate><volume>45</volume><issue>9</issue><spage>1687</spage><epage>1695</epage><pages>1687-1695</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>The purpose of this work was to assess the influence of microgravity on several endogenous and microbial parameters of digestive physiology. On the occasion of two Spacelab Life Sciences missions, SLS-1 (a 9-day space flight) and SLS-2 (a 14-day space flight), Sprague-Dawley rats flown aboard the US space shuttle were compared to age-matched ground-based controls. In both flights, exposure to microgravity modified cecal fermentation: concentration and profile of short-chain fatty acids were altered, whereas urea and ammonia remained unchanged. Only in SLS-1 was there an induction of intestinal glutathione-S-transferase. Additional analyses in SLS-2 showed a decrease of hepatic CYP450 and of colonic goblet cells containing neutral mucin. After a postflight recovery period equal to the mission length, only modifications of the hepatic and intestinal xenobiotic metabolizing enzymes still persisted. These findings should help to predict the alterations of digestive physiology and detoxification potential likely to occur in astronauts. Their possible influence on health is discussed.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>11052306</pmid><doi>10.1023/A:1005508532629</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-4603-2038</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 2000-09, Vol.45 (9), p.1687-1695 |
| issn | 0163-2116 1573-2568 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02694892v1 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Cecum - metabolism Cytochrome P-450 Enzyme System - metabolism Fermentation Glutathione Transferase - metabolism Histamine - metabolism Histocytochemistry Intestinal Mucosa - cytology Intestinal Mucosa - metabolism Intestine, Small - metabolism Intestines - microbiology Life Sciences Liver - enzymology Male Mucins - metabolism Rats Rats, Sprague-Dawley Space Flight Space life sciences Weightlessness |
| title | Variations in digestive physiology of rats after short duration flights aboard the US space shuttle |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T04%3A49%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Variations%20in%20digestive%20physiology%20of%20rats%20after%20short%20duration%20flights%20aboard%20the%20US%20space%20shuttle&rft.jtitle=Digestive%20diseases%20and%20sciences&rft.au=Rabot,%20S&rft.date=2000-09-01&rft.volume=45&rft.issue=9&rft.spage=1687&rft.epage=1695&rft.pages=1687-1695&rft.issn=0163-2116&rft.eissn=1573-2568&rft.coden=DDSCDJ&rft_id=info:doi/10.1023/A:1005508532629&rft_dat=%3Cproquest_hal_p%3E72369130%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=214329426&rft_id=info:pmid/11052306&rfr_iscdi=true |