Exacerbated immune stress response during experimental magnesium deficiency results from abnormal cell calcium homeostasis
The aim of this study was to assess the potential mechanism underlying the enhanced inflammatory processes during magnesium deficit. In this study, exacerbated response to live bacteria and platelet activating factors was shown in rats fed a magnesium-deficient diet. Peritoneal cells from these anim...
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| Veröffentlicht in: | Life sciences (1973) 1998, Vol.63 (20), p.1815-1822 |
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| container_end_page | 1822 |
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| container_issue | 20 |
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| container_title | Life sciences (1973) |
| container_volume | 63 |
| creator | Malpuech-Brugère, Corinne Rock, Edmond Astier, Catherine Nowacki, Wojciech Mazur, Andrzej Rayssiguier, Yves |
| description | The aim of this study was to assess the potential mechanism underlying the enhanced inflammatory processes during magnesium deficit. In this study, exacerbated response to live bacteria and platelet activating factors was shown in rats fed a magnesium-deficient diet. Peritoneal cells from these animals also showed enhanced Superoxide anion production and calcium mobilising potency following in vitro stimulation. The latter effect occurred very early in the course of magnesium deficiency. These studies first showed that an abnormal calcium handling induced by extracellular magnesium depression in vivo may be at the origin of exacerbated inflammatory response. |
| doi_str_mv | 10.1016/S0024-3205(98)00455-X |
| format | Article |
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In this study, exacerbated response to live bacteria and platelet activating factors was shown in rats fed a magnesium-deficient diet. Peritoneal cells from these animals also showed enhanced Superoxide anion production and calcium mobilising potency following in vitro stimulation. The latter effect occurred very early in the course of magnesium deficiency. These studies first showed that an abnormal calcium handling induced by extracellular magnesium depression in vivo may be at the origin of exacerbated inflammatory response.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/S0024-3205(98)00455-X</identifier><identifier>PMID: 9820125</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Antigens, Bacterial - immunology ; Calcium - immunology ; Calcium - metabolism ; calcium homeostasis ; Escherichia coli - immunology ; immune stress ; Immunity ; Life Sciences ; Macrophages, Peritoneal - immunology ; Magnesium Deficiency - immunology ; Magnesium Deficiency - metabolism ; magnesium deficit ; Male ; Platelet Activating Factor - immunology ; Rats ; Rats, Wistar ; Respiratory Burst ; Superoxides - immunology ; Superoxides - metabolism</subject><ispartof>Life sciences (1973), 1998, Vol.63 (20), p.1815-1822</ispartof><rights>1998</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-e2ac5c40b7f85b0bbfbcb4da42f8296111016206a4908886dc64f89633b351503</citedby><cites>FETCH-LOGICAL-c394t-e2ac5c40b7f85b0bbfbcb4da42f8296111016206a4908886dc64f89633b351503</cites><orcidid>0000-0002-1067-5066</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0024-3205(98)00455-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9820125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02693614$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Malpuech-Brugère, Corinne</creatorcontrib><creatorcontrib>Rock, Edmond</creatorcontrib><creatorcontrib>Astier, Catherine</creatorcontrib><creatorcontrib>Nowacki, Wojciech</creatorcontrib><creatorcontrib>Mazur, Andrzej</creatorcontrib><creatorcontrib>Rayssiguier, Yves</creatorcontrib><title>Exacerbated immune stress response during experimental magnesium deficiency results from abnormal cell calcium homeostasis</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>The aim of this study was to assess the potential mechanism underlying the enhanced inflammatory processes during magnesium deficit. In this study, exacerbated response to live bacteria and platelet activating factors was shown in rats fed a magnesium-deficient diet. Peritoneal cells from these animals also showed enhanced Superoxide anion production and calcium mobilising potency following in vitro stimulation. The latter effect occurred very early in the course of magnesium deficiency. These studies first showed that an abnormal calcium handling induced by extracellular magnesium depression in vivo may be at the origin of exacerbated inflammatory response.</description><subject>Animals</subject><subject>Antigens, Bacterial - immunology</subject><subject>Calcium - immunology</subject><subject>Calcium - metabolism</subject><subject>calcium homeostasis</subject><subject>Escherichia coli - immunology</subject><subject>immune stress</subject><subject>Immunity</subject><subject>Life Sciences</subject><subject>Macrophages, Peritoneal - immunology</subject><subject>Magnesium Deficiency - immunology</subject><subject>Magnesium Deficiency - metabolism</subject><subject>magnesium deficit</subject><subject>Male</subject><subject>Platelet Activating Factor - immunology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Respiratory Burst</subject><subject>Superoxides - immunology</subject><subject>Superoxides - metabolism</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVoSbdJfkLAp9Ic3I4sSyudSghpU1jooS3kJiR5nChY1layQ9JfX3l32WsvI9A88_W-hFxS-ESBis8_AZq2Zg3wj0peAbSc1_cnZEXlWtUgGH1DVkfkHXmf8xMAcL5mp-RUyQZow1fk7-2LcZismbCrfAjziFWeEuZclbCNY8aqm5MfHyp82WLyAcfJDFUwDyNmP4eqw947j6N7XSrmYcpVn2KojB1jCgV1OJRgBrfQjzFgzJPJPp-Tt70ZMl4c3jPy--vtr5u7evPj2_eb603tmGqnGhvjuGvBrnvJLVjbW2fbzrRNLxslKF3UaECYVoGUUnROtL1UgjHLOOXAzsjVvu-jGfS2XGDSq47G67vrjV7-oBGKCdo-08J-2LPbFP_MmCcdfF4OMCPGOet1UVAwIQvI96BLMeeE_bEzBb1spHf-6EV8raTe-aPvS93lYcBsA3bHqoMhJf9ln8eiyLPHpPNOXOx8QjfpLvr_TPgHsj2hsg</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Malpuech-Brugère, Corinne</creator><creator>Rock, Edmond</creator><creator>Astier, Catherine</creator><creator>Nowacki, Wojciech</creator><creator>Mazur, Andrzej</creator><creator>Rayssiguier, Yves</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-1067-5066</orcidid></search><sort><creationdate>1998</creationdate><title>Exacerbated immune stress response during experimental magnesium deficiency results from abnormal cell calcium homeostasis</title><author>Malpuech-Brugère, Corinne ; Rock, Edmond ; Astier, Catherine ; Nowacki, Wojciech ; Mazur, Andrzej ; Rayssiguier, Yves</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-e2ac5c40b7f85b0bbfbcb4da42f8296111016206a4908886dc64f89633b351503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Antigens, Bacterial - immunology</topic><topic>Calcium - immunology</topic><topic>Calcium - metabolism</topic><topic>calcium homeostasis</topic><topic>Escherichia coli - immunology</topic><topic>immune stress</topic><topic>Immunity</topic><topic>Life Sciences</topic><topic>Macrophages, Peritoneal - immunology</topic><topic>Magnesium Deficiency - immunology</topic><topic>Magnesium Deficiency - metabolism</topic><topic>magnesium deficit</topic><topic>Male</topic><topic>Platelet Activating Factor - immunology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Respiratory Burst</topic><topic>Superoxides - immunology</topic><topic>Superoxides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malpuech-Brugère, Corinne</creatorcontrib><creatorcontrib>Rock, Edmond</creatorcontrib><creatorcontrib>Astier, Catherine</creatorcontrib><creatorcontrib>Nowacki, Wojciech</creatorcontrib><creatorcontrib>Mazur, Andrzej</creatorcontrib><creatorcontrib>Rayssiguier, Yves</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malpuech-Brugère, Corinne</au><au>Rock, Edmond</au><au>Astier, Catherine</au><au>Nowacki, Wojciech</au><au>Mazur, Andrzej</au><au>Rayssiguier, Yves</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exacerbated immune stress response during experimental magnesium deficiency results from abnormal cell calcium homeostasis</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1998</date><risdate>1998</risdate><volume>63</volume><issue>20</issue><spage>1815</spage><epage>1822</epage><pages>1815-1822</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>The aim of this study was to assess the potential mechanism underlying the enhanced inflammatory processes during magnesium deficit. In this study, exacerbated response to live bacteria and platelet activating factors was shown in rats fed a magnesium-deficient diet. Peritoneal cells from these animals also showed enhanced Superoxide anion production and calcium mobilising potency following in vitro stimulation. The latter effect occurred very early in the course of magnesium deficiency. These studies first showed that an abnormal calcium handling induced by extracellular magnesium depression in vivo may be at the origin of exacerbated inflammatory response.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>9820125</pmid><doi>10.1016/S0024-3205(98)00455-X</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1067-5066</orcidid></addata></record> |
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| ispartof | Life sciences (1973), 1998, Vol.63 (20), p.1815-1822 |
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| subjects | Animals Antigens, Bacterial - immunology Calcium - immunology Calcium - metabolism calcium homeostasis Escherichia coli - immunology immune stress Immunity Life Sciences Macrophages, Peritoneal - immunology Magnesium Deficiency - immunology Magnesium Deficiency - metabolism magnesium deficit Male Platelet Activating Factor - immunology Rats Rats, Wistar Respiratory Burst Superoxides - immunology Superoxides - metabolism |
| title | Exacerbated immune stress response during experimental magnesium deficiency results from abnormal cell calcium homeostasis |
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