Modulation of Pituitary Dopamine D1 or D2 Receptors and Secretion of Follicle Stimulating Hormone and Luteinizing Hormone During the Annual Reproductive Cycle of Female Rainbow Trout

The two gonadotrophins follicle stimulating hormone (FSH) and luteinizing hormone (LH) have distinct temporal expression and release profiles in fish, but little is known regarding their neuroendocrine control, especially for FSH. The present experiments were performed on previtellogenic, mature and...

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Veröffentlicht in:Journal of neuroendocrinology 2000-12, Vol.12 (12), p.1219-1226
Hauptverfasser: Vacher, C., Mañanos, E. L., Breton, B., Marmignon, M.-H., Saligaut, C.
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container_issue 12
container_start_page 1219
container_title Journal of neuroendocrinology
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creator Vacher, C.
Mañanos, E. L.
Breton, B.
Marmignon, M.-H.
Saligaut, C.
description The two gonadotrophins follicle stimulating hormone (FSH) and luteinizing hormone (LH) have distinct temporal expression and release profiles in fish, but little is known regarding their neuroendocrine control, especially for FSH. The present experiments were performed on previtellogenic, mature and preovulatory female trout. The catecholamine synthesis inhibitor, α‐methyl‐p‐tyrosine, increased plasma LH and FSH concentrations of mature fish. The dopamine agonist apomorphine decreased and the dopamine antagonist domperidone increased plasma LH concentration of preovulatory fish and delayed ovulation, but did not modify plasma FSH concentration. The dopamine D2 agonist bromocryptine inhibited LH release in cultured gonadotrophs from mature and preovulatory fish, but not from previtellogenic fish. Bromocryptine also significantly inhibited basal and salmon gonadotrophin releasing‐hormone (sGnRH)‐induced FSH release from cultured gonadotrophs of mature fish, but not of preovulatory fish, and increased FSH release from gonadotrophs of previtellogenic fish. The dopamine D1 agonist SKF 38393 had no observed effect on the release of FSH and LH, at any reproductive stage studied. The D1 agonist SKF 38393, the D2 agonist bromocriptine and sGnRH had no observed effects on cell contents of FSH and LH. Taken together, these data suggest that, at the level of the pituitary, dopamine inhibits LH release as vitellogenesis proceeds, via activation of dopamine D2 receptors. We demonstrate for the first time in fish a control of FSH release (a dopamine control), especially in mature fish which have low circulating concentrations of FSH.
doi_str_mv 10.1046/j.1365-2826.2000.00585.x
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L. ; Breton, B. ; Marmignon, M.-H. ; Saligaut, C.</creator><creatorcontrib>Vacher, C. ; Mañanos, E. L. ; Breton, B. ; Marmignon, M.-H. ; Saligaut, C.</creatorcontrib><description>The two gonadotrophins follicle stimulating hormone (FSH) and luteinizing hormone (LH) have distinct temporal expression and release profiles in fish, but little is known regarding their neuroendocrine control, especially for FSH. The present experiments were performed on previtellogenic, mature and preovulatory female trout. The catecholamine synthesis inhibitor, α‐methyl‐p‐tyrosine, increased plasma LH and FSH concentrations of mature fish. The dopamine agonist apomorphine decreased and the dopamine antagonist domperidone increased plasma LH concentration of preovulatory fish and delayed ovulation, but did not modify plasma FSH concentration. The dopamine D2 agonist bromocryptine inhibited LH release in cultured gonadotrophs from mature and preovulatory fish, but not from previtellogenic fish. Bromocryptine also significantly inhibited basal and salmon gonadotrophin releasing‐hormone (sGnRH)‐induced FSH release from cultured gonadotrophs of mature fish, but not of preovulatory fish, and increased FSH release from gonadotrophs of previtellogenic fish. The dopamine D1 agonist SKF 38393 had no observed effect on the release of FSH and LH, at any reproductive stage studied. The D1 agonist SKF 38393, the D2 agonist bromocriptine and sGnRH had no observed effects on cell contents of FSH and LH. Taken together, these data suggest that, at the level of the pituitary, dopamine inhibits LH release as vitellogenesis proceeds, via activation of dopamine D2 receptors. 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L.</creatorcontrib><creatorcontrib>Breton, B.</creatorcontrib><creatorcontrib>Marmignon, M.-H.</creatorcontrib><creatorcontrib>Saligaut, C.</creatorcontrib><title>Modulation of Pituitary Dopamine D1 or D2 Receptors and Secretion of Follicle Stimulating Hormone and Luteinizing Hormone During the Annual Reproductive Cycle of Female Rainbow Trout</title><title>Journal of neuroendocrinology</title><addtitle>J Neuroendocrinol</addtitle><description>The two gonadotrophins follicle stimulating hormone (FSH) and luteinizing hormone (LH) have distinct temporal expression and release profiles in fish, but little is known regarding their neuroendocrine control, especially for FSH. The present experiments were performed on previtellogenic, mature and preovulatory female trout. The catecholamine synthesis inhibitor, α‐methyl‐p‐tyrosine, increased plasma LH and FSH concentrations of mature fish. The dopamine agonist apomorphine decreased and the dopamine antagonist domperidone increased plasma LH concentration of preovulatory fish and delayed ovulation, but did not modify plasma FSH concentration. The dopamine D2 agonist bromocryptine inhibited LH release in cultured gonadotrophs from mature and preovulatory fish, but not from previtellogenic fish. Bromocryptine also significantly inhibited basal and salmon gonadotrophin releasing‐hormone (sGnRH)‐induced FSH release from cultured gonadotrophs of mature fish, but not of preovulatory fish, and increased FSH release from gonadotrophs of previtellogenic fish. The dopamine D1 agonist SKF 38393 had no observed effect on the release of FSH and LH, at any reproductive stage studied. The D1 agonist SKF 38393, the D2 agonist bromocriptine and sGnRH had no observed effects on cell contents of FSH and LH. Taken together, these data suggest that, at the level of the pituitary, dopamine inhibits LH release as vitellogenesis proceeds, via activation of dopamine D2 receptors. 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L.</creatorcontrib><creatorcontrib>Breton, B.</creatorcontrib><creatorcontrib>Marmignon, M.-H.</creatorcontrib><creatorcontrib>Saligaut, C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science &amp; Fisheries Abstracts (ASFA) 1: Biological Sciences &amp; Living Resources</collection><collection>Aquatic Science &amp; Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of neuroendocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vacher, C.</au><au>Mañanos, E. L.</au><au>Breton, B.</au><au>Marmignon, M.-H.</au><au>Saligaut, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of Pituitary Dopamine D1 or D2 Receptors and Secretion of Follicle Stimulating Hormone and Luteinizing Hormone During the Annual Reproductive Cycle of Female Rainbow Trout</atitle><jtitle>Journal of neuroendocrinology</jtitle><addtitle>J Neuroendocrinol</addtitle><date>2000-12</date><risdate>2000</risdate><volume>12</volume><issue>12</issue><spage>1219</spage><epage>1226</epage><pages>1219-1226</pages><issn>0953-8194</issn><eissn>1365-2826</eissn><abstract>The two gonadotrophins follicle stimulating hormone (FSH) and luteinizing hormone (LH) have distinct temporal expression and release profiles in fish, but little is known regarding their neuroendocrine control, especially for FSH. The present experiments were performed on previtellogenic, mature and preovulatory female trout. The catecholamine synthesis inhibitor, α‐methyl‐p‐tyrosine, increased plasma LH and FSH concentrations of mature fish. The dopamine agonist apomorphine decreased and the dopamine antagonist domperidone increased plasma LH concentration of preovulatory fish and delayed ovulation, but did not modify plasma FSH concentration. The dopamine D2 agonist bromocryptine inhibited LH release in cultured gonadotrophs from mature and preovulatory fish, but not from previtellogenic fish. Bromocryptine also significantly inhibited basal and salmon gonadotrophin releasing‐hormone (sGnRH)‐induced FSH release from cultured gonadotrophs of mature fish, but not of preovulatory fish, and increased FSH release from gonadotrophs of previtellogenic fish. The dopamine D1 agonist SKF 38393 had no observed effect on the release of FSH and LH, at any reproductive stage studied. The D1 agonist SKF 38393, the D2 agonist bromocriptine and sGnRH had no observed effects on cell contents of FSH and LH. Taken together, these data suggest that, at the level of the pituitary, dopamine inhibits LH release as vitellogenesis proceeds, via activation of dopamine D2 receptors. We demonstrate for the first time in fish a control of FSH release (a dopamine control), especially in mature fish which have low circulating concentrations of FSH.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11106981</pmid><doi>10.1046/j.1365-2826.2000.00585.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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identifier ISSN: 0953-8194
ispartof Journal of neuroendocrinology, 2000-12, Vol.12 (12), p.1219-1226
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subjects 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology
Age Factors
Animals
Bromocriptine - pharmacology
Cells, Cultured
dopamine
Dopamine Agonists - pharmacology
Female
Fertility Agents, Female - pharmacology
fish
Follicle Stimulating Hormone - blood
Follicle Stimulating Hormone - secretion
Follicular Phase - drug effects
Follicular Phase - physiology
Freshwater
gonadotrophins
Gonadotropin-Releasing Hormone - pharmacology
In Vitro Techniques
Life Sciences
Luteinizing Hormone - blood
Luteinizing Hormone - secretion
Neurons and Cognition
neurotransmitters
Oncorhynchus mykiss
Oncorhynchus mykiss - physiology
Pisces
pituitary
Pituitary Gland - cytology
Pituitary Gland - metabolism
Pituitary Gland - secretion
rainbow trout
Receptors, Dopamine D1 - agonists
Receptors, Dopamine D1 - metabolism
Receptors, Dopamine D2 - agonists
Receptors, Dopamine D2 - metabolism
reproduction
Salmonidae
Sexual Maturation - physiology
title Modulation of Pituitary Dopamine D1 or D2 Receptors and Secretion of Follicle Stimulating Hormone and Luteinizing Hormone During the Annual Reproductive Cycle of Female Rainbow Trout
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