Major involvement of rabbit liver cytochrome P4501A in thiabendazole 5-hydroxylation

1. Thiabendazole is a widely used food preservative and anthelmintic drug for breeding animal species. In order to characterize precisely the cytochrome P450 isozyme(s) involved in its major route of metabolism, a rapid and sensitive spectrofluorimetric method was developed for the simultaneous dete...

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Veröffentlicht in:	Xenobiotica 1996, Vol.26 (7), p.765-778
Hauptverfasser:	Rey-Grobellet, X, Eeckhoutte, C, Sutra, J.F, Alvinerie, M, Galtier, P
Format:	Artikel
Sprache:	eng
Schlagworte:	5-hydroxythiabendazole Animals Antinematodal Agents - metabolism Biodiversity Biological and medical sciences Blotting, Western cytochrome P-450 Cytochrome P-450 CYP1A1 - antagonists & inhibitors Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 CYP1A2 - metabolism Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP2B1 - metabolism enzyme activity Enzyme Inhibitors - pharmacology Hydroxylation isozymes Kinetics Life Sciences liver Male Medical sciences metabolism metabolites microsomes Microsomes, Liver - enzymology Pesticides, fertilizers and other agrochemicals toxicology Rabbits Spectrometry, Fluorescence thiabendazole Thiabendazole - metabolism Toxicology unspecific monooxygenase
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