The ovine SOX2 gene: sequence, chromosomal localization and gonadal expression
The SOX gene family consists of a large number of embryonically expressed genes capable of encoding putative transcription factors and related by a DNA-binding domain, the HMG-box. We cloned and characterized the ovine SOX2 transcript using the screening of a testis (12d pp) cDNA library with a prob...
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| Veröffentlicht in: | Gene 1997-04, Vol.189 (1), p.143-147 |
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| container_title | Gene |
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| creator | Payen, Emmanuel Pailhoux, Eric Gianquinto, Laurence Hayes, Helène Le Pennec, Nathalie Bezard, Jacqueline Cotinot, Corinne |
| description | The
SOX gene family consists of a large number of embryonically expressed genes capable of encoding putative transcription factors and related by a DNA-binding domain, the HMG-box. We cloned and characterized the ovine
SOX2 transcript using the screening of a testis (12d
pp) cDNA library with a probe containing the SRY-HMG-box and we performed 3′RACE experiments. The ovine
SOX2 sequence is strongly conserved in comparison to the human, mouse and chicken homologues and is located on sheep chromosome 1q33. The
SOX2 expression pattern in developing gonads is consistent with the hypothesis that this gene plays a role in the germ cell line.
© 1997 Elsevier Science B.V. All rights reserved. |
| doi_str_mv | 10.1016/S0378-1119(96)00782-2 |
| format | Article |
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SOX gene family consists of a large number of embryonically expressed genes capable of encoding putative transcription factors and related by a DNA-binding domain, the HMG-box. We cloned and characterized the ovine
SOX2 transcript using the screening of a testis (12d
pp) cDNA library with a probe containing the SRY-HMG-box and we performed 3′RACE experiments. The ovine
SOX2 sequence is strongly conserved in comparison to the human, mouse and chicken homologues and is located on sheep chromosome 1q33. The
SOX2 expression pattern in developing gonads is consistent with the hypothesis that this gene plays a role in the germ cell line.
© 1997 Elsevier Science B.V. All rights reserved.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/S0378-1119(96)00782-2</identifier><identifier>PMID: 9161426</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Amino Acid Sequence ; amino acid sequences ; Animals ; Base Sequence ; Chromosome Mapping ; chromosomes ; Cloning, Molecular ; complementary DNA ; Developmental expression ; DNA-Binding Proteins - chemistry ; DNA-Binding Proteins - genetics ; genbank/x96997 ; gene expression ; Gene Expression Regulation, Developmental ; gene location ; Genes ; Genetics ; gonads ; Gonads - metabolism ; HMGB Proteins ; Life Sciences ; Male ; messenger RNA ; Molecular Sequence Data ; Nuclear Proteins - chemistry ; Nuclear Proteins - genetics ; Nucleotide sequence ; nucleotide sequences ; Ovis aries ; regulator genes ; Sheep ; Sox genes ; SOXB1 Transcription Factors ; Testis - metabolism ; Transcription Factors</subject><ispartof>Gene, 1997-04, Vol.189 (1), p.143-147</ispartof><rights>1996</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-2334dae149c1d6e3df0ba3b732473d78640c5098b14706a4ecae9592721132623</citedby><cites>FETCH-LOGICAL-c449t-2334dae149c1d6e3df0ba3b732473d78640c5098b14706a4ecae9592721132623</cites><orcidid>0000-0002-5442-2626 ; 0000-0001-8012-9143</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0378-1119(96)00782-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9161426$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02691973$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Payen, Emmanuel</creatorcontrib><creatorcontrib>Pailhoux, Eric</creatorcontrib><creatorcontrib>Gianquinto, Laurence</creatorcontrib><creatorcontrib>Hayes, Helène</creatorcontrib><creatorcontrib>Le Pennec, Nathalie</creatorcontrib><creatorcontrib>Bezard, Jacqueline</creatorcontrib><creatorcontrib>Cotinot, Corinne</creatorcontrib><title>The ovine SOX2 gene: sequence, chromosomal localization and gonadal expression</title><title>Gene</title><addtitle>Gene</addtitle><description>The
SOX gene family consists of a large number of embryonically expressed genes capable of encoding putative transcription factors and related by a DNA-binding domain, the HMG-box. We cloned and characterized the ovine
SOX2 transcript using the screening of a testis (12d
pp) cDNA library with a probe containing the SRY-HMG-box and we performed 3′RACE experiments. The ovine
SOX2 sequence is strongly conserved in comparison to the human, mouse and chicken homologues and is located on sheep chromosome 1q33. The
SOX2 expression pattern in developing gonads is consistent with the hypothesis that this gene plays a role in the germ cell line.
© 1997 Elsevier Science B.V. All rights reserved.</description><subject>Amino Acid Sequence</subject><subject>amino acid sequences</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Chromosome Mapping</subject><subject>chromosomes</subject><subject>Cloning, Molecular</subject><subject>complementary DNA</subject><subject>Developmental expression</subject><subject>DNA-Binding Proteins - chemistry</subject><subject>DNA-Binding Proteins - genetics</subject><subject>genbank/x96997</subject><subject>gene expression</subject><subject>Gene Expression Regulation, Developmental</subject><subject>gene location</subject><subject>Genes</subject><subject>Genetics</subject><subject>gonads</subject><subject>Gonads - metabolism</subject><subject>HMGB Proteins</subject><subject>Life Sciences</subject><subject>Male</subject><subject>messenger RNA</subject><subject>Molecular Sequence Data</subject><subject>Nuclear Proteins - chemistry</subject><subject>Nuclear Proteins - genetics</subject><subject>Nucleotide sequence</subject><subject>nucleotide sequences</subject><subject>Ovis aries</subject><subject>regulator genes</subject><subject>Sheep</subject><subject>Sox genes</subject><subject>SOXB1 Transcription Factors</subject><subject>Testis - metabolism</subject><subject>Transcription Factors</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uEzEUhS0EKqHwCBWzQlRiwNee8Q8bVFVAkSK6SCuxsxz7JjGaGad2EgFPj6cTZVtvLN3z2T4-h5ALoB-Bgvi0oFyqGgD0ey0uKZWK1ewZmYGSuqaUq-dkdkJeklc5_6ZltS07I2caBDRMzMjPuw1W8RAGrBa3v1i1xgE_Vxkf9jg4_FC5TYp9zLG3XdVFZ7vwz-5CHCo7-GodB-uLgH-2CXMu49fkxcp2Gd8c93Ny_-3r3fVNPb_9_uP6al67ptG7mnHeeIvQaAdeIPcrurR8KTlrJPdSiYa6lmq1hEZSYRt0FnWrmWQAnAnGz8nldO_GdmabQm_TXxNtMDdXczPOKBMatOQHKOy7id2mWL6Vd6YP2WHX2QHjPhupKeMlsCdBaJWSSrcFbCfQpZhzwtXJAlAzlmMeyzFj8kYL81iOGV1fHB_YL3v0p1PHNor-dtJXNhq7TiGb-wWjwClTQglJC_FlIrCEewiYTHZhbMqHhG5nfAxPePgPZlGlBw</recordid><startdate>19970411</startdate><enddate>19970411</enddate><creator>Payen, Emmanuel</creator><creator>Pailhoux, Eric</creator><creator>Gianquinto, Laurence</creator><creator>Hayes, Helène</creator><creator>Le Pennec, Nathalie</creator><creator>Bezard, Jacqueline</creator><creator>Cotinot, Corinne</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-5442-2626</orcidid><orcidid>https://orcid.org/0000-0001-8012-9143</orcidid></search><sort><creationdate>19970411</creationdate><title>The ovine SOX2 gene: sequence, chromosomal localization and gonadal expression</title><author>Payen, Emmanuel ; Pailhoux, Eric ; Gianquinto, Laurence ; Hayes, Helène ; Le Pennec, Nathalie ; Bezard, Jacqueline ; Cotinot, Corinne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-2334dae149c1d6e3df0ba3b732473d78640c5098b14706a4ecae9592721132623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Amino Acid Sequence</topic><topic>amino acid sequences</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Chromosome Mapping</topic><topic>chromosomes</topic><topic>Cloning, Molecular</topic><topic>complementary DNA</topic><topic>Developmental expression</topic><topic>DNA-Binding Proteins - chemistry</topic><topic>DNA-Binding Proteins - genetics</topic><topic>genbank/x96997</topic><topic>gene expression</topic><topic>Gene Expression Regulation, Developmental</topic><topic>gene location</topic><topic>Genes</topic><topic>Genetics</topic><topic>gonads</topic><topic>Gonads - metabolism</topic><topic>HMGB Proteins</topic><topic>Life Sciences</topic><topic>Male</topic><topic>messenger RNA</topic><topic>Molecular Sequence Data</topic><topic>Nuclear Proteins - chemistry</topic><topic>Nuclear Proteins - genetics</topic><topic>Nucleotide sequence</topic><topic>nucleotide sequences</topic><topic>Ovis aries</topic><topic>regulator genes</topic><topic>Sheep</topic><topic>Sox genes</topic><topic>SOXB1 Transcription Factors</topic><topic>Testis - metabolism</topic><topic>Transcription Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Payen, Emmanuel</creatorcontrib><creatorcontrib>Pailhoux, Eric</creatorcontrib><creatorcontrib>Gianquinto, Laurence</creatorcontrib><creatorcontrib>Hayes, Helène</creatorcontrib><creatorcontrib>Le Pennec, Nathalie</creatorcontrib><creatorcontrib>Bezard, Jacqueline</creatorcontrib><creatorcontrib>Cotinot, Corinne</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Payen, Emmanuel</au><au>Pailhoux, Eric</au><au>Gianquinto, Laurence</au><au>Hayes, Helène</au><au>Le Pennec, Nathalie</au><au>Bezard, Jacqueline</au><au>Cotinot, Corinne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The ovine SOX2 gene: sequence, chromosomal localization and gonadal expression</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>1997-04-11</date><risdate>1997</risdate><volume>189</volume><issue>1</issue><spage>143</spage><epage>147</epage><pages>143-147</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>The
SOX gene family consists of a large number of embryonically expressed genes capable of encoding putative transcription factors and related by a DNA-binding domain, the HMG-box. We cloned and characterized the ovine
SOX2 transcript using the screening of a testis (12d
pp) cDNA library with a probe containing the SRY-HMG-box and we performed 3′RACE experiments. The ovine
SOX2 sequence is strongly conserved in comparison to the human, mouse and chicken homologues and is located on sheep chromosome 1q33. The
SOX2 expression pattern in developing gonads is consistent with the hypothesis that this gene plays a role in the germ cell line.
© 1997 Elsevier Science B.V. All rights reserved.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>9161426</pmid><doi>10.1016/S0378-1119(96)00782-2</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-5442-2626</orcidid><orcidid>https://orcid.org/0000-0001-8012-9143</orcidid></addata></record> |
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| ispartof | Gene, 1997-04, Vol.189 (1), p.143-147 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acid Sequence amino acid sequences Animals Base Sequence Chromosome Mapping chromosomes Cloning, Molecular complementary DNA Developmental expression DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics genbank/x96997 gene expression Gene Expression Regulation, Developmental gene location Genes Genetics gonads Gonads - metabolism HMGB Proteins Life Sciences Male messenger RNA Molecular Sequence Data Nuclear Proteins - chemistry Nuclear Proteins - genetics Nucleotide sequence nucleotide sequences Ovis aries regulator genes Sheep Sox genes SOXB1 Transcription Factors Testis - metabolism Transcription Factors |
| title | The ovine SOX2 gene: sequence, chromosomal localization and gonadal expression |
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