Dose-related effect of aflatoxin B1 on liver drug metabolizing enzymes in rabbit

The effects of chronic administration of aflatoxin B1 (AFB1) on liver drug metabolism enzymes were measured in New Zealand rabbits divided into three groups of 5 animals, each receiving over 5 days either arabic gum or AFB1 in arabic gum at a daily oral dose of 0.05 or 0.10 mg/kg. These treatments d...

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Veröffentlicht in:	Toxicology (Amsterdam) 1996-04, Vol.108 (1), p.39-48
Hauptverfasser:	Guerre, P., Eeckhoutte, C., Larrieu, G., Burgat, V., Galtier, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aflatoxin B1 Aflatoxin B1 - administration & dosage Aflatoxin B1 - toxicity Animals Biological and medical sciences Blotting, Western Body Weight - drug effects Carcinogens - administration & dosage Carcinogens - toxicity Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Dose-Response Relationship, Drug Drug metabolizing enzymes Enzyme Inhibitors - pharmacology Glutathione S-transferase Glutathione Transferase - drug effects Glutathione Transferase - metabolism Life Sciences Liver - drug effects Liver - enzymology Male Medical sciences Microsomes, Liver - metabolism Organ Size - drug effects Plant poisons toxicology Rabbit liver Rabbits Toxicology
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