Lymphoid hypoplasia and somatic cloning
Adult somatic cloning by nuclear transfer is associated with high rate of perinatal mortality but there is still no evidence that nuclear transfer itself is responsible for these failures. We report on a longlasting defect linked to somatic cloning. Skin cells grown from an ear biopsy specimen from...
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| Veröffentlicht in: | The Lancet (British edition) 1999-05, Vol.353 (9163), p.1489-1491 |
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| container_issue | 9163 |
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| container_title | The Lancet (British edition) |
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| creator | Renard, Jean-Paul Chastant, Sylvie Chesné, Patrick Richard, Christophe Marchal, Jacques Cordonnier, Nathalie Chavatte, Pascale Vignon, Xavier |
| description | Adult somatic cloning by nuclear transfer is associated with high rate of perinatal mortality but there is still no evidence that nuclear transfer itself is responsible for these failures. We report on a longlasting defect linked to somatic cloning.
Skin cells grown from an ear biopsy specimen from a 15-day-old calf were used as a source of nuclei. The donor animal was a clone of three females obtained from embryonic cells. Clinical examination, haematological, and biochemical profiles, and echocardiography of the somatic clone were done from birth to death.
After 6 weeks of normal development, the somatic cloned calf had a sudden and rapid fall in lymphocyte count and a decrease in haemoglobin. The calf died on day 51 from severe anaemia. Necropsy revealed no abnormality except thymic atrophy and lymphoid hypoplasia.
Somatic cloning may be the cause of long-lasting deleterious effects. Our observation should be taken into account in debates on reproductive cloning in human beings. |
| doi_str_mv | 10.1016/S0140-6736(98)12173-6 |
| format | Article |
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Skin cells grown from an ear biopsy specimen from a 15-day-old calf were used as a source of nuclei. The donor animal was a clone of three females obtained from embryonic cells. Clinical examination, haematological, and biochemical profiles, and echocardiography of the somatic clone were done from birth to death.
After 6 weeks of normal development, the somatic cloned calf had a sudden and rapid fall in lymphocyte count and a decrease in haemoglobin. The calf died on day 51 from severe anaemia. Necropsy revealed no abnormality except thymic atrophy and lymphoid hypoplasia.
Somatic cloning may be the cause of long-lasting deleterious effects. Our observation should be taken into account in debates on reproductive cloning in human beings.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(98)12173-6</identifier><identifier>PMID: 10232316</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Anemia - etiology ; Anemia - pathology ; Animals ; Biological and medical sciences ; Cattle ; Cloning ; Cloning, Organism - adverse effects ; Cloning, Organism - methods ; Computer Science ; Female ; Hematologic and hematopoietic diseases ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Life Sciences ; Lymphatic system ; Lymphocytes ; Lymphopenia - etiology ; Lymphopenia - pathology ; Medical sciences ; Mutation ; Thymus Gland - pathology</subject><ispartof>The Lancet (British edition), 1999-05, Vol.353 (9163), p.1489-1491</ispartof><rights>1999 Elsevier Ltd</rights><rights>1999 INIST-CNRS</rights><rights>Copyright Lancet Ltd. May 1, 1999</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-8af797ebfc399fbd4245d7041c861a6c393f6ee7ad13bbe7814c3ba9b1969fa43</citedby><cites>FETCH-LOGICAL-c451t-8af797ebfc399fbd4245d7041c861a6c393f6ee7ad13bbe7814c3ba9b1969fa43</cites><orcidid>0000-0003-1488-4815 ; 0000-0003-0790-6377 ; 0000-0002-5632-9732 ; 0000-0002-4581-6092</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/199019905?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,45974,64362,64364,64366,72216</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1774542$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10232316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02690843$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Renard, Jean-Paul</creatorcontrib><creatorcontrib>Chastant, Sylvie</creatorcontrib><creatorcontrib>Chesné, Patrick</creatorcontrib><creatorcontrib>Richard, Christophe</creatorcontrib><creatorcontrib>Marchal, Jacques</creatorcontrib><creatorcontrib>Cordonnier, Nathalie</creatorcontrib><creatorcontrib>Chavatte, Pascale</creatorcontrib><creatorcontrib>Vignon, Xavier</creatorcontrib><title>Lymphoid hypoplasia and somatic cloning</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Adult somatic cloning by nuclear transfer is associated with high rate of perinatal mortality but there is still no evidence that nuclear transfer itself is responsible for these failures. We report on a longlasting defect linked to somatic cloning.
Skin cells grown from an ear biopsy specimen from a 15-day-old calf were used as a source of nuclei. The donor animal was a clone of three females obtained from embryonic cells. Clinical examination, haematological, and biochemical profiles, and echocardiography of the somatic clone were done from birth to death.
After 6 weeks of normal development, the somatic cloned calf had a sudden and rapid fall in lymphocyte count and a decrease in haemoglobin. The calf died on day 51 from severe anaemia. Necropsy revealed no abnormality except thymic atrophy and lymphoid hypoplasia.
Somatic cloning may be the cause of long-lasting deleterious effects. Our observation should be taken into account in debates on reproductive cloning in human beings.</description><subject>Anemia - etiology</subject><subject>Anemia - pathology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Cloning</subject><subject>Cloning, Organism - adverse effects</subject><subject>Cloning, Organism - methods</subject><subject>Computer Science</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Life Sciences</subject><subject>Lymphatic system</subject><subject>Lymphocytes</subject><subject>Lymphopenia - etiology</subject><subject>Lymphopenia - pathology</subject><subject>Medical sciences</subject><subject>Mutation</subject><subject>Thymus Gland - pathology</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0N9L5DAQB_AgHrr--BOURUTPh2qmSZPmSUT0PFjw4U7wLUzT1I20TU12F_a_t7WLHr7cQwgMn5lMvoQcAb0ECuLqDwVOEyGZ-KnyC0hBskRskQlwyZOMy-dtMvkku2QvxldKKRc02yG7QFOWMhATcj5bN93cu3I6X3e-qzE6nGJbTqNvcOHM1NS-de3LAflRYR3t4ebeJ0_3d39vH5LZ46_ftzezxPAMFkmOlVTSFpVhSlVFyVOelZJyMLkAFH2VVcJaiSWworAyB25YgaoAJVSFnO2Ti3HuHGvdBddgWGuPTj_czPRQo6lQNOdsBb09G20X_NvSxoVuXDS2rrG1fhm1UJLlQqU9PPkGX_0ytP0_NChFh5P1KBuRCT7GYKvP54HqIXL9Ebke8tQq1x-Ra9H3HW-GL4vGlv90jRn34HQDMBqsq4CtcfHLSckzPix5PTLbx7tyNuhonG2NLV2wZqFL7_6zyTsk1pqx</recordid><startdate>19990501</startdate><enddate>19990501</enddate><creator>Renard, Jean-Paul</creator><creator>Chastant, Sylvie</creator><creator>Chesné, Patrick</creator><creator>Richard, Christophe</creator><creator>Marchal, Jacques</creator><creator>Cordonnier, Nathalie</creator><creator>Chavatte, Pascale</creator><creator>Vignon, Xavier</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-1488-4815</orcidid><orcidid>https://orcid.org/0000-0003-0790-6377</orcidid><orcidid>https://orcid.org/0000-0002-5632-9732</orcidid><orcidid>https://orcid.org/0000-0002-4581-6092</orcidid></search><sort><creationdate>19990501</creationdate><title>Lymphoid hypoplasia and somatic cloning</title><author>Renard, Jean-Paul ; Chastant, Sylvie ; Chesné, Patrick ; Richard, Christophe ; Marchal, Jacques ; Cordonnier, Nathalie ; Chavatte, Pascale ; Vignon, Xavier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-8af797ebfc399fbd4245d7041c861a6c393f6ee7ad13bbe7814c3ba9b1969fa43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Anemia - etiology</topic><topic>Anemia - pathology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Cloning</topic><topic>Cloning, Organism - adverse effects</topic><topic>Cloning, Organism - methods</topic><topic>Computer Science</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Renard, Jean-Paul</au><au>Chastant, Sylvie</au><au>Chesné, Patrick</au><au>Richard, Christophe</au><au>Marchal, Jacques</au><au>Cordonnier, Nathalie</au><au>Chavatte, Pascale</au><au>Vignon, Xavier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymphoid hypoplasia and somatic cloning</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1999-05-01</date><risdate>1999</risdate><volume>353</volume><issue>9163</issue><spage>1489</spage><epage>1491</epage><pages>1489-1491</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Adult somatic cloning by nuclear transfer is associated with high rate of perinatal mortality but there is still no evidence that nuclear transfer itself is responsible for these failures. We report on a longlasting defect linked to somatic cloning.
Skin cells grown from an ear biopsy specimen from a 15-day-old calf were used as a source of nuclei. The donor animal was a clone of three females obtained from embryonic cells. Clinical examination, haematological, and biochemical profiles, and echocardiography of the somatic clone were done from birth to death.
After 6 weeks of normal development, the somatic cloned calf had a sudden and rapid fall in lymphocyte count and a decrease in haemoglobin. The calf died on day 51 from severe anaemia. Necropsy revealed no abnormality except thymic atrophy and lymphoid hypoplasia.
Somatic cloning may be the cause of long-lasting deleterious effects. Our observation should be taken into account in debates on reproductive cloning in human beings.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>10232316</pmid><doi>10.1016/S0140-6736(98)12173-6</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0003-1488-4815</orcidid><orcidid>https://orcid.org/0000-0003-0790-6377</orcidid><orcidid>https://orcid.org/0000-0002-5632-9732</orcidid><orcidid>https://orcid.org/0000-0002-4581-6092</orcidid></addata></record> |
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| ispartof | The Lancet (British edition), 1999-05, Vol.353 (9163), p.1489-1491 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EBSCOhost Business Source Complete; ProQuest Central UK/Ireland |
| subjects | Anemia - etiology Anemia - pathology Animals Biological and medical sciences Cattle Cloning Cloning, Organism - adverse effects Cloning, Organism - methods Computer Science Female Hematologic and hematopoietic diseases Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Life Sciences Lymphatic system Lymphocytes Lymphopenia - etiology Lymphopenia - pathology Medical sciences Mutation Thymus Gland - pathology |
| title | Lymphoid hypoplasia and somatic cloning |
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