Insulin-like growth factor binding protein-4 proteolytic degradation in ovine preovulatory follicles: studies of underlying mechanisms

The regulation of insulin-like growth factor binding protein (IGFBP)-4 proteolytic degradation by insulin-like growth factors (IGFs) has been largely studied in vitro, but not in vivo. The aim of this study was to investigate the involvement of IGFs, IGFBP-2, IGFBP-3, and IGFBP-3 proteolytic fragmen...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1999-09, Vol.140 (9), p.4175-4184
Hauptverfasser:	Mazerbourg, S, Zapf, J, Bar, R S, Brigstock, D R, Lalou, C, Binoux, M, Monget, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexin II Computer Science Connective tissue growth factor Connective tissues Degradation Female Follicles Follicular fluid Follicular Phase - physiology Fragments Growth factors Heparin Heparin - metabolism In vivo methods and tests Insulin Insulin-Like Growth Factor Binding Protein 3 - genetics Insulin-Like Growth Factor Binding Protein 3 - metabolism Insulin-Like Growth Factor Binding Protein 3 - pharmacology Insulin-Like Growth Factor Binding Protein 4 - metabolism Insulin-like growth factor I Insulin-Like Growth Factor I - pharmacology Insulin-like growth factor II Insulin-like growth factor-binding protein 2 Insulin-like growth factor-binding protein 3 Insulin-like growth factor-binding protein 4 Insulin-like growth factor-binding protein 5 Insulin-like growth factors Life Sciences Monoclonal antibodies Mutation - physiology Ovarian Follicle - metabolism Peptide Fragments - pharmacology Peptide Hydrolases - metabolism Peptides Peptides - chemical synthesis Peptides - pharmacology Proteinase Proteins Proteolysis Sheep Somatomedins - physiology Vitronectin
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