Activation of phosphatidylinositol 3'-kinase by insulin-like growth factor-I rescues promyeloid cells from apoptosis and permits their differentiation into granulocytes

Insulin-like growth factor-I (IGF-I) promotes cell division and prevents programmed cell death in hemopoietic progenitors. Human HL-60 promyeloid cells differentiate toward the granulocytic lineage when stimulated with retinoic acid (RA) in serum-containing medium. When deprived of serum, however, w...

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Veröffentlicht in:	The Journal of immunology (1950) 1997-07, Vol.159 (2), p.829-837
Hauptverfasser:	Liu, Q, Schacher, D, Hurth, C, Freund, GG, Dantzer, R, Kelley, KW
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Cell Differentiation - drug effects Cell Lineage - drug effects Enzyme Activation - drug effects Granulocytes - metabolism Granulocytes - pathology HL-60 Cells Humans Insulin-Like Growth Factor I - pharmacology Life Sciences Phosphatidylinositol 3-Kinases Phosphotransferases (Alcohol Group Acceptor) - metabolism Signal Transduction - drug effects
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