Small-intestinal digestion of partially resistant cornstarch in healthy subjects
The aims of this study were to measure the amount of starch from partially resistant starches (retrograded and complexed high-amylose cornstarches) escaping small-intestinal digestion in healthy humans by use of an intubation method and to compare these data with data obtained by indirect in vitro m...
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| Veröffentlicht in: | The American journal of clinical nutrition 1998-09, Vol.68 (3), p.705-710 |
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| container_title | The American journal of clinical nutrition |
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| creator | CHAMP, M. M. J MOLIS, C FLOURIE, B BORNET, F PELLIER, P COLONNA, P GALMICHE, J.-P RAMBAUD, J.-C |
| description | The aims of this study were to measure the amount of starch from partially resistant starches (retrograded and complexed high-amylose cornstarches) escaping small-intestinal digestion in healthy humans by use of an intubation method and to compare these data with data obtained by indirect in vitro methods. Experiments were carried out in vivo in 6 healthy humans by using ileal intubation and stool analysis and in vitro by using 3 different methods for analyzing resistant starch. In intubated subjects, 51 +/- 2% of the retrograded and 21 +/- 2% of the complexed starch was delivered to the ileum and was fermented almost completely in the colon. In vitro estimates of the absorption of resistant starch were much lower. We conclude that technologically modified starches may substantially increase the amount of carbohydrate available for colonic fermentation in humans, but that in vitro measurements of resistant starch are inaccurate for predicting malabsorption in healthy humans. |
| doi_str_mv | 10.1093/ajcn/68.3.705 |
| format | Article |
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M. J ; MOLIS, C ; FLOURIE, B ; BORNET, F ; PELLIER, P ; COLONNA, P ; GALMICHE, J.-P ; RAMBAUD, J.-C</creator><creatorcontrib>CHAMP, M. M. J ; MOLIS, C ; FLOURIE, B ; BORNET, F ; PELLIER, P ; COLONNA, P ; GALMICHE, J.-P ; RAMBAUD, J.-C</creatorcontrib><description>The aims of this study were to measure the amount of starch from partially resistant starches (retrograded and complexed high-amylose cornstarches) escaping small-intestinal digestion in healthy humans by use of an intubation method and to compare these data with data obtained by indirect in vitro methods. Experiments were carried out in vivo in 6 healthy humans by using ileal intubation and stool analysis and in vitro by using 3 different methods for analyzing resistant starch. In intubated subjects, 51 +/- 2% of the retrograded and 21 +/- 2% of the complexed starch was delivered to the ileum and was fermented almost completely in the colon. In vitro estimates of the absorption of resistant starch were much lower. We conclude that technologically modified starches may substantially increase the amount of carbohydrate available for colonic fermentation in humans, but that in vitro measurements of resistant starch are inaccurate for predicting malabsorption in healthy humans.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/68.3.705</identifier><identifier>PMID: 9734751</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Clinical Nutrition</publisher><subject>Adult ; Amylose - administration & dosage ; Amylose - metabolism ; Amylose - pharmacology ; Biological and medical sciences ; Carbohydrates ; Colon - metabolism ; Digestion - physiology ; Digestive system ; Feces - chemistry ; Female ; Fermentation ; Food and Nutrition ; Fundamental and applied biological sciences. Psychology ; Humans ; Ileum - drug effects ; Ileum - physiology ; Intestine. Mesentery ; Intubation, Gastrointestinal ; Life Sciences ; Male ; Small intestine ; Vertebrates: digestive system</subject><ispartof>The American journal of clinical nutrition, 1998-09, Vol.68 (3), p.705-710</ispartof><rights>1998 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Sep 1998</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-9d20b10281b2ac62244174d3d9103d6c670a6da978fa328d65e6a082ef21bb393</citedby><cites>FETCH-LOGICAL-c417t-9d20b10281b2ac62244174d3d9103d6c670a6da978fa328d65e6a082ef21bb393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2384522$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9734751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02686371$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>CHAMP, M. M. J</creatorcontrib><creatorcontrib>MOLIS, C</creatorcontrib><creatorcontrib>FLOURIE, B</creatorcontrib><creatorcontrib>BORNET, F</creatorcontrib><creatorcontrib>PELLIER, P</creatorcontrib><creatorcontrib>COLONNA, P</creatorcontrib><creatorcontrib>GALMICHE, J.-P</creatorcontrib><creatorcontrib>RAMBAUD, J.-C</creatorcontrib><title>Small-intestinal digestion of partially resistant cornstarch in healthy subjects</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>The aims of this study were to measure the amount of starch from partially resistant starches (retrograded and complexed high-amylose cornstarches) escaping small-intestinal digestion in healthy humans by use of an intubation method and to compare these data with data obtained by indirect in vitro methods. Experiments were carried out in vivo in 6 healthy humans by using ileal intubation and stool analysis and in vitro by using 3 different methods for analyzing resistant starch. In intubated subjects, 51 +/- 2% of the retrograded and 21 +/- 2% of the complexed starch was delivered to the ileum and was fermented almost completely in the colon. In vitro estimates of the absorption of resistant starch were much lower. We conclude that technologically modified starches may substantially increase the amount of carbohydrate available for colonic fermentation in humans, but that in vitro measurements of resistant starch are inaccurate for predicting malabsorption in healthy humans.</description><subject>Adult</subject><subject>Amylose - administration & dosage</subject><subject>Amylose - metabolism</subject><subject>Amylose - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carbohydrates</subject><subject>Colon - metabolism</subject><subject>Digestion - physiology</subject><subject>Digestive system</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Fermentation</subject><subject>Food and Nutrition</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Ileum - drug effects</subject><subject>Ileum - physiology</subject><subject>Intestine. Mesentery</subject><subject>Intubation, Gastrointestinal</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Small intestine</subject><subject>Vertebrates: digestive system</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0U1rGzEQBmARWlI36THHwlJCoYd1RtKuPo4hpE3B0ELSs5jVamsZWetKuwH_-8jY-NCThpmHEdJLyA2FJQXN73Bj451QS76U0F6QBdVc1ZyBfEcWAMBqTUX7gXzMeQNAWaPEJbnUkjeypQvy-3mLIdQ-Ti5PPmKoev_3UI6xGodqh2nyBeyr5LLPE8apsmOKpUp2XflYrR2Gab2v8txtnJ3yNXk_YMju0-m8In--P748PNWrXz9-PtyvattQOdW6Z9BRYIp2DK1grCntpue9psB7YYUEFD1qqQbkTPWidQJBMTcw2nVc8yvy7bh3jcHskt9i2psRvXm6X5lDD5hQgkv6Sov9erS7NP6by-vM1mfrQsDoxjkbyZVsmwYK_PIf3IxzKr-SDeNUMwCpCqqPyKYx5-SG8_UUzCESc4jECGW4KZEU__m0dO62rj_rUwZlfnuaY7YYhoTR-nxmjKumZYy_AXnfkwE</recordid><startdate>19980901</startdate><enddate>19980901</enddate><creator>CHAMP, M. M. J</creator><creator>MOLIS, C</creator><creator>FLOURIE, B</creator><creator>BORNET, F</creator><creator>PELLIER, P</creator><creator>COLONNA, P</creator><creator>GALMICHE, J.-P</creator><creator>RAMBAUD, J.-C</creator><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>19980901</creationdate><title>Small-intestinal digestion of partially resistant cornstarch in healthy subjects</title><author>CHAMP, M. M. J ; MOLIS, C ; FLOURIE, B ; BORNET, F ; PELLIER, P ; COLONNA, P ; GALMICHE, J.-P ; RAMBAUD, J.-C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-9d20b10281b2ac62244174d3d9103d6c670a6da978fa328d65e6a082ef21bb393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Amylose - administration & dosage</topic><topic>Amylose - metabolism</topic><topic>Amylose - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Carbohydrates</topic><topic>Colon - metabolism</topic><topic>Digestion - physiology</topic><topic>Digestive system</topic><topic>Feces - chemistry</topic><topic>Female</topic><topic>Fermentation</topic><topic>Food and Nutrition</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Ileum - drug effects</topic><topic>Ileum - physiology</topic><topic>Intestine. 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| ispartof | The American journal of clinical nutrition, 1998-09, Vol.68 (3), p.705-710 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Amylose - administration & dosage Amylose - metabolism Amylose - pharmacology Biological and medical sciences Carbohydrates Colon - metabolism Digestion - physiology Digestive system Feces - chemistry Female Fermentation Food and Nutrition Fundamental and applied biological sciences. Psychology Humans Ileum - drug effects Ileum - physiology Intestine. Mesentery Intubation, Gastrointestinal Life Sciences Male Small intestine Vertebrates: digestive system |
| title | Small-intestinal digestion of partially resistant cornstarch in healthy subjects |
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