Diets containing long-chain n-3 polyunsaturated fatty acids affect behaviour differently during development than ageing in mice

The effect of a standard diet providing essential fatty acids enriched in fish oil or palm oil was studied in young, mature and old mice. Two groups of pregnant and lactating OF1 mice were fed on diets with or without high levels of long-chain n-3 polyunsaturated fatty acids. Offspring were maintain...

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Veröffentlicht in:British journal of nutrition 2000-04, Vol.83 (4), p.439-447
Hauptverfasser: Carrié, Isabelle, Guesnet, Philippe, Bourre, Jean-Marie, Francès, Henriette
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creator Carrié, Isabelle
Guesnet, Philippe
Bourre, Jean-Marie
Francès, Henriette
description The effect of a standard diet providing essential fatty acids enriched in fish oil or palm oil was studied in young, mature and old mice. Two groups of pregnant and lactating OF1 mice were fed on diets with or without high levels of long-chain n-3 polyunsaturated fatty acids. Offspring were maintained on these diets after weaning. The litter size did not differ. The weight increased more quickly in fish-oil-fed mice than palm-oil-fed mice. The fish-oil diet induced a significant increase in exploratory activity in young mice which was not found in mature and old mice. The level of locomotor activity was significantly higher in young, no different in mature, and lower in old fish-oil-fed mice than in controls. Habituation, the simpler form of learning, occurred to the same extent in the two diet groups. For the place learning protocol of the Morris water maze there was no difference between the two diet groups; however, in the probe trial, the mature fish-oil-fed mice remembered the situation well compared with the control mice. In the active avoidance test, on the first day of acquisition the young fish-oil-fed mice made more avoidances than control mice, whereas in contrast, mature and old-fish-fed mice made less avoidances than control mice. These results suggest a positive effect on arousal and learning ability of a diet enriched in long chain n-3 polyunsaturated fatty acids in young mice and a detrimental effect in old mice.
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Ageing</subject><subject>Fatty Acids, Omega-3 - administration &amp; dosage</subject><subject>Female</subject><subject>Fish Oils - administration &amp; dosage</subject><subject>Food and Nutrition</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Habituation, Psychophysiologic - physiology</subject><subject>Learning</subject><subject>Learning. Memory</subject><subject>Life Sciences</subject><subject>Litter Size</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Motor Activity - physiology</subject><subject>n-3 Fatty acids</subject><subject>Plant Oils - administration &amp; dosage</subject><subject>Pregnancy</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. 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Psychophysiology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carrié, Isabelle</creatorcontrib><creatorcontrib>Guesnet, Philippe</creatorcontrib><creatorcontrib>Bourre, Jean-Marie</creatorcontrib><creatorcontrib>Francès, Henriette</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carrié, Isabelle</au><au>Guesnet, Philippe</au><au>Bourre, Jean-Marie</au><au>Francès, Henriette</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diets containing long-chain n-3 polyunsaturated fatty acids affect behaviour differently during development than ageing in mice</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2000-04-01</date><risdate>2000</risdate><volume>83</volume><issue>4</issue><spage>439</spage><epage>447</epage><pages>439-447</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>The effect of a standard diet providing essential fatty acids enriched in fish oil or palm oil was studied in young, mature and old mice. 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subjects Ageing
Aging - physiology
Animal
Animals
Arousal - physiology
Behavior, Animal - physiology
Biological and medical sciences
Body Weight
Development. Metamorphosis. Moult. Ageing
Fatty Acids, Omega-3 - administration & dosage
Female
Fish Oils - administration & dosage
Food and Nutrition
Fundamental and applied biological sciences. Psychology
Habituation, Psychophysiologic - physiology
Learning
Learning. Memory
Life Sciences
Litter Size
Mice
Mice, Inbred Strains
Motor Activity - physiology
n-3 Fatty acids
Plant Oils - administration & dosage
Pregnancy
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
title Diets containing long-chain n-3 polyunsaturated fatty acids affect behaviour differently during development than ageing in mice
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