Effect of selenium deficiency on hepatic lipid and lipoprotein metabolism in the rat
Since experimental Se deficiency results in a significant increase in plasma cholesterol concentration the present investigation was undertaken to assess further the influence of this deficiency on the expression of proteins involved in hepatic lipid metabolism. Se deficiency was induced by feeding...
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| Veröffentlicht in: | British journal of nutrition 1997-09, Vol.78 (3), p.493-500 |
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| container_title | British journal of nutrition |
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| creator | Nassir, F. Moundras, C. Bayle, D. Sérougne, C. Gueux, E. Rock, E. Rayssiguier, Y. Mazur, A. |
| description | Since experimental Se deficiency results in a significant increase in plasma cholesterol concentration the present investigation was undertaken to assess further the influence of this deficiency on the expression of proteins involved in hepatic lipid metabolism. Se deficiency was induced by feeding weanling male Wistar rats on a deficient diet for 6 weeks. Hypercholesterolaemia associated with Se deficiency was related to increased 3-hydroxy-3-methylglutaryl-coA (HMG-CoA) reductase (EC 1.1.1.34) activity in liver microsomes as compared with control animals. Hepatic lipoprotein receptor levels (LDL-receptor and HDL-binding proteins, HB1 and HB2) were not significantly affected by Se deficiency, as assessed by immunoblotting. Plasma triacylglycerol concentrations tended to decrease in Se-deficient rats in concert with their reduced post-Triton secretion. There was no significant effect of Se deficiency on the hepatic synthesis of apolipoproteins. These results point to the need for further investigations into the mechanism related to the increased activity of HMG-CoA reductase and the enhanced cholesterogenesis in the liver of Se-deficient rats likely to result from this. Selenium: Cholesterol: Triacylglycerol: HMG-CoA reductase |
| doi_str_mv | 10.1079/BJN19970166 |
| format | Article |
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Se deficiency was induced by feeding weanling male Wistar rats on a deficient diet for 6 weeks. Hypercholesterolaemia associated with Se deficiency was related to increased 3-hydroxy-3-methylglutaryl-coA (HMG-CoA) reductase (EC 1.1.1.34) activity in liver microsomes as compared with control animals. Hepatic lipoprotein receptor levels (LDL-receptor and HDL-binding proteins, HB1 and HB2) were not significantly affected by Se deficiency, as assessed by immunoblotting. Plasma triacylglycerol concentrations tended to decrease in Se-deficient rats in concert with their reduced post-Triton secretion. There was no significant effect of Se deficiency on the hepatic synthesis of apolipoproteins. These results point to the need for further investigations into the mechanism related to the increased activity of HMG-CoA reductase and the enhanced cholesterogenesis in the liver of Se-deficient rats likely to result from this. 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Se deficiency was induced by feeding weanling male Wistar rats on a deficient diet for 6 weeks. Hypercholesterolaemia associated with Se deficiency was related to increased 3-hydroxy-3-methylglutaryl-coA (HMG-CoA) reductase (EC 1.1.1.34) activity in liver microsomes as compared with control animals. Hepatic lipoprotein receptor levels (LDL-receptor and HDL-binding proteins, HB1 and HB2) were not significantly affected by Se deficiency, as assessed by immunoblotting. Plasma triacylglycerol concentrations tended to decrease in Se-deficient rats in concert with their reduced post-Triton secretion. There was no significant effect of Se deficiency on the hepatic synthesis of apolipoproteins. These results point to the need for further investigations into the mechanism related to the increased activity of HMG-CoA reductase and the enhanced cholesterogenesis in the liver of Se-deficient rats likely to result from this. Selenium: Cholesterol: Triacylglycerol: HMG-CoA reductase</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cholesterol</subject><subject>Food and Nutrition</subject><subject>General Nutrition</subject><subject>HMG-CoA reductase</subject><subject>Hydroxymethylglutaryl CoA Reductases - metabolism</subject><subject>Life Sciences</subject><subject>Lipid Metabolism</subject><subject>Lipoproteins - metabolism</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Microsomes, Liver - enzymology</subject><subject>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Selenium</subject><subject>Selenium - deficiency</subject><subject>Triacylglycerol</subject><subject>Triglycerides - blood</subject><subject>Weaning</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEuLFDEUhYMoYzu6ci1kIYJIaZLKczkO44xatAitCzchlUrsjFWVNkmJ8-9N003rwtV9nI9zLweApxi9xkioN28_rLFSAmHO74EVpoI1hHNyH6wQQqLBmLKH4FHOt3WUGKkzcKZaxKVUK7C58t7ZAqOH2Y1uDssEB-eDDW62dzDOcOt2pgQLx7ALAzTzsO_iLsXiwgwnV0wfx5AnWKeydTCZ8hg88GbM7smxnoMv7642lzdN9-n6_eVF11jGWGlsL3riCe9Za3pMjffGDohJhZnlmCDiJRMec9rSvm0JHoRUig2USzYwIWh7Dl4efLdm1LsUJpPudDRB31x0er9DhEtKOPuFK_viwNbPfy4uFz2FbN04mtnFJWuhiOKUkQq-OoA2xZyT8ydnjPQ-b_1P3pV-drRd-skNJ_YYcNWfH3WTrRl9MrMN-YQRiepZWbHmgIVc3O-TbNIPzUUrmObXn3WnuvXHb-uvevOXt2bqUxi-O30blzTXtP_75h_-hqMK</recordid><startdate>19970901</startdate><enddate>19970901</enddate><creator>Nassir, F.</creator><creator>Moundras, C.</creator><creator>Bayle, D.</creator><creator>Sérougne, C.</creator><creator>Gueux, E.</creator><creator>Rock, E.</creator><creator>Rayssiguier, Y.</creator><creator>Mazur, A.</creator><general>Cambridge University Press</general><general>Cambridge University Press (CUP)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-1067-5066</orcidid></search><sort><creationdate>19970901</creationdate><title>Effect of selenium deficiency on hepatic lipid and lipoprotein metabolism in the rat</title><author>Nassir, F. ; 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Se deficiency was induced by feeding weanling male Wistar rats on a deficient diet for 6 weeks. Hypercholesterolaemia associated with Se deficiency was related to increased 3-hydroxy-3-methylglutaryl-coA (HMG-CoA) reductase (EC 1.1.1.34) activity in liver microsomes as compared with control animals. Hepatic lipoprotein receptor levels (LDL-receptor and HDL-binding proteins, HB1 and HB2) were not significantly affected by Se deficiency, as assessed by immunoblotting. Plasma triacylglycerol concentrations tended to decrease in Se-deficient rats in concert with their reduced post-Triton secretion. There was no significant effect of Se deficiency on the hepatic synthesis of apolipoproteins. These results point to the need for further investigations into the mechanism related to the increased activity of HMG-CoA reductase and the enhanced cholesterogenesis in the liver of Se-deficient rats likely to result from this. 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| subjects | Animals Biological and medical sciences Cholesterol Food and Nutrition General Nutrition HMG-CoA reductase Hydroxymethylglutaryl CoA Reductases - metabolism Life Sciences Lipid Metabolism Lipoproteins - metabolism Liver - metabolism Male Medical sciences Metabolic diseases Microsomes, Liver - enzymology Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Rats Rats, Wistar Selenium Selenium - deficiency Triacylglycerol Triglycerides - blood Weaning |
| title | Effect of selenium deficiency on hepatic lipid and lipoprotein metabolism in the rat |
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