Pharmacodynamics and pharmacokinetics of nonsteroidal anti-inflammatory drugs in species of veterinary interest

This review summarises selected aspects of the pharmacokinetics (PK) and pharmacodynamics (PD) of nonsteroidal anti‐inflammatory drugs (NSAIDs). It is not intended to be comprehensive, in that it covers neither minor species nor several important aspects of NSAID PD. The limited objective of the rev...

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Veröffentlicht in:	Journal of veterinary pharmacology and therapeutics 2004-12, Vol.27 (6), p.479-490
Hauptverfasser:	Lees, P, Landoni, M.F, Giraudel, J, Toutain, P.L
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse effects Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Anti-Inflammatory Agents, Non-Steroidal - pharmacology binding properties bioavailability biochemical mechanisms blood proteins Cyclooxygenase Inhibitors - pharmacokinetics Cyclooxygenase Inhibitors - pharmacology drug excretion drug injection drug toxicity enantiomers enzyme inhibition half life Humans Inhibitory Concentration 50 intramuscular injection Life Sciences literature reviews Models, Animal Models, Biological nonsteroidal anti-inflammatory agents oral administration pharmacokinetics prostaglandin synthase protein binding protein isoforms Species Specificity subcutaneous injection veterinary drugs Veterinary Drugs - pharmacokinetics Veterinary Drugs - pharmacology
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