Genotype-level variation in lifetime breeding success, litter size and survival of sheep in scrapie-affected flocks
Five different sheep flocks with natural outbreaks of scrapie were examined to determine associations between individual performance (lifetime breeding success, litter size and survival) and scrapie infection or PrP genotype. Despite different breed composition and forces of infection, consistent pa...
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| Veröffentlicht in: | Journal of general virology 2005-04, Vol.86 (4), p.1229-1238 |
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| container_title | Journal of general virology |
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| creator | Chase-Topping, M.E Kruuk, L.E.B Lajous, D Touzeau, S Matthews, L Simm, G Foster, J.D Rupp, R Eychenne, F Hunter, N |
| description | Five different sheep flocks with natural outbreaks of scrapie were examined to determine associations between individual performance (lifetime breeding success, litter size and survival) and scrapie infection or PrP genotype. Despite different breed composition and forces of infection, consistent patterns were found among the flocks. Regardless of the flock, scrapie-infected sheep produced on average 34 % fewer offspring than non-scrapie-infected sheep. The effect of scrapie on lifetime breeding success appears to be a function of lifespan as opposed to fecundity. Analysis of litter size revealed no overall or genotype differences among the five sheep flocks. Survival, however, depends on the individual's scrapie status (infected or not) and its PrP genotype. Susceptible genotypes appear to perform less well in lifetime breeding success and life expectancy even if they are never affected with clinical scrapie. One possible explanation for these results is the effect of pre-clinical scrapie. Additional evidence supporting this hypothesis is discussed. |
| doi_str_mv | 10.1099/vir.0.80277-0 |
| format | Article |
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Despite different breed composition and forces of infection, consistent patterns were found among the flocks. Regardless of the flock, scrapie-infected sheep produced on average 34 % fewer offspring than non-scrapie-infected sheep. The effect of scrapie on lifetime breeding success appears to be a function of lifespan as opposed to fecundity. Analysis of litter size revealed no overall or genotype differences among the five sheep flocks. Survival, however, depends on the individual's scrapie status (infected or not) and its PrP genotype. Susceptible genotypes appear to perform less well in lifetime breeding success and life expectancy even if they are never affected with clinical scrapie. One possible explanation for these results is the effect of pre-clinical scrapie. Additional evidence supporting this hypothesis is discussed.</description><identifier>ISSN: 0022-1317</identifier><identifier>EISSN: 1465-2099</identifier><identifier>DOI: 10.1099/vir.0.80277-0</identifier><identifier>PMID: 15784917</identifier><language>eng</language><publisher>England: Soc General Microbiol</publisher><subject>Animals ; Breeding ; Computer Science ; Disease Outbreaks ; Female ; flocks ; Genetic Variation ; Genotype ; Litter Size ; Mathematics ; mortality ; prions ; Prions - genetics ; reproductive efficiency ; Scrapie - epidemiology ; Scrapie - genetics ; Scrapie - mortality ; sheep ; sheep breeds ; Sheep Diseases - epidemiology ; Sheep Diseases - genetics ; Sheep Diseases - mortality ; Sheep, Domestic - metabolism ; Sheep, Domestic - physiology ; Survival Rate</subject><ispartof>Journal of general virology, 2005-04, Vol.86 (4), p.1229-1238</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-7389cf039dbb49d262cf535cbf2ccd63c5ea3cab32dda8f180b6c5341d27b0923</citedby><cites>FETCH-LOGICAL-c452t-7389cf039dbb49d262cf535cbf2ccd63c5ea3cab32dda8f180b6c5341d27b0923</cites><orcidid>0000-0001-5255-8960 ; 0000-0003-4668-333X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3733,3734,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15784917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02683319$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Chase-Topping, M.E</creatorcontrib><creatorcontrib>Kruuk, L.E.B</creatorcontrib><creatorcontrib>Lajous, D</creatorcontrib><creatorcontrib>Touzeau, S</creatorcontrib><creatorcontrib>Matthews, L</creatorcontrib><creatorcontrib>Simm, G</creatorcontrib><creatorcontrib>Foster, J.D</creatorcontrib><creatorcontrib>Rupp, R</creatorcontrib><creatorcontrib>Eychenne, F</creatorcontrib><creatorcontrib>Hunter, N</creatorcontrib><title>Genotype-level variation in lifetime breeding success, litter size and survival of sheep in scrapie-affected flocks</title><title>Journal of general virology</title><addtitle>J Gen Virol</addtitle><description>Five different sheep flocks with natural outbreaks of scrapie were examined to determine associations between individual performance (lifetime breeding success, litter size and survival) and scrapie infection or PrP genotype. Despite different breed composition and forces of infection, consistent patterns were found among the flocks. Regardless of the flock, scrapie-infected sheep produced on average 34 % fewer offspring than non-scrapie-infected sheep. The effect of scrapie on lifetime breeding success appears to be a function of lifespan as opposed to fecundity. Analysis of litter size revealed no overall or genotype differences among the five sheep flocks. Survival, however, depends on the individual's scrapie status (infected or not) and its PrP genotype. Susceptible genotypes appear to perform less well in lifetime breeding success and life expectancy even if they are never affected with clinical scrapie. One possible explanation for these results is the effect of pre-clinical scrapie. Additional evidence supporting this hypothesis is discussed.</description><subject>Animals</subject><subject>Breeding</subject><subject>Computer Science</subject><subject>Disease Outbreaks</subject><subject>Female</subject><subject>flocks</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>Litter Size</subject><subject>Mathematics</subject><subject>mortality</subject><subject>prions</subject><subject>Prions - genetics</subject><subject>reproductive efficiency</subject><subject>Scrapie - epidemiology</subject><subject>Scrapie - genetics</subject><subject>Scrapie - mortality</subject><subject>sheep</subject><subject>sheep breeds</subject><subject>Sheep Diseases - epidemiology</subject><subject>Sheep Diseases - genetics</subject><subject>Sheep Diseases - mortality</subject><subject>Sheep, Domestic - metabolism</subject><subject>Sheep, Domestic - physiology</subject><subject>Survival Rate</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFv0zAUhy0EYl3hyBVymoZEyrOdxPZxmmBDqsQBdrYc-7k1JHGx06Dx15PQCo5c_CT_vvfJ1o-QVxQ2FJR6P4W0gY0EJkQJT8iKVk1dsjl5SlYAjJWUU3FBLnP-BkCrqhbPyQWthawUFSuS73CI4-MByw4n7IrJpGDGEIciDEUXPI6hx6JNiC4MuyIfrcWc383ROGIqcviFhRncHKQpTKYroi_yHvGw7GebzCFgabxHO6IrfBft9_yCPPOmy_jyPNfk4eOHr7f35fbz3afbm21pq5qNpeBSWQ9cubatlGMNs77mtW09s9Y13NZouDUtZ84Z6amEtrE1r6hjogXF-Jq8PXn3ptOHFHqTHnU0Qd_fbPVyB6yRnFM10Zm9OrGHFH8cMY-6D9li15kB4zHrRtRcMYD_glRIXvP5WJPyBNoUc07o_z6Bgl6q03N1GvSf6vQifn0WH9se3T_63NUMXJ-_E3b7nyGh3uHQh1nfhrjIZKMrTRlTM_rmhHoTtdmlkPXDFwaUAwWQjEv-GwburVE</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>Chase-Topping, M.E</creator><creator>Kruuk, L.E.B</creator><creator>Lajous, D</creator><creator>Touzeau, S</creator><creator>Matthews, L</creator><creator>Simm, G</creator><creator>Foster, J.D</creator><creator>Rupp, R</creator><creator>Eychenne, F</creator><creator>Hunter, N</creator><general>Soc General Microbiol</general><general>Microbiology Society</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0001-5255-8960</orcidid><orcidid>https://orcid.org/0000-0003-4668-333X</orcidid></search><sort><creationdate>20050401</creationdate><title>Genotype-level variation in lifetime breeding success, litter size and survival of sheep in scrapie-affected flocks</title><author>Chase-Topping, M.E ; 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| source | MEDLINE; Microbiology Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Breeding Computer Science Disease Outbreaks Female flocks Genetic Variation Genotype Litter Size Mathematics mortality prions Prions - genetics reproductive efficiency Scrapie - epidemiology Scrapie - genetics Scrapie - mortality sheep sheep breeds Sheep Diseases - epidemiology Sheep Diseases - genetics Sheep Diseases - mortality Sheep, Domestic - metabolism Sheep, Domestic - physiology Survival Rate |
| title | Genotype-level variation in lifetime breeding success, litter size and survival of sheep in scrapie-affected flocks |
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