PK-PD integration and PK-PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology

Much useful information relevant to elucidation of mechanism of action of nonsteroidal anti‐inflammatory drugs (NSAIDs) at the molecular level can be obtained from integrating pharmacokinetic (PK) and pharmacodynamic (PD) data, such data being obtained usually, although not necessarily, in separate...

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Veröffentlicht in:	Journal of veterinary pharmacology and therapeutics 2004-12, Vol.27 (6), p.491-502
Hauptverfasser:	Lees, P, Giraudel, J, Landoni, M.F, Toutain, P.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Anti-Inflammatory Agents, Non-Steroidal - pharmacology bioavailability biochemical mechanisms body weight carprofen cats cows Cyclooxygenase Inhibitors - pharmacokinetics Cyclooxygenase Inhibitors - pharmacology dogs dosage enzyme inhibition horses Life Sciences literature reviews mathematical models meloxicam Models, Animal Models, Biological nimesulide nonsteroidal anti-inflammatory agents pharmacokinetics Pharmacology - methods phenylbutazone prostaglandin synthase protein isoforms veterinary drugs Veterinary Drugs - pharmacokinetics Veterinary Drugs - pharmacology
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