Elaborate transcription regulation of the Bacillus subtilis ilv‐leu operon involved in the biosynthesis of branched‐chain amino acids through global regulators of CcpA, CodY and TnrA
Summary The Bacillus subtilis ilv‐leu operon involved in the biosynthesis of branched‐chain amino acids is under negative regulation mediated by TnrA and CodY, which recognize and bind to their respective cis‐elements located upstream of the ilv‐leu promoter. This operon is known to be under CcpA‐de...
Gespeichert in:
| Veröffentlicht in: | Molecular microbiology 2005-06, Vol.56 (6), p.1560-1573 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1573 |
|---|---|
| container_issue | 6 |
| container_start_page | 1560 |
| container_title | Molecular microbiology |
| container_volume | 56 |
| creator | Tojo, Shigeo Satomura, Takenori Morisaki, Kaori Deutscher, Josef Hirooka, Kazutake Fujita, Yasutaro |
| description | Summary
The Bacillus subtilis ilv‐leu operon involved in the biosynthesis of branched‐chain amino acids is under negative regulation mediated by TnrA and CodY, which recognize and bind to their respective cis‐elements located upstream of the ilv‐leu promoter. This operon is known to be under CcpA‐dependent positive regulation. We have currently identified a catabolite‐responsive element (cre) for this positive regulation (bases −96 to −82; +1 is the ilv‐leu transcription initiation base) by means of DNase I‐footprinting in vitro, and deletion and base‐substitution analyses of cre. Under nitrogen‐rich growth conditions in glucose‐minimal medium supplemented with glutamine and amino acids, CcpA and CodY exerted positive and negative regulation of ilv‐leu, respectively, but TnrA did not function. Moreover, CcpA and CodY were able to function without their counteracting regulation of each other, although the CcpA‐dependent positive regulation did not overcome the CodY‐dependent negative regulation. Furthermore, under nitrogen‐limited conditions in glucose‐minimal medium with glutamate as the sole nitrogen source, CcpA and TnrA exerted positive and negative regulation, respectively, but CodY did not function. This CcpA‐dependent positive regulation occurred without the TnrA‐dependent negative regulation. However, the TnrA‐dependent negative regulation did not occur without the CcpA‐dependent positive regulation, raising the possibility that this negative regulation might decrease the CcpA‐dependent positive regulation. The physiological role of this elaborate transcription regulation of the B. subtilis ilv‐leu operon in overall metabolic regulation in this organism is discussed. |
| doi_str_mv | 10.1111/j.1365-2958.2005.04635.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02682083v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17618954</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6505-c0645f6876fc9795acac6e107e748c3e2679a064e33f4b039014b7cc93121dbe3</originalsourceid><addsrcrecordid>eNqNkt9u0zAYxSPExMrgFZCFBBISLf4TO_YFF6UabFInboYEV5bjOI0rN87spKx3PALPw-PwJDhtt0ncgG98FP_O8Rf5ZBlAcIbSereeIcLoFAvKZxhCOoM5I3R2-yib3B88ziZQUDglHH89zZ7GuIYQEcjIk-wUUYEYg2yS_Tp3qvRB9Qb0QbVRB9v11rcgmNXg1F76GvSNAR-Uts4NEcSh7K2zEVi3_f3jpzMD8J0JibTt1rutqZLYW0rr465NKiY6xZTpCt2YKrl0oxKkNrb1IAVXMRmCH1YNWDlfKnc3gA9750J387dg4atvQLUVuG7D_Fl2UisXzfPjfpZ9-Xh-vbiYLj9_ulzMl1PNKKRTDVlOa8YLVmtRCKq00swgWJgi55oYzAqhEmMIqfMSEgFRXhZaC4IwqkpDzrI3h9xGOdkFu1FhJ72y8mK-lOM3iBnHkJMtSuzrA9sFfzOY2MuNjdo4p1rjhyhZwRnngv0TRAVDXNA8gS__Atd-CG36YYkEoxjTXCSIHyAdfIzB1PdzIijHxsi1HIshx2LIsTFy3xh5m6wvjvlDuTHVg_FYkQS8OgIqauXq8QltfOAYh5gWOHHvD9x368zuvweQV1eXoyJ_AFRL39c</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>196522549</pqid></control><display><type>article</type><title>Elaborate transcription regulation of the Bacillus subtilis ilv‐leu operon involved in the biosynthesis of branched‐chain amino acids through global regulators of CcpA, CodY and TnrA</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><source>Free Full-Text Journals in Chemistry</source><creator>Tojo, Shigeo ; Satomura, Takenori ; Morisaki, Kaori ; Deutscher, Josef ; Hirooka, Kazutake ; Fujita, Yasutaro</creator><creatorcontrib>Tojo, Shigeo ; Satomura, Takenori ; Morisaki, Kaori ; Deutscher, Josef ; Hirooka, Kazutake ; Fujita, Yasutaro</creatorcontrib><description>Summary
The Bacillus subtilis ilv‐leu operon involved in the biosynthesis of branched‐chain amino acids is under negative regulation mediated by TnrA and CodY, which recognize and bind to their respective cis‐elements located upstream of the ilv‐leu promoter. This operon is known to be under CcpA‐dependent positive regulation. We have currently identified a catabolite‐responsive element (cre) for this positive regulation (bases −96 to −82; +1 is the ilv‐leu transcription initiation base) by means of DNase I‐footprinting in vitro, and deletion and base‐substitution analyses of cre. Under nitrogen‐rich growth conditions in glucose‐minimal medium supplemented with glutamine and amino acids, CcpA and CodY exerted positive and negative regulation of ilv‐leu, respectively, but TnrA did not function. Moreover, CcpA and CodY were able to function without their counteracting regulation of each other, although the CcpA‐dependent positive regulation did not overcome the CodY‐dependent negative regulation. Furthermore, under nitrogen‐limited conditions in glucose‐minimal medium with glutamate as the sole nitrogen source, CcpA and TnrA exerted positive and negative regulation, respectively, but CodY did not function. This CcpA‐dependent positive regulation occurred without the TnrA‐dependent negative regulation. However, the TnrA‐dependent negative regulation did not occur without the CcpA‐dependent positive regulation, raising the possibility that this negative regulation might decrease the CcpA‐dependent positive regulation. The physiological role of this elaborate transcription regulation of the B. subtilis ilv‐leu operon in overall metabolic regulation in this organism is discussed.</description><identifier>ISSN: 0950-382X</identifier><identifier>EISSN: 1365-2958</identifier><identifier>DOI: 10.1111/j.1365-2958.2005.04635.x</identifier><identifier>PMID: 15916606</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Amino acids ; Amino Acids, Branched-Chain - biosynthesis ; Bacillus subtilis - genetics ; Bacillus subtilis - growth & development ; Bacillus subtilis - metabolism ; Bacteria ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Base Sequence ; Biological and medical sciences ; DNA Footprinting ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Bacterial ; Isoleucine - biosynthesis ; Leucine - biosynthesis ; Life Sciences ; Microbiology ; Microbiology and Parasitology ; Molecular Sequence Data ; Nitrogen - metabolism ; Operon ; Repressor Proteins - genetics ; Repressor Proteins - metabolism ; Response Elements - genetics ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Transcription, Genetic ; Valine - biosynthesis</subject><ispartof>Molecular microbiology, 2005-06, Vol.56 (6), p.1560-1573</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Jun 2005</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6505-c0645f6876fc9795acac6e107e748c3e2679a064e33f4b039014b7cc93121dbe3</citedby><cites>FETCH-LOGICAL-c6505-c0645f6876fc9795acac6e107e748c3e2679a064e33f4b039014b7cc93121dbe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2958.2005.04635.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2958.2005.04635.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,778,782,883,1414,1430,27907,27908,45557,45558,46392,46816</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16802572$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15916606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02682083$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Tojo, Shigeo</creatorcontrib><creatorcontrib>Satomura, Takenori</creatorcontrib><creatorcontrib>Morisaki, Kaori</creatorcontrib><creatorcontrib>Deutscher, Josef</creatorcontrib><creatorcontrib>Hirooka, Kazutake</creatorcontrib><creatorcontrib>Fujita, Yasutaro</creatorcontrib><title>Elaborate transcription regulation of the Bacillus subtilis ilv‐leu operon involved in the biosynthesis of branched‐chain amino acids through global regulators of CcpA, CodY and TnrA</title><title>Molecular microbiology</title><addtitle>Mol Microbiol</addtitle><description>Summary
The Bacillus subtilis ilv‐leu operon involved in the biosynthesis of branched‐chain amino acids is under negative regulation mediated by TnrA and CodY, which recognize and bind to their respective cis‐elements located upstream of the ilv‐leu promoter. This operon is known to be under CcpA‐dependent positive regulation. We have currently identified a catabolite‐responsive element (cre) for this positive regulation (bases −96 to −82; +1 is the ilv‐leu transcription initiation base) by means of DNase I‐footprinting in vitro, and deletion and base‐substitution analyses of cre. Under nitrogen‐rich growth conditions in glucose‐minimal medium supplemented with glutamine and amino acids, CcpA and CodY exerted positive and negative regulation of ilv‐leu, respectively, but TnrA did not function. Moreover, CcpA and CodY were able to function without their counteracting regulation of each other, although the CcpA‐dependent positive regulation did not overcome the CodY‐dependent negative regulation. Furthermore, under nitrogen‐limited conditions in glucose‐minimal medium with glutamate as the sole nitrogen source, CcpA and TnrA exerted positive and negative regulation, respectively, but CodY did not function. This CcpA‐dependent positive regulation occurred without the TnrA‐dependent negative regulation. However, the TnrA‐dependent negative regulation did not occur without the CcpA‐dependent positive regulation, raising the possibility that this negative regulation might decrease the CcpA‐dependent positive regulation. The physiological role of this elaborate transcription regulation of the B. subtilis ilv‐leu operon in overall metabolic regulation in this organism is discussed.</description><subject>Amino acids</subject><subject>Amino Acids, Branched-Chain - biosynthesis</subject><subject>Bacillus subtilis - genetics</subject><subject>Bacillus subtilis - growth & development</subject><subject>Bacillus subtilis - metabolism</subject><subject>Bacteria</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>DNA Footprinting</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Bacterial</subject><subject>Isoleucine - biosynthesis</subject><subject>Leucine - biosynthesis</subject><subject>Life Sciences</subject><subject>Microbiology</subject><subject>Microbiology and Parasitology</subject><subject>Molecular Sequence Data</subject><subject>Nitrogen - metabolism</subject><subject>Operon</subject><subject>Repressor Proteins - genetics</subject><subject>Repressor Proteins - metabolism</subject><subject>Response Elements - genetics</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription, Genetic</subject><subject>Valine - biosynthesis</subject><issn>0950-382X</issn><issn>1365-2958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkt9u0zAYxSPExMrgFZCFBBISLf4TO_YFF6UabFInboYEV5bjOI0rN87spKx3PALPw-PwJDhtt0ncgG98FP_O8Rf5ZBlAcIbSereeIcLoFAvKZxhCOoM5I3R2-yib3B88ziZQUDglHH89zZ7GuIYQEcjIk-wUUYEYg2yS_Tp3qvRB9Qb0QbVRB9v11rcgmNXg1F76GvSNAR-Uts4NEcSh7K2zEVi3_f3jpzMD8J0JibTt1rutqZLYW0rr465NKiY6xZTpCt2YKrl0oxKkNrb1IAVXMRmCH1YNWDlfKnc3gA9750J387dg4atvQLUVuG7D_Fl2UisXzfPjfpZ9-Xh-vbiYLj9_ulzMl1PNKKRTDVlOa8YLVmtRCKq00swgWJgi55oYzAqhEmMIqfMSEgFRXhZaC4IwqkpDzrI3h9xGOdkFu1FhJ72y8mK-lOM3iBnHkJMtSuzrA9sFfzOY2MuNjdo4p1rjhyhZwRnngv0TRAVDXNA8gS__Atd-CG36YYkEoxjTXCSIHyAdfIzB1PdzIijHxsi1HIshx2LIsTFy3xh5m6wvjvlDuTHVg_FYkQS8OgIqauXq8QltfOAYh5gWOHHvD9x368zuvweQV1eXoyJ_AFRL39c</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Tojo, Shigeo</creator><creator>Satomura, Takenori</creator><creator>Morisaki, Kaori</creator><creator>Deutscher, Josef</creator><creator>Hirooka, Kazutake</creator><creator>Fujita, Yasutaro</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>200506</creationdate><title>Elaborate transcription regulation of the Bacillus subtilis ilv‐leu operon involved in the biosynthesis of branched‐chain amino acids through global regulators of CcpA, CodY and TnrA</title><author>Tojo, Shigeo ; Satomura, Takenori ; Morisaki, Kaori ; Deutscher, Josef ; Hirooka, Kazutake ; Fujita, Yasutaro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6505-c0645f6876fc9795acac6e107e748c3e2679a064e33f4b039014b7cc93121dbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Amino acids</topic><topic>Amino Acids, Branched-Chain - biosynthesis</topic><topic>Bacillus subtilis - genetics</topic><topic>Bacillus subtilis - growth & development</topic><topic>Bacillus subtilis - metabolism</topic><topic>Bacteria</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacterial Proteins - metabolism</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>DNA Footprinting</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Bacterial</topic><topic>Isoleucine - biosynthesis</topic><topic>Leucine - biosynthesis</topic><topic>Life Sciences</topic><topic>Microbiology</topic><topic>Microbiology and Parasitology</topic><topic>Molecular Sequence Data</topic><topic>Nitrogen - metabolism</topic><topic>Operon</topic><topic>Repressor Proteins - genetics</topic><topic>Repressor Proteins - metabolism</topic><topic>Response Elements - genetics</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Transcription, Genetic</topic><topic>Valine - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tojo, Shigeo</creatorcontrib><creatorcontrib>Satomura, Takenori</creatorcontrib><creatorcontrib>Morisaki, Kaori</creatorcontrib><creatorcontrib>Deutscher, Josef</creatorcontrib><creatorcontrib>Hirooka, Kazutake</creatorcontrib><creatorcontrib>Fujita, Yasutaro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Molecular microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tojo, Shigeo</au><au>Satomura, Takenori</au><au>Morisaki, Kaori</au><au>Deutscher, Josef</au><au>Hirooka, Kazutake</au><au>Fujita, Yasutaro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elaborate transcription regulation of the Bacillus subtilis ilv‐leu operon involved in the biosynthesis of branched‐chain amino acids through global regulators of CcpA, CodY and TnrA</atitle><jtitle>Molecular microbiology</jtitle><addtitle>Mol Microbiol</addtitle><date>2005-06</date><risdate>2005</risdate><volume>56</volume><issue>6</issue><spage>1560</spage><epage>1573</epage><pages>1560-1573</pages><issn>0950-382X</issn><eissn>1365-2958</eissn><abstract>Summary
The Bacillus subtilis ilv‐leu operon involved in the biosynthesis of branched‐chain amino acids is under negative regulation mediated by TnrA and CodY, which recognize and bind to their respective cis‐elements located upstream of the ilv‐leu promoter. This operon is known to be under CcpA‐dependent positive regulation. We have currently identified a catabolite‐responsive element (cre) for this positive regulation (bases −96 to −82; +1 is the ilv‐leu transcription initiation base) by means of DNase I‐footprinting in vitro, and deletion and base‐substitution analyses of cre. Under nitrogen‐rich growth conditions in glucose‐minimal medium supplemented with glutamine and amino acids, CcpA and CodY exerted positive and negative regulation of ilv‐leu, respectively, but TnrA did not function. Moreover, CcpA and CodY were able to function without their counteracting regulation of each other, although the CcpA‐dependent positive regulation did not overcome the CodY‐dependent negative regulation. Furthermore, under nitrogen‐limited conditions in glucose‐minimal medium with glutamate as the sole nitrogen source, CcpA and TnrA exerted positive and negative regulation, respectively, but CodY did not function. This CcpA‐dependent positive regulation occurred without the TnrA‐dependent negative regulation. However, the TnrA‐dependent negative regulation did not occur without the CcpA‐dependent positive regulation, raising the possibility that this negative regulation might decrease the CcpA‐dependent positive regulation. The physiological role of this elaborate transcription regulation of the B. subtilis ilv‐leu operon in overall metabolic regulation in this organism is discussed.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15916606</pmid><doi>10.1111/j.1365-2958.2005.04635.x</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-382X |
| ispartof | Molecular microbiology, 2005-06, Vol.56 (6), p.1560-1573 |
| issn | 0950-382X 1365-2958 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02682083v1 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Free Full-Text Journals in Chemistry |
| subjects | Amino acids Amino Acids, Branched-Chain - biosynthesis Bacillus subtilis - genetics Bacillus subtilis - growth & development Bacillus subtilis - metabolism Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Base Sequence Biological and medical sciences DNA Footprinting DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial Isoleucine - biosynthesis Leucine - biosynthesis Life Sciences Microbiology Microbiology and Parasitology Molecular Sequence Data Nitrogen - metabolism Operon Repressor Proteins - genetics Repressor Proteins - metabolism Response Elements - genetics Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Valine - biosynthesis |
| title | Elaborate transcription regulation of the Bacillus subtilis ilv‐leu operon involved in the biosynthesis of branched‐chain amino acids through global regulators of CcpA, CodY and TnrA |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T14%3A11%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Elaborate%20transcription%20regulation%20of%20the%20Bacillus%20subtilis%20ilv%E2%80%90leu%20operon%20involved%20in%20the%20biosynthesis%20of%20branched%E2%80%90chain%20amino%20acids%20through%20global%20regulators%20of%20CcpA,%20CodY%20and%20TnrA&rft.jtitle=Molecular%20microbiology&rft.au=Tojo,%20Shigeo&rft.date=2005-06&rft.volume=56&rft.issue=6&rft.spage=1560&rft.epage=1573&rft.pages=1560-1573&rft.issn=0950-382X&rft.eissn=1365-2958&rft_id=info:doi/10.1111/j.1365-2958.2005.04635.x&rft_dat=%3Cproquest_hal_p%3E17618954%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=196522549&rft_id=info:pmid/15916606&rfr_iscdi=true |