Pharmacokinetics of ivermectin in the yak ( Bos grunniens)
The yak ( Bos grunniens) belongs to the cattle family Bovidae and lives in the mountains of China and adjacent areas. Due to the physiological adaptations of yak to its environment and the lack of data, the ivermectin pharmacokinetic was studied following a single subcutaneous dose at the recommende...
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| Veröffentlicht in: | Veterinary parasitology 2003-11, Vol.117 (1), p.153-157 |
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| creator | Dupuy, J. Yin, H. Luo, J.X. Yang, D.Y. Guan, G.Q. Ma, M.L. Sutra, J.F. Lespine, A. Boulard, C. Alvinerie, M. |
| description | The yak (
Bos grunniens) belongs to the cattle family Bovidae and lives in the mountains of China and adjacent areas. Due to the physiological adaptations of yak to its environment and the lack of data, the ivermectin pharmacokinetic was studied following a single subcutaneous dose at the recommended dose for cattle (0.2
mg
kg
−1). The observed peak plasma concentration (
C
max) was 48.93
ng
ml
−1 and the time to reach
C
max (
T
max) was 0.73 day. These results show a faster rate of absorption than in cattle. The values for the absorption half-life (
t
1/2a), the distribution half-life (
t
1/2
α
) and the terminal half-life (
t
1/2
β
) were 0.31, 0.74 and 4.82 days, respectively. The calculated area under the concentration–time curve (AUC) was 146.2
ng
day
ml
−1 and the mean residence time (MRT) was 3.57 days. The availability of ivermectin appears low in yaks in comparison to cattle but equivalent to that reported in horses and is likely to be due to physiological characteristics of this species. |
| doi_str_mv | 10.1016/j.vetpar.2003.07.025 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02681891v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0304401703003194</els_id><sourcerecordid>71344093</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-ba4cdc37e834dc3a5c248f4f4bb074766c659e7b076454311b38ff48b8b4cbb83</originalsourceid><addsrcrecordid>eNp9kFFr2zAQx8XoWNNu32Csfhrtg72TdbLkPQyy0q6DwAZbn4WkyI3S2EolJ9BvXwWH9W1wcJz43f_Ej5CPFCoKtPmyrvZu3OpY1QCsAlFBzd-QGZWClTXncEJmwABLBCpOyVlKawBAaMQ7ckqRt6KW7Yx8_b3Ssdc2PPrBjd6mInSF37vYOzv6ocg1rlzxrB-Ly-J7SMVD3A2Dd0O6ek_ednqT3IdjPyf3tzd_r-_Kxa8fP6_ni9IilWNpNNqlZcJJhrlrbmuUHXZoDAgUTWMb3jqRhwY5MkoNk12H0kiD1hjJzsnVlLvSG7WNvtfxWQXt1d18oQ5vUDeSypbuaWY_T-w2hqedS6PqfbJus9GDC7ukBGWI0LIM4gTaGFKKrvuXTEEd_Kq1mvyqg18FIp_hee3TMX9nerd8XToKzcDFBHQ6KP0QfVL3f2qgDPJVDuJAfJsIl53tvYsq2ezTuqWP2blaBv__P7wAJniVFQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71344093</pqid></control><display><type>article</type><title>Pharmacokinetics of ivermectin in the yak ( Bos grunniens)</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Dupuy, J. ; Yin, H. ; Luo, J.X. ; Yang, D.Y. ; Guan, G.Q. ; Ma, M.L. ; Sutra, J.F. ; Lespine, A. ; Boulard, C. ; Alvinerie, M.</creator><creatorcontrib>Dupuy, J. ; Yin, H. ; Luo, J.X. ; Yang, D.Y. ; Guan, G.Q. ; Ma, M.L. ; Sutra, J.F. ; Lespine, A. ; Boulard, C. ; Alvinerie, M.</creatorcontrib><description>The yak (
Bos grunniens) belongs to the cattle family Bovidae and lives in the mountains of China and adjacent areas. Due to the physiological adaptations of yak to its environment and the lack of data, the ivermectin pharmacokinetic was studied following a single subcutaneous dose at the recommended dose for cattle (0.2
mg
kg
−1). The observed peak plasma concentration (
C
max) was 48.93
ng
ml
−1 and the time to reach
C
max (
T
max) was 0.73 day. These results show a faster rate of absorption than in cattle. The values for the absorption half-life (
t
1/2a), the distribution half-life (
t
1/2
α
) and the terminal half-life (
t
1/2
β
) were 0.31, 0.74 and 4.82 days, respectively. The calculated area under the concentration–time curve (AUC) was 146.2
ng
day
ml
−1 and the mean residence time (MRT) was 3.57 days. The availability of ivermectin appears low in yaks in comparison to cattle but equivalent to that reported in horses and is likely to be due to physiological characteristics of this species.</description><identifier>ISSN: 0304-4017</identifier><identifier>EISSN: 1873-2550</identifier><identifier>DOI: 10.1016/j.vetpar.2003.07.025</identifier><identifier>PMID: 14597289</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Absorption ; Animal biology ; Animals ; Anthelmintics - blood ; Anthelmintics - pharmacokinetics ; Area Under Curve ; blood plasma ; Cattle - metabolism ; Cattle Diseases - drug therapy ; Cattle Diseases - parasitology ; drug therapy ; Female ; Injections, Subcutaneous - veterinary ; Ivermectin ; Ivermectin - blood ; Ivermectin - pharmacokinetics ; Life Sciences ; Pharmacokinetics ; subcutaneous injection ; veterinary drugs ; Veterinary medicine and animal Health ; Yak ; yaks</subject><ispartof>Veterinary parasitology, 2003-11, Vol.117 (1), p.153-157</ispartof><rights>2003 Elsevier B.V.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-ba4cdc37e834dc3a5c248f4f4bb074766c659e7b076454311b38ff48b8b4cbb83</citedby><cites>FETCH-LOGICAL-c418t-ba4cdc37e834dc3a5c248f4f4bb074766c659e7b076454311b38ff48b8b4cbb83</cites><orcidid>0000-0001-8153-8555</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304401703003194$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14597289$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02681891$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Dupuy, J.</creatorcontrib><creatorcontrib>Yin, H.</creatorcontrib><creatorcontrib>Luo, J.X.</creatorcontrib><creatorcontrib>Yang, D.Y.</creatorcontrib><creatorcontrib>Guan, G.Q.</creatorcontrib><creatorcontrib>Ma, M.L.</creatorcontrib><creatorcontrib>Sutra, J.F.</creatorcontrib><creatorcontrib>Lespine, A.</creatorcontrib><creatorcontrib>Boulard, C.</creatorcontrib><creatorcontrib>Alvinerie, M.</creatorcontrib><title>Pharmacokinetics of ivermectin in the yak ( Bos grunniens)</title><title>Veterinary parasitology</title><addtitle>Vet Parasitol</addtitle><description>The yak (
Bos grunniens) belongs to the cattle family Bovidae and lives in the mountains of China and adjacent areas. Due to the physiological adaptations of yak to its environment and the lack of data, the ivermectin pharmacokinetic was studied following a single subcutaneous dose at the recommended dose for cattle (0.2
mg
kg
−1). The observed peak plasma concentration (
C
max) was 48.93
ng
ml
−1 and the time to reach
C
max (
T
max) was 0.73 day. These results show a faster rate of absorption than in cattle. The values for the absorption half-life (
t
1/2a), the distribution half-life (
t
1/2
α
) and the terminal half-life (
t
1/2
β
) were 0.31, 0.74 and 4.82 days, respectively. The calculated area under the concentration–time curve (AUC) was 146.2
ng
day
ml
−1 and the mean residence time (MRT) was 3.57 days. The availability of ivermectin appears low in yaks in comparison to cattle but equivalent to that reported in horses and is likely to be due to physiological characteristics of this species.</description><subject>Absorption</subject><subject>Animal biology</subject><subject>Animals</subject><subject>Anthelmintics - blood</subject><subject>Anthelmintics - pharmacokinetics</subject><subject>Area Under Curve</subject><subject>blood plasma</subject><subject>Cattle - metabolism</subject><subject>Cattle Diseases - drug therapy</subject><subject>Cattle Diseases - parasitology</subject><subject>drug therapy</subject><subject>Female</subject><subject>Injections, Subcutaneous - veterinary</subject><subject>Ivermectin</subject><subject>Ivermectin - blood</subject><subject>Ivermectin - pharmacokinetics</subject><subject>Life Sciences</subject><subject>Pharmacokinetics</subject><subject>subcutaneous injection</subject><subject>veterinary drugs</subject><subject>Veterinary medicine and animal Health</subject><subject>Yak</subject><subject>yaks</subject><issn>0304-4017</issn><issn>1873-2550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFFr2zAQx8XoWNNu32Csfhrtg72TdbLkPQyy0q6DwAZbn4WkyI3S2EolJ9BvXwWH9W1wcJz43f_Ej5CPFCoKtPmyrvZu3OpY1QCsAlFBzd-QGZWClTXncEJmwABLBCpOyVlKawBAaMQ7ckqRt6KW7Yx8_b3Ssdc2PPrBjd6mInSF37vYOzv6ocg1rlzxrB-Ly-J7SMVD3A2Dd0O6ek_ednqT3IdjPyf3tzd_r-_Kxa8fP6_ni9IilWNpNNqlZcJJhrlrbmuUHXZoDAgUTWMb3jqRhwY5MkoNk12H0kiD1hjJzsnVlLvSG7WNvtfxWQXt1d18oQ5vUDeSypbuaWY_T-w2hqedS6PqfbJus9GDC7ukBGWI0LIM4gTaGFKKrvuXTEEd_Kq1mvyqg18FIp_hee3TMX9nerd8XToKzcDFBHQ6KP0QfVL3f2qgDPJVDuJAfJsIl53tvYsq2ezTuqWP2blaBv__P7wAJniVFQ</recordid><startdate>20031103</startdate><enddate>20031103</enddate><creator>Dupuy, J.</creator><creator>Yin, H.</creator><creator>Luo, J.X.</creator><creator>Yang, D.Y.</creator><creator>Guan, G.Q.</creator><creator>Ma, M.L.</creator><creator>Sutra, J.F.</creator><creator>Lespine, A.</creator><creator>Boulard, C.</creator><creator>Alvinerie, M.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-8153-8555</orcidid></search><sort><creationdate>20031103</creationdate><title>Pharmacokinetics of ivermectin in the yak ( Bos grunniens)</title><author>Dupuy, J. ; Yin, H. ; Luo, J.X. ; Yang, D.Y. ; Guan, G.Q. ; Ma, M.L. ; Sutra, J.F. ; Lespine, A. ; Boulard, C. ; Alvinerie, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-ba4cdc37e834dc3a5c248f4f4bb074766c659e7b076454311b38ff48b8b4cbb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Absorption</topic><topic>Animal biology</topic><topic>Animals</topic><topic>Anthelmintics - blood</topic><topic>Anthelmintics - pharmacokinetics</topic><topic>Area Under Curve</topic><topic>blood plasma</topic><topic>Cattle - metabolism</topic><topic>Cattle Diseases - drug therapy</topic><topic>Cattle Diseases - parasitology</topic><topic>drug therapy</topic><topic>Female</topic><topic>Injections, Subcutaneous - veterinary</topic><topic>Ivermectin</topic><topic>Ivermectin - blood</topic><topic>Ivermectin - pharmacokinetics</topic><topic>Life Sciences</topic><topic>Pharmacokinetics</topic><topic>subcutaneous injection</topic><topic>veterinary drugs</topic><topic>Veterinary medicine and animal Health</topic><topic>Yak</topic><topic>yaks</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dupuy, J.</creatorcontrib><creatorcontrib>Yin, H.</creatorcontrib><creatorcontrib>Luo, J.X.</creatorcontrib><creatorcontrib>Yang, D.Y.</creatorcontrib><creatorcontrib>Guan, G.Q.</creatorcontrib><creatorcontrib>Ma, M.L.</creatorcontrib><creatorcontrib>Sutra, J.F.</creatorcontrib><creatorcontrib>Lespine, A.</creatorcontrib><creatorcontrib>Boulard, C.</creatorcontrib><creatorcontrib>Alvinerie, M.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Veterinary parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dupuy, J.</au><au>Yin, H.</au><au>Luo, J.X.</au><au>Yang, D.Y.</au><au>Guan, G.Q.</au><au>Ma, M.L.</au><au>Sutra, J.F.</au><au>Lespine, A.</au><au>Boulard, C.</au><au>Alvinerie, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of ivermectin in the yak ( Bos grunniens)</atitle><jtitle>Veterinary parasitology</jtitle><addtitle>Vet Parasitol</addtitle><date>2003-11-03</date><risdate>2003</risdate><volume>117</volume><issue>1</issue><spage>153</spage><epage>157</epage><pages>153-157</pages><issn>0304-4017</issn><eissn>1873-2550</eissn><abstract>The yak (
Bos grunniens) belongs to the cattle family Bovidae and lives in the mountains of China and adjacent areas. Due to the physiological adaptations of yak to its environment and the lack of data, the ivermectin pharmacokinetic was studied following a single subcutaneous dose at the recommended dose for cattle (0.2
mg
kg
−1). The observed peak plasma concentration (
C
max) was 48.93
ng
ml
−1 and the time to reach
C
max (
T
max) was 0.73 day. These results show a faster rate of absorption than in cattle. The values for the absorption half-life (
t
1/2a), the distribution half-life (
t
1/2
α
) and the terminal half-life (
t
1/2
β
) were 0.31, 0.74 and 4.82 days, respectively. The calculated area under the concentration–time curve (AUC) was 146.2
ng
day
ml
−1 and the mean residence time (MRT) was 3.57 days. The availability of ivermectin appears low in yaks in comparison to cattle but equivalent to that reported in horses and is likely to be due to physiological characteristics of this species.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>14597289</pmid><doi>10.1016/j.vetpar.2003.07.025</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-8153-8555</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-4017 |
| ispartof | Veterinary parasitology, 2003-11, Vol.117 (1), p.153-157 |
| issn | 0304-4017 1873-2550 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02681891v1 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Absorption Animal biology Animals Anthelmintics - blood Anthelmintics - pharmacokinetics Area Under Curve blood plasma Cattle - metabolism Cattle Diseases - drug therapy Cattle Diseases - parasitology drug therapy Female Injections, Subcutaneous - veterinary Ivermectin Ivermectin - blood Ivermectin - pharmacokinetics Life Sciences Pharmacokinetics subcutaneous injection veterinary drugs Veterinary medicine and animal Health Yak yaks |
| title | Pharmacokinetics of ivermectin in the yak ( Bos grunniens) |
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