Inhibition of HIV-1 Replication by Cell-penetrating Peptides Binding Rev

New therapeutic agents able to block HIV-1 replication are eagerly sought after to increase the possibilities of treatment of resistant viral strains. In this report, we describe a rational strategy to identify small peptide sequences owning the dual property of penetrating within lymphocytes and of...

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Veröffentlicht in:	The Journal of biological chemistry 2004-03, Vol.279 (10), p.9208-9214
Hauptverfasser:	Roisin, Armelle, Robin, Jean-Philippe, Dereuddre-Bosquet, Nathalie, Vitte, Anne-Laure, Dormont, Dominique, Clayette, Pascal, Jalinot, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - pharmacology Biochemistry Biochemistry, Molecular Biology Gene Products, rev - drug effects Gene Products, rev - metabolism Gene Products, tat - drug effects Gene Products, tat - genetics Gene Products, tat - metabolism HIV-1 - physiology Human immunodeficiency virus 1 Humans Life Sciences Peptide Fragments - genetics Peptide Fragments - metabolism Peptide Fragments - pharmacology Protein Binding rev Gene Products, Human Immunodeficiency Virus Rev protein SHPR protein SHPT protein SUMO-1 Protein - genetics SUMO-1 Protein - metabolism SUMO-1 Protein - pharmacology tat Gene Products, Human Immunodeficiency Virus Virus Replication - drug effects
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