Intestinal intraepithelial lymphocytes prevent pathogen‐driven inflammation and regulate the Smad/T‐bet pathway of lamina propria CD4+ T cells

Intraepithelial lymphocytes (IEL) play a key role in gut homeostasis and are critical effector cells preventing the inflammatory intestinal lesions induced in mice following oral infection with Toxoplasma gondii. In this intestinal inflammatory model, CD4+ T lymphocytes from the lamina propria (LP)...

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Veröffentlicht in:	European journal of immunology 2004-04, Vol.34 (4), p.1059-1067
Hauptverfasser:	Mennechet, Franck J. D., Kasper, Lloyd H., Rachinel, Nicolas, Minns, Laurie A., Luangsay, Souphalone, Vandewalle, Alain, Buzoni‐Gatel, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals DNA-Binding Proteins - immunology Female IEL Ileitis - immunology Ileitis - parasitology Immunoblotting Inflammation Inflammation - immunology Inflammation - parasitology Intestinal Mucosa - immunology Intestinal Mucosa - parasitology Intestine Intestines - immunology Intestines - parasitology Life Sciences Mice Parasite Regulation Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - immunology Smad Proteins T-Lymphocytes - immunology T-Lymphocytes - parasitology Toxoplasma - immunology Toxoplasmosis - immunology Trans-Activators - immunology Transforming Growth Factor beta - immunology
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