Screening of 145 Anti-PrP Monoclonal Antibodies for Their Capacity to Inhibit PrPSc Replication in Infected Cells

Prion diseases are transmissible neurodegenerative disorders affecting humans and animals for which no therapeutic or prophylactic regimens exist. During the last three years several studies have shown that anti-PrP monoclonal antibodies (mAbs) can antagonize prion propagation in vitro and in vivo,...

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Veröffentlicht in:	The Journal of biological chemistry 2005-03, Vol.280 (12), p.11247-11258
Hauptverfasser:	Féraudet, Cécile, Morel, Nathalie, Simon, Stéphanie, Volland, Hervé, Frobert, Yveline, Créminon, Christophe, Vilette, Didier, Lehmann, Sylvain, Grassi, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - therapeutic use Biochemistry Biochemistry, Molecular Biology Cell Line, Tumor Dose-Response Relationship, Drug Life Sciences Mice Prion Diseases - therapy PrPC Proteins - analysis PrPSc Proteins - antagonists & inhibitors
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