Assessment of the skin photoprotective capacities of an organo-mineral broad-spectrum sunblock on two ex vivo skin models
UV irradiation can cause cutaneous damage that may be specific according to the wavelength of UV rays. For example, damage from UVB irradiation manifests itself in the form of sunburn cells and enhancement of the expression of p53, while damage from UVA exposure results in an increase in the express...
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| Veröffentlicht in: | Photodermatology, photoimmunology & photomedicine photoimmunology & photomedicine, 2003-10, Vol.19 (5), p.242-253 |
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| container_title | Photodermatology, photoimmunology & photomedicine |
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| creator | Gélis, Christelle Girard, Stéphanie Mavon, Alain Delverdier, Maxence Paillous, Nicole Vicendo, Patricia |
| description | UV irradiation can cause cutaneous damage that may be specific according to the wavelength of UV rays. For example, damage from UVB irradiation manifests itself in the form of sunburn cells and enhancement of the expression of p53, while damage from UVA exposure results in an increase in the expression of vimentin. These reactions to UV irradiation were used in this work to evaluate the photoprotective capacities of two sunblock preparations that were applied to the surface of the skin. One sunblock preparation is a UVB absorber containing zinc oxide (ZnO) and titanium oxide (TiO2) exclusively. The other sunblock preparation is a new organo‐mineral sunblock containing Tinosorb™ M, OCM, ZnO and TiO2. Evaluation of the photoprotective capacities of both preparations on hairless rat skin and on in vitro reconstructed human epidermis revealed that they were effective in preventing UVB‐induced damage. In contrast, only the organo‐mineral sunblock was effective in the prevention of UVA‐specific damage such as dermal alterations characterized by the expression of vimentin. Furthermore, our data support the fact that hairless rat skin and in vitro reconstructed human epidermis are a reliable basis for the evaluation of the photoprotective capacities of various sunscreens against UVB and UVA damage. |
| doi_str_mv | 10.1034/j.1600-0781.2003.00045.x |
| format | Article |
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For example, damage from UVB irradiation manifests itself in the form of sunburn cells and enhancement of the expression of p53, while damage from UVA exposure results in an increase in the expression of vimentin. These reactions to UV irradiation were used in this work to evaluate the photoprotective capacities of two sunblock preparations that were applied to the surface of the skin. One sunblock preparation is a UVB absorber containing zinc oxide (ZnO) and titanium oxide (TiO2) exclusively. The other sunblock preparation is a new organo‐mineral sunblock containing Tinosorb™ M, OCM, ZnO and TiO2. Evaluation of the photoprotective capacities of both preparations on hairless rat skin and on in vitro reconstructed human epidermis revealed that they were effective in preventing UVB‐induced damage. In contrast, only the organo‐mineral sunblock was effective in the prevention of UVA‐specific damage such as dermal alterations characterized by the expression of vimentin. Furthermore, our data support the fact that hairless rat skin and in vitro reconstructed human epidermis are a reliable basis for the evaluation of the photoprotective capacities of various sunscreens against UVB and UVA damage.</description><identifier>ISSN: 0905-4383</identifier><identifier>EISSN: 1600-0781</identifier><identifier>DOI: 10.1034/j.1600-0781.2003.00045.x</identifier><identifier>PMID: 14535895</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing</publisher><subject>Animals ; Biological and medical sciences ; Blotting, Western ; Cinnamates - pharmacology ; Dermatology ; Female ; hairless rat skin ; Humans ; In Vitro Techniques ; Life Sciences ; Medical sciences ; p53 ; Phenols - pharmacology ; Rats ; reconstructed human epidermis ; Skin - drug effects ; Skin - radiation effects ; Skin involvement in other diseases. Miscellaneous. 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For example, damage from UVB irradiation manifests itself in the form of sunburn cells and enhancement of the expression of p53, while damage from UVA exposure results in an increase in the expression of vimentin. These reactions to UV irradiation were used in this work to evaluate the photoprotective capacities of two sunblock preparations that were applied to the surface of the skin. One sunblock preparation is a UVB absorber containing zinc oxide (ZnO) and titanium oxide (TiO2) exclusively. The other sunblock preparation is a new organo‐mineral sunblock containing Tinosorb™ M, OCM, ZnO and TiO2. Evaluation of the photoprotective capacities of both preparations on hairless rat skin and on in vitro reconstructed human epidermis revealed that they were effective in preventing UVB‐induced damage. In contrast, only the organo‐mineral sunblock was effective in the prevention of UVA‐specific damage such as dermal alterations characterized by the expression of vimentin. Furthermore, our data support the fact that hairless rat skin and in vitro reconstructed human epidermis are a reliable basis for the evaluation of the photoprotective capacities of various sunscreens against UVB and UVA damage.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Cinnamates - pharmacology</subject><subject>Dermatology</subject><subject>Female</subject><subject>hairless rat skin</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Life Sciences</subject><subject>Medical sciences</subject><subject>p53</subject><subject>Phenols - pharmacology</subject><subject>Rats</subject><subject>reconstructed human epidermis</subject><subject>Skin - drug effects</subject><subject>Skin - radiation effects</subject><subject>Skin involvement in other diseases. Miscellaneous. General aspects</subject><subject>Sunscreening Agents - pharmacology</subject><subject>Titanium - pharmacology</subject><subject>Triazines - pharmacology</subject><subject>Ultraviolet Rays - adverse effects</subject><subject>UVA</subject><subject>UVB</subject><subject>vimentin</subject><subject>Zinc Oxide - pharmacology</subject><issn>0905-4383</issn><issn>1600-0781</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcGO0zAURSMEYsrALyBvQGKR8hzHcbJgUY1gOhBBkQosLcd5oW6TOGOnnfbvJyFVZ8vKln3ufbZOEBAKcwos_rid0wQgBJHSeQTA5gAQ8_nxWTC7XDwPZpABD2OWsqvglffbEYqBvgyuaMwZTzM-C04L79H7Btue2Ir0GyR-Z1rSbWxvO2d71L05INGqU9r0Bv2IqZZY91e1NmxMi07VpHBWlaHvBtztG-L3bVFbvSO2Jf2DJXgkB3OwU3djS6z96-BFpWqPb87rdfDry-f1zTLMf9ze3SzyUHPGeBgVZSESUBWnItalRp6hKJIKGKg41kkVUYaqSIVOslKLqKxEKTSWTAGkTGfsOvgw9W5ULTtnGuVO0iojl4tcjmcQJSLJeHKgA_t-Yoef3-_R97IxXmNdqxbt3ktBIy6AJgOYTqB21nuH1aWZghwVya0cTcjRhBwVyX-K5HGIvj3P2BcNlk_Bs5MBeHcGlNeqrpxqtfFPHIeUZwwG7tPEPZgaT__9ALlarlbDbsiHU974Ho-XvHI7mQgmuPzz_Vbma_b1W_5zLX-zR3FnvbY</recordid><startdate>200310</startdate><enddate>200310</enddate><creator>Gélis, Christelle</creator><creator>Girard, Stéphanie</creator><creator>Mavon, Alain</creator><creator>Delverdier, Maxence</creator><creator>Paillous, Nicole</creator><creator>Vicendo, Patricia</creator><general>Blackwell Publishing</general><general>Blackwell</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-5874-1547</orcidid></search><sort><creationdate>200310</creationdate><title>Assessment of the skin photoprotective capacities of an organo-mineral broad-spectrum sunblock on two ex vivo skin models</title><author>Gélis, Christelle ; Girard, Stéphanie ; Mavon, Alain ; Delverdier, Maxence ; Paillous, Nicole ; Vicendo, Patricia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5335-2bdb760af5174cdce59e7b6f030a44c6f213eab87c69dc72df7d7ced3a0083c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Cinnamates - pharmacology</topic><topic>Dermatology</topic><topic>Female</topic><topic>hairless rat skin</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Life Sciences</topic><topic>Medical sciences</topic><topic>p53</topic><topic>Phenols - pharmacology</topic><topic>Rats</topic><topic>reconstructed human epidermis</topic><topic>Skin - drug effects</topic><topic>Skin - radiation effects</topic><topic>Skin involvement in other diseases. Miscellaneous. General aspects</topic><topic>Sunscreening Agents - pharmacology</topic><topic>Titanium - pharmacology</topic><topic>Triazines - pharmacology</topic><topic>Ultraviolet Rays - adverse effects</topic><topic>UVA</topic><topic>UVB</topic><topic>vimentin</topic><topic>Zinc Oxide - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gélis, Christelle</creatorcontrib><creatorcontrib>Girard, Stéphanie</creatorcontrib><creatorcontrib>Mavon, Alain</creatorcontrib><creatorcontrib>Delverdier, Maxence</creatorcontrib><creatorcontrib>Paillous, Nicole</creatorcontrib><creatorcontrib>Vicendo, Patricia</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Photodermatology, photoimmunology & photomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gélis, Christelle</au><au>Girard, Stéphanie</au><au>Mavon, Alain</au><au>Delverdier, Maxence</au><au>Paillous, Nicole</au><au>Vicendo, Patricia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of the skin photoprotective capacities of an organo-mineral broad-spectrum sunblock on two ex vivo skin models</atitle><jtitle>Photodermatology, photoimmunology & photomedicine</jtitle><addtitle>Photodermatol Photoimmunol Photomed</addtitle><date>2003-10</date><risdate>2003</risdate><volume>19</volume><issue>5</issue><spage>242</spage><epage>253</epage><pages>242-253</pages><issn>0905-4383</issn><eissn>1600-0781</eissn><abstract>UV irradiation can cause cutaneous damage that may be specific according to the wavelength of UV rays. For example, damage from UVB irradiation manifests itself in the form of sunburn cells and enhancement of the expression of p53, while damage from UVA exposure results in an increase in the expression of vimentin. These reactions to UV irradiation were used in this work to evaluate the photoprotective capacities of two sunblock preparations that were applied to the surface of the skin. One sunblock preparation is a UVB absorber containing zinc oxide (ZnO) and titanium oxide (TiO2) exclusively. The other sunblock preparation is a new organo‐mineral sunblock containing Tinosorb™ M, OCM, ZnO and TiO2. Evaluation of the photoprotective capacities of both preparations on hairless rat skin and on in vitro reconstructed human epidermis revealed that they were effective in preventing UVB‐induced damage. In contrast, only the organo‐mineral sunblock was effective in the prevention of UVA‐specific damage such as dermal alterations characterized by the expression of vimentin. Furthermore, our data support the fact that hairless rat skin and in vitro reconstructed human epidermis are a reliable basis for the evaluation of the photoprotective capacities of various sunscreens against UVB and UVA damage.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing</pub><pmid>14535895</pmid><doi>10.1034/j.1600-0781.2003.00045.x</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-5874-1547</orcidid></addata></record> |
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| identifier | ISSN: 0905-4383 |
| ispartof | Photodermatology, photoimmunology & photomedicine, 2003-10, Vol.19 (5), p.242-253 |
| issn | 0905-4383 1600-0781 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Animals Biological and medical sciences Blotting, Western Cinnamates - pharmacology Dermatology Female hairless rat skin Humans In Vitro Techniques Life Sciences Medical sciences p53 Phenols - pharmacology Rats reconstructed human epidermis Skin - drug effects Skin - radiation effects Skin involvement in other diseases. Miscellaneous. General aspects Sunscreening Agents - pharmacology Titanium - pharmacology Triazines - pharmacology Ultraviolet Rays - adverse effects UVA UVB vimentin Zinc Oxide - pharmacology |
| title | Assessment of the skin photoprotective capacities of an organo-mineral broad-spectrum sunblock on two ex vivo skin models |
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