Molecular mechanisms of the naringin low uptake by intestinal Caco-2 cells

Naringin, the main flavanone of grapefruit, was reported to display numerous biological effects: antioxidant, hypocholesteremic, anti‐atherogenic and favoring drug absorption. Naringin absorption mechanisms were studied in Caco‐2 cells (TC7 clone). We investigated the possible involvement of several...

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Veröffentlicht in:	Molecular nutrition & food research 2005-10, Vol.49 (10), p.957-962
Hauptverfasser:	Tourniaire, Franck, Hassan, Meryl, André, Marc, Ghiringhelli, Odette, Alquier, Christian, Amiot, Marie-Josèphe
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors ATP-Binding Cassette, Sub-Family B, Member 1 - physiology Biological and medical sciences Biological Transport - drug effects Caco-2 Cells Caco-2/TC7 cells Carrier Proteins - antagonists & inhibitors Carrier Proteins - metabolism Flavanones - metabolism Food industries Fundamental and applied biological sciences. Psychology Humans Intestinal absorption Intestinal Absorption - drug effects Intestines - metabolism Life Sciences Naringin P-glycoprotein Permeability Verapamil - pharmacology
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