Heterogeneous inducible mammary-specific expression of JAB/SOCS1 in lactating transgenic mice is associated with no obvious phenotype, even at the cellular level

The cytokine-inducible suppressor of cytokine signalling SOCS1, or JAB, has been shown to be implicated in vitro in the negative regulation of the prolactin-receptor-induced activation of JAK2 and STAT5. Disruption of this gene in vivo resulted in an accelerated mammary gland development. In the pre...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Transgenic research 2003-12, Vol.12 (6), p.693-706
Hauptverfasser:	PETRIDOU, Barbara, SOULIER, Solange, BESNARD, Nathalie, HUDRISIER, Marthe, HUE-BEAUVAIS, Catherine, COSTA DA SILVA, José, DJIANE, Jean, VILOTTE, Jean-Luc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotechnology Carrier Proteins - metabolism CHO Cells Computer Science Cricetinae Cricetulus Female Fundamental and applied biological sciences. Psychology Gene expression Genetic engineering Genetic technics Immunohistochemistry JAB protein Jak2 protein Lactation Life Sciences Mammary Glands, Animal - metabolism Methods. Procedures. Technologies Mice Mice, Transgenic Milk Proteins - metabolism Phenotype Pregnancy prolactin receptors Promoter Regions, Genetic Proteins Repressor Proteins - metabolism Rodents SOCS1 protein Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins Transgenes Transgenic animals and transgenic plants
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!