Mechanism of Ruminant Placental Lactogen Action: Molecular and in Vivo Studies

Ruminant placental lactogens (PLs) are structurally related to prolactins (PRLs) and growth hormones (GHs) and are secreted by placentae. Ruminant PLs are unusual in their capacity to bind and activate PRL and GH receptors (Rs) from other species. The present minireview summarizes several works show...

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Veröffentlicht in:	Molecular Genetics and Metabolism 2002-03, Vol.75 (3), p.189-201
Hauptverfasser:	Gertler, Arieh, Djiane, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bovine placental lactogen Female heterodimerization Humans Life Sciences Models, Molecular Mutation ovine placental lactogen Placental Lactogen - chemistry Placental Lactogen - genetics Placental Lactogen - pharmacology prolactin receptors Protein Conformation Receptors, Prolactin - drug effects Receptors, Prolactin - metabolism Receptors, Somatotropin - drug effects Receptors, Somatotropin - metabolism Signal Transduction site-directed mutagenesis species specificity
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