Proteomic Analysis Reveals Changes in the Liver Protein Pattern of Rats Exposed to Dietary Folate Deficiency

Epidemiologic and experimental studies showed that folate deficiency is associated with increased risk of degenerative diseases by enhancing abnormal one-carbon metabolism. We studied the changes in the proteome of liver, the main tissue of folate storage and metabolism, in a rat model of dietary fo...

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Veröffentlicht in:	The Journal of nutrition 2005-11, Vol.135 (11), p.2524-2529
Hauptverfasser:	Chanson, Aurélie, Sayd, Thierry, Rock, Edmond, Chambon, Christophe, Santé-Lhoutellier, Véronique, Potier de Courcy, Geneviève, Brachet, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - administration & dosage animal models Animals binding proteins Biological and medical sciences blood chemistry Blotting, Western Diet Dietary Supplements Electrophoresis, Gel, Two-Dimensional enzyme activity Feeding. Feeding behavior folic acid Folic Acid - administration & dosage Folic Acid Deficiency - metabolism Food and Nutrition Fundamental and applied biological sciences. Psychology gene expression glutathione peroxidase Glutathione Peroxidase - analysis Glutathione Peroxidase GPX1 homocysteine isoelectric point Life Sciences Liver - chemistry Liver - enzymology liver protein Male nutrient deficiencies nutrient intake nutritional status oxidative stress peroxidases peroxiredoxin protein synthesis Proteins - analysis Proteomics Rats Rats, Wistar Sensitivity and Specificity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Vertebrates: anatomy and physiology, studies on body, several organs or systems
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