Chronic administration of tianeptine balances lipopolysaccharide-induced expression of cytokines in the spleen and hypothalamus of rats

The antidepressant tianeptine has been shown to protect the hippocampus against the deleterious consequences of stress and to attenuate the behavioral and neuroendocrine effects of the cytokine inducer lipopolysaccharide (LPS). Since sickness symptoms are linked to peripheral and brain production of...

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Veröffentlicht in:	Psychoneuroendocrinology 2004-07, Vol.29 (6), p.778-790
Hauptverfasser:	Castanon, Nathalie, Médina, Chantal, Mormède, Cécile, Dantzer, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents, Tricyclic - administration & dosage Behavioral psychophysiology Biological and medical sciences Brain Drug Administration Schedule Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Hippocampus - metabolism Hypothalamus - drug effects Hypothalamus - metabolism Interleukin-1 - genetics Interleukin-1 - metabolism Interleukin-10 - genetics Interleukin-10 - metabolism Interleukin-6 - genetics Interleukin-6 - metabolism Interleukins - genetics Interleukins - metabolism Life Sciences Lipopolysaccharide Lipopolysaccharides - immunology Male Miscellaneous Neuroprotective Agents - administration & dosage Pituitary Gland - drug effects Pituitary Gland - metabolism Pro- and anti-inflammatory cytokines Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rat Rats Rats, Wistar RNA, Messenger - analysis Spleen Spleen - drug effects Spleen - metabolism Thiazepines - administration & dosage Tianeptine Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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