P-glycoprotein in helminths: function and perspectives for anthelmintic treatment and reversal of resistance

Infestation with parasitic helminths is a common problem in human populations of third world countries and is ubiquitous in livestock and other domestic animals. The cell-membrane efflux pump, P-glycoprotein (Pgp), appears to contribute to anthelmintic resistance. Pgp have been identified from both...

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Veröffentlicht in:	International journal of antimicrobial agents 2003-09, Vol.22 (3), p.332-346
Hauptverfasser:	Kerboeuf, Dominique, Blackhall, William, Kaminsky, Ronald, von Samson-Himmelstjerna, Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthelmintics - metabolism Anthelmintics - pharmacology ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biological Transport, Active Caenorhabditis elegans Caenorhabditis elegans - drug effects Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Drug Resistance Genes, Helminth Haemonchus contortus Helminth Proteins - genetics Helminth Proteins - metabolism Helminths Helminths - drug effects Helminths - genetics Helminths - metabolism Humans Lectins - pharmacology Life Sciences MDR Nematoda Nematoda - drug effects Nematoda - genetics Nematoda - metabolism P-glycoprotein Platyhelminths - drug effects Platyhelminths - genetics Platyhelminths - metabolism Resistance Reversal Trypanosoma - drug effects Trypanosoma - genetics Trypanosoma - metabolism Trypanosoma brucei Trypanosomes
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