Glucokinase activation induces potent hypoglycemia without recruiting insulin and inhibits food intake in chicken
Research highlights ► A GKA reveals a prominent role of glucokinase in chicken plasma glucose regulation. ► GKA modified GK kinetic parameters of chicken liver homogenates. ► GKA induced 40–50% decrease in plasma glucose level in fed chickens. ► GKA hypoglycemic action appeared to rely mostly on an...
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| Veröffentlicht in: | General and comparative endocrinology 2010-12, Vol.169 (3), p.276-283 |
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| container_title | General and comparative endocrinology |
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| creator | Rideau, Nicole Derouet, Michel Grimsby, Joseph Simon, Jean |
| description | Research highlights ► A GKA reveals a prominent role of glucokinase in chicken plasma glucose regulation. ► GKA modified GK kinetic parameters of chicken liver homogenates. ► GKA induced 40–50% decrease in plasma glucose level in fed chickens. ► GKA hypoglycemic action appeared to rely mostly on an effect on liver GK in chicken. ► GKA exerted a transient inhibitory effect on food intake. |
| doi_str_mv | 10.1016/j.ygcen.2010.09.002 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0016-6480 |
| ispartof | General and comparative endocrinology, 2010-12, Vol.169 (3), p.276-283 |
| issn | 0016-6480 1095-6840 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Blood Glucose - metabolism Chicken Chickens Eating - drug effects Endocrinology & Metabolism Endocrinology and metabolism Enzyme Activation Fasting Food intake Glucagon - blood Glucokinase Glucokinase - metabolism Human health and pathology Hypoglycemia - chemically induced Insulin - blood Insulin - metabolism Life Sciences Liver Male Plasma glucose level Sulfones - pharmacology Thiazoles - pharmacology |
| title | Glucokinase activation induces potent hypoglycemia without recruiting insulin and inhibits food intake in chicken |
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