Glucokinase activation induces potent hypoglycemia without recruiting insulin and inhibits food intake in chicken

Research highlights ► A GKA reveals a prominent role of glucokinase in chicken plasma glucose regulation. ► GKA modified GK kinetic parameters of chicken liver homogenates. ► GKA induced 40–50% decrease in plasma glucose level in fed chickens. ► GKA hypoglycemic action appeared to rely mostly on an...

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Veröffentlicht in:	General and comparative endocrinology 2010-12, Vol.169 (3), p.276-283
Hauptverfasser:	Rideau, Nicole, Derouet, Michel, Grimsby, Joseph, Simon, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Chicken Chickens Eating - drug effects Endocrinology & Metabolism Endocrinology and metabolism Enzyme Activation Fasting Food intake Glucagon - blood Glucokinase Glucokinase - metabolism Human health and pathology Hypoglycemia - chemically induced Insulin - blood Insulin - metabolism Life Sciences Liver Male Plasma glucose level Sulfones - pharmacology Thiazoles - pharmacology
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Beschreibung
Zusammenfassung:	Research highlights ► A GKA reveals a prominent role of glucokinase in chicken plasma glucose regulation. ► GKA modified GK kinetic parameters of chicken liver homogenates. ► GKA induced 40–50% decrease in plasma glucose level in fed chickens. ► GKA hypoglycemic action appeared to rely mostly on an effect on liver GK in chicken. ► GKA exerted a transient inhibitory effect on food intake.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2010.09.002