Differential inhibition of cyclooxygenase isoenzymes in the cat by the NSAID robenacoxib

Robenacoxib is a new nonsteroidal anti-inflammatory drug (NSAID) developed for use in companion animal medicine. The objectives of this study were: to quantify the inhibitory actions of robenacoxib on cyclooxygenase (COX) isoenzymes in feline whole blood assays; to establish blood concentration-time...

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Veröffentlicht in:	Journal of veterinary pharmacology and therapeutics 2009-02, Vol.32 (1), p.31-40
Hauptverfasser:	GIRAUDEL, J.M, TOUTAIN, P.-L, KING, J.N, LEES, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - blood Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Anti-Inflammatory Agents, Non-Steroidal - pharmacology Area Under Curve cats Cats - blood Cats - metabolism Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - administration & dosage Cyclooxygenase 2 Inhibitors - blood Cyclooxygenase 2 Inhibitors - pharmacokinetics Cyclooxygenase 2 Inhibitors - pharmacology Cyclooxygenase Inhibitors - administration & dosage Cyclooxygenase Inhibitors - blood Cyclooxygenase Inhibitors - pharmacokinetics Cyclooxygenase Inhibitors - pharmacology Dose-Response Relationship, Drug enzyme inhibition enzyme inhibitors Female in vitro studies Inhibitory Concentration 50 Injections, Intravenous - veterinary Injections, Subcutaneous - veterinary intravenous injection Isoenzymes - antagonists & inhibitors Isoenzymes - blood isozymes Life Sciences lipopolysaccharides Male nonsteroidal anti-inflammatory agents pharmacokinetics prostaglandin synthase robenacoxib subcutaneous injection temporal variation Thromboxane B2 - biosynthesis Thromboxane B2 - blood Thromboxane B2 - metabolism
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