Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors

Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific Lactobacillus strains induced the expression of μ-opioid and cannabinoid receptors in intestinal epithelial cel...

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Veröffentlicht in:	Nature Medicine 2007-01, Vol.13 (1), p.35-37
Hauptverfasser:	Desreumaux, Pierre, Rousseaux, Christel, Thuru, Xavier, Gelot, Agathe, Barnich, Nicolas, Neut, Christel, Dubuquoy, Laurent, Dubuquoy, Caroline, Merour, Emilie, Geboes, Karen, Chamaillard, Mathias, Ouwehand, Arthur, Leyer, Greg, Carcano, Didier, Colombel, Jean-Frédéric, Ardid, Denis
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Pain - physiopathology Abdominal Pain - prevention & control Administration, Oral Analgesics, Opioid - administration & dosage Analgesics, Opioid - pharmacology Animals Bacteria Biomedical and Life Sciences Biomedicine brief-communication Cancer Research Cannabinoid Receptor Antagonists Colon - drug effects Colon - microbiology Colon - physiopathology Dose-Response Relationship, Drug Gastrointestinal diseases HT29 Cells Humans Hypersensitivity Indoles - administration & dosage Indoles - pharmacology Infectious Diseases Intestines - drug effects Intestines - microbiology Intestines - physiopathology Irritable bowel syndrome Lactobacillus acidophilus Lactobacillus acidophilus - physiology Life Sciences Male Metabolic Diseases Mice Mice, Inbred BALB C Microbiology Molecular Medicine Morphine - administration & dosage Morphine - pharmacology Naloxone - administration & dosage Naloxone - pharmacology Narcotic Antagonists - administration & dosage Narcotic Antagonists - pharmacology Neurosciences Pain Probiotics - administration & dosage Probiotics - pharmacology Rats Rats, Sprague-Dawley Receptor, Cannabinoid, CB2 - antagonists & inhibitors Receptor, Cannabinoid, CB2 - biosynthesis Receptor, Cannabinoid, CB2 - physiology Receptors, Cannabinoid - biosynthesis Receptors, Cannabinoid - physiology Receptors, Opioid - biosynthesis Receptors, Opioid - physiology Receptors, Opioid, mu - antagonists & inhibitors Receptors, Opioid, mu - biosynthesis Receptors, Opioid, mu - physiology Rectum - drug effects Rectum - microbiology Rectum - physiopathology
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